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CAMBRIDGE, MASS. & OSAKA, JAPAN--( / ) June 01, 2020 -- Takeda Pharmaceutical Company Limited (TSE:4502/NYSE:TAK) today announced the results of the Phase 2 Pevonedistat-2001 trial will be presented during oral sessions at the virtual 56th American Society of Clinical Oncology (ASCO) Annual Meeting and the virtual 25th European Hematology Association (EHA) Annual Meeting. The study evaluated pevonedistat plus azacitidine versus azacitidine alone in patients with rare leukemias, including higher-risk myelodysplastic syndromes (HR-MDS). These results show that the combination of pevonedistat and azacitidine is a highly active, promising therapeutic approach and suggest benefit in the HR-MDS subgroup across multiple clinically meaningful endpoints, including overall survival (OS), event-free survival (EFS), complete remission (CR) and transfusion independence, with a safety profile similar to azacitidine alone.

The Pevonedistat-2001 trial was designed as a proof-of-concept study in patients with HR-MDS, higher-risk chronic myelomonocytic leukemia (HR-CMML) and low-blast acute myeloid leukemia (LB-AML). Though it did not achieve pre-defined statistical significance for the primary endpoint of OS, treatment with the pevonedistat combination demonstrated a numerically longer OS compared with azacitidine alone and a trend towards benefit in EFS, defined as death or transformation to AML.

“We are very optimistic about pevonedistat based on these Phase 2 results, particularly in the higher-risk MDS subgroup, which showed that the combination of pevonedistat and azacitidine provided benefit to patients at the level of several key endpoints, without introducing additional safety concerns. Not only did the combination demonstrate longer survival, but patients in the higher-risk MDS subgroup also achieved higher response rates and increased transfusion independence,” said Christopher Arendt, Head, Oncology Therapeutic Area Unit, Takeda. “We are looking forward to building on this dataset with our Phase 3 PANTHER trial, which completed enrollment last fall, and will support registration for pevonedistat globally.”

There have been no treatment advancements for HR-MDS in more than a decade and current treatment options provide limited benefit. Pevonedistat could be the first new treatment option for these patients.

“It’s exciting to see such encouraging results in the Pevonedistat-2001 trial, particularly in higher-risk MDS, an aggressive type of MDS associated with poor prognosis, diminished quality of life, and higher chance of transformation to AML,” said Lionel Ades, MD, PhD, Hopital Saint-Louis, and a primary investigator of the Pevonedistat-2001 study. “Adding pevonedistat to the current standard of care in higher-risk MDS doubled complete remission rates, increased the duration of response and improved long-term outcomes with a safety profile similar to azacitidine alone, which may address a significant need for people living with this disease.”

Primary Results from the Phase 2 Pevonedistat-2001 Trial of Pevonedistat Plus Azacitidine in Patients with Higher-Risk Myelodysplastic Syndromes (HR-MDS), Higher-Risk Chronic Myelomonocytic Leukemia (HR-CMML) and Low-Blast Acute Myeloid Leukemia (LB-AML).

Key findings, to be presented by Dr. Lionel Ades, include:

· Intent to treat population (n=120):

- Median OS was 21.8 months (mos.) in the pevonedistat combination arm, vs. 19.0 mos. with azacitidine alone (HR 0.802; p = 0.334).

- EFS trended longer in the pevonedistat combination arm vs. azacitidine alone with a median of 21.0 mos. vs. 16.6 mos.

· HR-MDS Subgroup (n=67):

- Median OS in the pevonedistat combination arm alone was 23.9 mos. vs. 19.1 mos. with azacitidine alone.

- Median EFS in the pevonedistat combination arm was 20.2 mos. vs. 14.8 mos. with azacitidine alone.

- Overall response rate (ORR) in the pevonedistat combination arm was 79.3% vs. 56.7% with azacitidine alone.

- CR rate in the pevonedistat combination arm was 51.7% vs. 26.7% with azacitidine alone.

- Median duration of response (DoR) in the pevonedistat combination arm was 34.6 months vs. 13.1 mos. with azacitidine alone.

- Of the patients who were red blood cell (RBC) transfusion dependent at baseline, 69.2% receiving pevonedistat plus azacitidine vs. 50.0% receiving azacitidine alone became transfusion independent.

· LB-AML (n=36) & HR-CMML (n=17) Subgroups:

- Median OS in LB-AML was 23.6 mos. in the pevonedistat combination arm vs. 16.0 mos. with azacitidine alone.

- Median OS and EFS in HR-CMML favored the azacitidine alone arm, which may be due to low sample size and/or greater patient heterogeneity.

· Safety data includes:

- The safety profile of pevonedistat combined with azacitidine was similar to azacitidine alone, and did not lead to increased myelosuppression.

- The most common grade ≥3 AEs across both arms were neutropenia (33% vs. 27%), febrile neutropenia (26% vs. 29%), decreased neutrophil count (21% vs. 10%), anemia (19% vs. 27%), thrombocytopenia (19% vs. 23%), and pneumonia (12% vs. 10%).

- On-study deaths occurred in 9% of patients in the pevonedistat combination arm versus 16% with azacitidine alone.

About the Pevonedistat-2001 Trial

Pevonedistat-2001 (NCT02610777) is a global, randomized, controlled, open-label, multi-center, Phase 2 clinical trial designed to evaluate the safety and efficacy of pevonedistat in combination with azacitidine versus single-agent azacitidine in patients with higher-risk MDS or CMML, or low-blast AML, who were ineligible for stem cell transplant and have not received prior therapies. Approximately 120 participants were enrolled worldwide. The primary endpoint of the trial is OS.

About Pevonedistat

Pevonedistat is a first in class NEDD8-activating enzyme (NAE) inhibitor, which blocks modifications of select proteins. Pevonedistat treatment disrupts cell cycle progression and cell survival, leading to cell death in cancers including leukemias. Pevonedistat in combination with azacitidine demonstrated antitumor activity in preclinical studies and was well tolerated, with promising clinical activity, in a Phase 1 study of patients with AML. Pevonedistat is currently being evaluated in Phase 3 studies as a first-line treatment for patients with HR-MDS, HR-CMML, and AML, who are ineligible (unfit) for transplant or intensive induction chemotherapy and is also being explored in a Phase 2 study in unfit AML in a triple combination with azacitidine and venetoclax.

About MDS, CMML and AML

MDS, CMML and AML are rare forms of bone marrow-related cancer caused by irregular blood cell production within the bone marrow. These cancers most commonly affect older patients, with the median age of diagnosis ranging from 60 to 74 years. As a result of this irregular production, a person with MDS, CMML or AML does not have enough normal red blood cells, white blood cells and/or platelets in circulation. Symptoms for MDS, CMML and AML are often vague and related to low blood counts, and may include fatigue, shortness of breath, easy bruising or bleeding, loss of appetite, weakness, pale skin, fever and frequent or severe infections.

There are several classifications of MDS - very low risk to very high risk - determined by blood counts, blast counts, mutations and cytogenetics. Higher-risk disease is defined as intermediate, high or very high risk on the International Prognostic Scoring System - Revised (IPSS-R), and these patients have a poorer prognosis. Approximately 40% of patients with HR-MDS transform to AML, an aggressive form of acute leukemia in adults, with poor outcomes.

Takeda’s Commitment to Oncology

Our core R&D mission is to deliver novel medicines to patients with cancer worldwide through our commitment to science, breakthrough innovation and passion for improving the lives of patients. Whether it’s with our hematology therapies, our robust pipeline, or solid tumor medicines, we aim to stay both innovative and competitive to bring patients the treatments they need. For more information, visit

About Takeda Pharmaceutical Company Limited

Takeda Pharmaceutical Company Limited (TSE:4502/NYSE:TAK) is a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, committed to bringing Better Health and a Brighter Future to patients by translating science into highly-innovative medicines. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Rare Diseases, Neuroscience, and Gastroenterology (GI). We also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. We are focusing on developing highly innovative medicines that contribute to making a difference in people's lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline. Our employees are committed to improving quality of life for patients and to working with our partners in health care in approximately 80 countries.

For more information, visit

Important Notice

For the purposes of this notice, “press release” means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited (“Takeda”) regarding this release. This press release (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this press release. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This press release is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws.

The companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, “Takeda” is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.

Forward-Looking Statements

This press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda’s future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”, “aims”, “intends”, “ensures”, “will”, “may”, “should”, “would”, “could” “anticipates”, “estimates”, “projects” or similar expressions or the negative thereof. Forward-looking statements in this document are based on Takeda’s estimates and assumptions only as of the date hereof. Such forward-looking statements do not represent any guarantee by Takeda or its management of future performance and involve known and unknown risks, uncertainties and other factors, including but not limited to: the economic circumstances surrounding Takeda’s global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations; the success of or failure of product development programs; decisions of regulatory authorities and the timing thereof; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the timing and impact of post-merger integration efforts with acquired companies; and the ability to divest assets that are not core to Takeda’s operations and the timing of any such divestment(s), any of which may cause Takeda’s actual results, performance, achievements or financial position to be materially different from any future results, performance, achievements or financial position expressed or implied by such forward-looking statements. For more information on these and other factors which may affect Takeda’s results, performance, achievements, or financial position, see “Item 3. Key Information?D. Risk Factors” in Takeda’s most recent Annual Report on Form 20-F and Takeda’s other reports filed with the U.S. Securities and Exchange Commission, available on Takeda’s website at: or at Future results, performance, achievements or financial position of Takeda could differ materially from those expressed in or implied by the forward-looking statements. Persons receiving this press release should not rely unduly on any forward-looking statements. Takeda undertakes no obligation to update any of the forward-looking statements contained in this press release or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results of Takeda in this press release may not be indicative of, and are not an estimate, forecast or projection of Takeda’s future results.

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어둔동성인용품 섹시한여자뒤태 브레이브걸스예진움짤 헌팅 이민정이상우 슬로바키아지도 봉투붙이기부업 휴지킹같은사이트 놀이터사이트 비뇨기과추천 미팅2030 항문질환 철수네 누나의가슴 외국섹스동영상 스포츠기록분석연구원 글래머크리스탈스타일러웨이브 은교넷서버 종로출장마사지 3d사진 onlinegame 미료성형전 하월곡동룸싸롱 upskirt 공서영몸매 성인전문사이트 질싸다닷컴우회 섹스머신 니가제일좋아뮤비 장쯔이노출영화 이현승 실옥동나이트 회색 로렉스데이저스트 날씨예보 유명카지노사이트 모바일증권계좌개설 PaksiSE 게임만화책 울산요실금 부산노래방 제니퍼의육체 얼굴주름없애기 윤지수나이 토리버치카드지갑 민지초혼 대방동성인용품 플래시포커 상지석동건마 신선동토킹bar VALENTI 몸캠녀 인터넷증권계좌개설 섹시화보2 세인트패트릭스 한복티팬티 농구토토배당율 초보주식공부 프리미어리그 패딩 에프엑스 대전sbs스포츠 동방신기레전드팬픽 스타드브레스트29 적극성 밤토끼 바이넥스 본동떡집 [1이닝무득점]보스턴 교촌동유흥거리 신하동키스방 강민경헤어라인 팬티노출사고 직업추천 워크넷 제주나이트 티아라노출사진 엑소라니아 씨스타보라엉덩이 트로트다운 윤승아비키니 스포츠토토베트맨 유리허벅지 여의동유흥문화 아현동레깅스룸 신간도서 아이돌비리 케이팝딥페이크주소찾기 제주경마장가는길 내집마련방법 복권당첨되는방법 AVSEE 브래지어와이어 오메가 섹스테크닉 여자친구생일선물베스트 대치동유흥거리 revised 무료이미지다운로드 블랙잭전략 청천동노래방 직동출장마사지 안동mbc뉴스 해밀턴FC 김동완키 푹신푹신 케이블포설장비 한국vs북한 동패동나이트 섯다족보 별밤TV 다이어트자극사진크리스탈 안락동키스방 춘의동성인용품 재무제표모르면주식투자절대로하지마라 로또번호자동생성 소진영 스포츠토토싸이트 마케팅재택근무 구의동유흥거리 권선구성인게임장 권곡동북창pr 엠빅스에스지속시간 갠욕시 장기 유리룸주소 장외주식매매 트러스톤다이나믹코리아50 여자사춘기몸변화 라니아justgo반복재생 TCC동양주식 삼성테크원주식 누나사귀자 손연재갈라쇼 중동토킹bar 구하라설리 무수동키스방 재혼업체 한국성인에로영화 테크노카지노추천 JAVBRAZE 안영동성인용품 주식투자단순매매 피씨포커 동영상편집하는방법 FCViitorulConstanta 벤쿠버올림픽김연아 발기강직도 헬로우드림단점 실물예쁜연예인 포동퍼블릭룸 모라동레깅스룸 신공덕동퍼블릭룸 섹스추천사이트 바로보자 최신남자헤어스타일 범천동퍼블릭룸 여자가슴운동 용문동성인인형체험 전효성몸무게들통 티아라화영노출 00 섹시댄스곡 허봉넷 소셜데이팅 일본섹시화보 오픈월드엔터테인먼트연예인 온수동키스방 vhzj 하스미쿠레아 보라다리 목천읍안마 남자몸매자극사진 항동오피 손담비각선미 청소년봉사활동사이트 티파니 곽민정 여중생하두리 멱곡동대딸방 중곡2동홀덤대회 옥산동성인게임장 눈꽃레깅스코디 일본가슴커지는마사지 레이양 강원떡집 발호세 나이트룸 초코플레이어 50대여행 두구동룸싸롱 신동홀덤룰 광주유흥문화 나안동텍사스홀덤 전농나이트 금촌동립카페 산성동떡집 아는토렌트 악녀일기4정수정 일본야동동영상 스타킹써니목소리 수입구두 김진아이효리 아주예쁜여자 면목동방석집 최신성인일본만화영화 고잔동떡집 에프알텍주식 일반인엉덩이노출 세상에서가장무서운동물 S&T홀딩스주식 윙크부끄부끄 대구애인 kbs9시뉴스아나운서 커플수영복 신길5동성인오락실 신부동토킹bar wink kt[옥스프링] 신동희 서양노모포르노 송정동오마하홀덤 괴안동홀덤대회 폴란드 길동홀덤카페 정종철몸짱 십정동키스방 30대후반 토토마켓 다이소속옷정리함 당인동홀덤족보 양말제작 북면퍼블릭룸 영화속노출 마달동텍사스홀덤 속옷추천 메이플스토리예쁜여자 동선동대딸방 여자연예인머리스타일 김혜선기상캐스터노출 마장동유흥거리 사간동포커고수 양상동유흥문화 누나곰 오르가즘흥분 공주옷입히기 안현동홀덤카페 부대동오피 학의동레깅스룸 부수동레깅스룸 곽현화선정성논란 아틀레티코투쿠만 섹시란제리걸 세계미모랭킹100위 군자동성인오락실 일직동포커고수 잡주는없다 송풍동성인게임장 세희 현아현승애정행각 교복살색스타킹 개인택시수입 태장동홀덤카페 여자치마정장 영주동토킹bar 코버스 어현동텍사스홀덤 구의2동모바일홀덤 화장품 오피야 벨트 보이프렌드영민광민 안성성인게임장 야한영화사이트 박해미출렁 북가좌동홀덤족보 신민소 신동오마하홀덤 2012파워블로그 여자찜질방속옷 토렌트큐큐 5000만원굴리기 캐논인물사진 초등학생복근 강상면모바일홀덤 상도2동성인오락실 무한도전은혜갚은제비 패션모델 인터넷바다이야기 폴미 금광동떡집 수지인싸포커 에스에스딸 슈가 묵호진동홀덤바 박은지요가 홈쇼핑관련주 오션최신버전 아르세날데사란디 풍남동홀덤펍 알마겔 룸BAR 예쁜여자를봤을때남자들의실... 놀고가 이화동인싸포커 청담동성인게임장 동방신기일본연예인 과천동오피 초산동오마하홀덤 네오위즈주가 당산동3가성인게임장 그곳에서서가사 임당동성인오락실 탄방동퍼블릭룸 화곡8동홀덤카페 노출귀요미송 미로면성인오락실 보지빨자 정유정 도선동성인게임장 윤광선 클럽음악 영통동북창pr 싸이새mr 미아동홀덤족보 한화케미칼목표가 신대방2동모바일홀덤 ev-f500 성인비디오판매점 김현중정용화 무실동홀덤족보 서수면포커고수 유천동오마하홀덤 외국야한영화 레이튼미스터비디오 동안구모바일홀덤 가장동유흥주점 증권가찌라시연예인 증권시주식동 옥산면오마하홀덤 손담비미첬어 옥천동성인게임장 노암동홀덤카페 중앙동포커고수 우리결혼했어요유니나 반월동홀덤펍 인기가요티아라방송사고 고덕동카지노펍 일본AV배우/품번검색 가장동홀덤룰 롤러코스터99화 강심장이해인 윙크티비레이카 찰칵 대치1동홀덤바 해운대노래방 세희네야동 명산동카지노펍 뉴스속보 mbc살인 천안함 용문동키스방 합사줄추천 카지노주소 수성동홀덤펍 합동모바일홀덤 명품추천 나루토내블로그 화곡3동인싸포커 문산성인오락실 하왕십리동토킹bar 우결정용화 원서동홀덤대회 산다라박펜디가방 북산면성인게임장 패떳이효리 갈천동홀덤대회 크리스탈송 javsin 범일동안마 교하동리얼돌성인인형 중화산동포커고수 구평동방석집 ck드로즈 2011수능정답수리영역 파주홀덤대회 플스게임 신기면텍사스홀덤 왕리홍 전염병관련주 동부로봇주식 추천사이트 씹씹리얼돌 충현동텍사스홀덤 중동포커고수 손담비눈물이주르륵뮤비 연예인팬티노출모음 용인오피 부암동성인오락실 일본아나운서노출 여자팝송추천 본오동떡집 FC볼렌담 삼각동레깅스룸 이웃집남자 분위기띄우는랩 블로그스크랩이벤트 김여림 koreasextube 아이리스백지영 고두림성괴 반짝반짝빛나는한지우 라디오스타유이 색시야동보기 월곡2동홀덤바 skgirl 성인용품 풍납동립카페 사정동카지노펍 정가은홈피 리베리구자철 미장동홀덤바 웅천읍립카페 지곡동성인오락실 걸그룹노래추천 akb0048 점양동성인인형체험 홍은2동오마하홀덤 적각동카지노펍 홍제2동홀덤카페 입생로랑숄더백가방 색스포털 논현2동홀덤펍 장기본동성인게임장 중학동오피 블루투스관련주 베니툰 승리복근 부전동나이트 정상동텍사스홀덤 사직동나이트 파일구리공유 영원면포커고수 성형외과가슴 다가동모바일홀덤 성복동인싸포커 수원노래주점 초량동풀싸롱 mbc뉴스다시보기 암사3동성인오락실 양평오피 야구토토결과 1월최신 유진 요시키피아노 수송동홀덤펍 부암동건마 원당동성인게임장 산곡동퍼블릭룸 지숙직캠 무서운이야기샤워하는누나 봉의동인싸포커 시노펙스주가 상봉동리얼돌성인인형 단계동홀덤카페 소녀시대외모순위 걸티비 도당동오마하홀덤 시크릿징거하체 백지영짝퉁 전망좋은집 유노윤호복근 시야율 하반신 신길7동홀덤카페 테스토니지갑 롤리스킨 화정동홀덤펍 FK테플리체 IWC포르토피노 매룡동토킹bar 야마구치리코 섹시한여자엉덩이사진 색스오르가즘 풍기동안마 BT&I주식 여성빅사이즈수영복 마크제이콥스쇼퍼백 남양동성인오락실 설악면홀덤펍 전우치영화 갈현동나이트 신교동성인오락실 sexhardcore 영진약품주식 씨스타다솜성형전 토토센터 에르메스가방 괴안동대딸방 TWISTEDPORN 색스앤더시티다운로드 중앙동텍사스홀덤 좌천동키스방 예쁜여자영어이름 에르메스남성시계 연예인섹시화보 일본생리대 원천동성인오락실 범일동안마 옥산동포커고수 사당1동텍사스홀덤 페티쉬사이트 강승윤아이돌 용정동포커고수 도화동홀덤카페 애프터스쿨flashback안무느리... 구래동룸싸롱 금지면홀덤바 레인보우텔미텔미 고양성인게임장 소녀시대제시카동영상 소유글래머 무료성인사이트.에로스아시아링크 소격동포커고수 백산동홀덤바 먹튀바다 먹튀신고 웃긴축구짤방 에릭여자친구 휴지킹서버 야오이and하드 강심장태연선배 한미약품비아그라 배우김혜수 색스콘돔 덕지 태봉동토킹bar 개인사업자투자 라차부리 일본남자속옷 올림픽TV 먹튀폴리스검증업체 윙크티비아이린 이지애 아작시오GFCO 악동광행 샤르코드 던스 구성동룸싸롱 sport 오리엔탈카지노 허영생life 왕완비 노우모 데이트레이딩기법 먹튀검증스포위키 55토토 다소곳 19소설 무료로또조합시스템 박보람반전몸매 먹튀폴리스검증업체 DUDNDKFQK 대치동풀싸롱 홍익동성인인형체험 쇼음악중심티아라컴백 이미지메이킹(주) 나쁜피 비스트자체mr제거 성포동풀싸롱 에이핑크뉴스시즌3 슈어맨계정 번동오피 메이플연예인머리 바카라따는법 팔경락 네이버통합검색오류 미호동풀싸롱 망우동성인게임장 섹시미녀 서울워커힐카지노 여자빨기 현물현금 에이스하이텍주식 포토샵스티커 학장동퍼블릭룸 파워볼 로또통신 글로벌채팅 4학년교육방송 섹스공화국 먹튀닷컴 요시키결혼 하계동떡집 알씨사진용량줄이기 한솔인티큐브주식 CS마리티모B 생리할때 방배동건마 일본카페 전동릴 로또잘하는법 신방동아로마마사지 논현동유흥주점 먹튀검증사이트먹튀닷컴 인천수상택시 현저동건마 황민 루이비통시계이미테이션 무한도전빅뱅움짤 단기추천주 누드만화 마케팅정보 메이저놀이터순위 지숙담배 슈어맨배너먹튀 가지안테프부육셰히르스포르 보드보드 일본여자옷벗기기게임 충격화상채팅 라이브스타아리 한성엘컴텍주식 디스패치원빈이나영 일반인노출걸 해외선물계좌개설 해운대도끼 장존동북창pr 아이리버주식 노출과다 메이저놀이터순위 슈어맨같은곳 고딩청순글래머 신설동립카페 팬티속풍경 먹튀수사대 크레이지택시2 술집도우미 인라인k2무료성인사이트 h&m남성 다방 SOCIALDATING 은계동성인용품 활근보 레이싱겅누드 화성인g컵녀김은영 먹튀검증스포위키 페페러브젤 클라우드펀딩 고야드머니클립 하남건마 송중동풀싸롱 만화쇼콜라 소립자우엘백 먹튀폴리스심바 모아따 둔촌동유흥거리 야외섹스성인촌 딸잡go링크 풍세면안마 하이마트psp 안전놀이터모음 주식거래세 로또많이나온숫자 홍도동유흥문화 나가요 번동오피 대방동대딸방 로또당청번호예상 캠으로사진찍기 얼짱토토 외국여승무원 네이버섯다 로도복권 중구나이트 레인보우텔미텔미움짤 먹튀보증업체 SKRKDY 다방알바 안성리얼돌성인인형 어린이스포츠브라 치킨창업대출 알힐랄 lpg윤아 괴안동노래방 방동출장마사지 스포츠토토 노량진동풀싸롱 비아그라사는법 비아그라와시알리스 김옥빈폭주 먹튀폴리스검증업체 신라케이블방송 무료섹스동영상 에이핑크윤두준사촌동생 국내주식시장 로또1등비결 구르마넷우회 시크릿한선화과거 7천만원투자 가족놀이터 오류출장안마│온수출장안마│역곡출장안마 [1이닝무득점]콜로라도 역곡동립카페 철수넷일본야동 듀퐁라이타소리 슈가밀크 bj빙빙 한은정성형전 박형식남지현 엑스돌 용운동풀싸롱 학생팬티 3D릴게임 유료체팅 비도박 데일리룩블로그 남곡동안마 사랑합니다싸이 50대트로트 서종면토킹bar 노후자금 남성구찌시계 황진이 증권가찌라시이승기 천동건마 반편성고사 설운동오피 나는펫시즌7다시보기 중앙동대딸방 무한도전베스트 가수아이리스 재경움짤 김민경접대 항돈이 부평동나이트 토렌트티티 페라가모신상가방 울산번개팅 please 수지학교 레깅스위에 남포동출장마사지 초읍동떡집 구찌장지갑지갑222736 화류계사이트 좀비콤비 가벼운동영상플레이어 성주면대딸방 효창동토킹bar 쌍봉댁 CFP HK스탁론 로또맞는법 미열 현암동나이트 주식초고수 밤열한시닷컴커뮤니티 피망게임순위 일본여자보지 돈잘모으는방법 당리동풀싸롱 질 오피클럽 엠게임주식 섹시한사쿠라 전자복권 빅사이즈남성수영복 반영구헤어라인가격 청학동건마 주님같은반석은없도다 비아그라구입방법 대덕동성인게임장 사동립카페 용강동대딸방 여고생쩍벌 hypersexed 여대생얼굴 풍요 5min 블랙잭노하우 로또2등당첨점 베트남지수 cream 가정동방석집 걸스데이티저 클리블랜드 꽃무늬프릴비키니 원더브라사이즈 하의실종사진 코코포토 백학면키스방 찬송가무료듣기 강릉유흥 야모닷컴 대여 포도닷컴 성교방법 법곡동레깅스룸 신사동유흥문화 누리그라구강붕해필름50MG COLD1 빨조넷 싸이블로그스킨 황민우 주가와거래량 김제동반전몸매 소리넷주소 주식공부동영상 알펜시아리조트페이스북 에이플러스바카라 야만닷컴 노출화보사이트 밤에남자새주소 서현몸매 일본유명한가수 증권TV 초량동건마 팔라독정식판무료설치 사당동유흥주점 신대동방석집 키컸으면 거제모임 북한의생활모습 범천동오피 오토마트땅따먹기 문서아르바이트 점양동가라오케 성성동풀싸롱 weezer 갭남아팬티 yes전효성 루리플러스 대구다음 세상에서가장웃긴게임 천안한국마사회 검산동출장마사지 송지선아나운서 대박천황 bj서윤 헥토파스칼 맨토 비키 vporn일본야동 안영동노래방 일본선물시장 울림엔터테인먼트 빤스녀 매의눈 독산동유흥주점 라이브69TV 지축출장마사지 레이싱걸팬티노출 로또볼 증권매매수수료 주식고급정보 인터넷복권구매 누드영화 아이돌게이커플 떡마차서양야동 남성오르가즘 씹구닷컴 섹스매니아 코리아그라비아화보김성희 sex게임 토렌트이슈 크라임 JAVJOB트위터 시노자키아이돼지 대형주 가슴통증 광고가 부전동떡집 가산동성인용품 상일동유흥거리 실시간토토 성인식 토토달리기 로또프로그램 움짤만들기 아이팟동영상인코딩 아비루유 소라바다서양야동 sexforyou 직장인재테크 외삼동떡집 실전게임 위탁모집 비키니완판녀쇼핑몰 kokia앨범 홀덤족보 청계동리얼돌성인인형 섹시알몸사진 영등포동3가홀덤족보 맞고 토토홍보 안암동4가성인게임장 소룡동인싸포커 LG이노텍주식 스포츠토토 여성빅사이즈수영복 세븐포커 벤틀리시계 구로동홀덤바 여자누드사진집 양현동유흥주점 신길7동홀덤대회 항만 막계동안마 90년생아이돌 강동구레깅스룸 도봉동안마 통의동모바일홀덤 자양3동텍사스홀덤 추천성인사이트 하장면포커고수 실전게임 일진그룹 크레이지택시1 명륜3가모바일홀덤 섹스동영상보여주세요 판암동립카페 덕지동나이트 고잔동성인오락실 노암동홀덤카페 가리봉동노래방 발렌시아가가방 동안구홀덤카페 상도4동홀덤카페 유성유흥주점 교촌동키스방 먹튀검증 태그호이어까레라헤리티지 똥싸는여성 g컵녀유출 트러블메이커마마 승무원동영상 송동면인싸포커 서교동홀덤펍 간이옷장 발리자유여행 대구잘하는미용실 대명동포커고수 politician 용안면텍사스홀덤 인후동홀덤룰 원더풀홀덤 운산동성인오락실 월락동카지노펍 선단동카지노펍 전시회 만경읍홀덤카페 개복동홀덤바 휴대폰아이콘 가인snl움짤 오구리슌키 여자초등학생수영복 수지나이트 조현영텔미텔미 종로4가동모바일홀덤 풀팟홀덤 포커홀덤 파멜라몰래카매라보기 세미룸 사동성인오락실 오류1동성인오락실 당주동홀덤펍 궁정동카지노펍 큐로컴주식 목천동포커고수 어현동성인게임장 역곡동방석집 롤러코스터시청률 용연동레깅스룸 천동떡집 방화3동모바일홀덤 현금홀덤사이트 운동법 서정동카지노펍 흑암동홀덤대회 더블d컵 멀버리남자지갑 석촌동아로마마사지 안산성인게임장 관설동포커고수 엉덩이주사소설 무한도전요요 성인용동영상보는곳 아사다마오의상 다가동홀덤족보 대만배우순위 압구정홀덤 흥업면성인오락실 공부사이트 바보스탁 텍사스홀덤 맞고 청운동노래방 설악면풀싸롱 구하라몸무게 문지동퍼블릭룸 경운동홀덤바 세븐포커 마카비페타티크바 수지허리 송지효남자친구 홀덤 여자연예인사복패션 청소면퍼블릭룸 장대동유흥거리 마크바이마크제이콥스가방 g컵뜻 은정노출 도쿄택시보기 삼보판지주식 목천동오마하홀덤 남방동포커고수 성산면카지노펍 용운동방석집 독일유명한가수 유저 하이로우 연산동아라비안나이트 신인여가수앨범 오산동토킹bar 우장산동카지노펍 성내1동카지노펍 중앙동홀덤카페 쉬운춤 인물사진 일산동구아로마마사지 회현면성인오락실 파추카 가슴게임 별양동레깅스룸 소사동홀덤펍 포커홀덤 김은영 그리기쉬운동물 풍남동홀덤바 일산서구키스방 고척동오피 adulttube 벌써보고싶어듣기 지곡동카지노펍 두산엔진주식시세 발산1동포커고수 대림2동포커고수 후평동홀덤대회 오산동홀덤대회 여자발가락 매충 인피니트하의실종 브아걸snl 선양동홀덤바 모공베이스 요암동풀싸롱 페이퍼코리아주식 청산면홀덤카페 동산동성인게임장 우아동오마하홀덤 노송동홀덤룰 볼만한야한동영상 드림콘서트빅뱅 SNL코리아 창천동홀덤펍 파인드토렌트 경륜장 금 뇨기과 여자레슬링하며 직찍 처제의 욕정 낙원 공짜폰게임 페니스강화약 가수 연애인사진첩 소라의가이드섹스이트 빅스타성인용품 게임방법 고사랑 남자자위기구사진 합성 야어소설 1처녀들의 희롱 무료여성강간만화 최신영화프로 트랜스젠더수술 성인휴개실 라이브쇼 탈의실셀카마이데일리 상태 지붕뚫고하이킥 회 다시보기 본네뷸라 실억계녀 섹시망사스타킹 성인친구 이보희 몸매 해적단와레즈 페티쉬캠 성인게시판무료 완전무료섹스동영상 합성엔진오일 캐스트롤 어우동 케이블tv 인터넷느림 슈 야한오줌 가장섹쉬한여성 세이챗 제스트라 무료사진 필리핀 밤문화 알맹이몰 아줌마엉덩이보지애액 하유선 야한 이화선 베드신 꿀벅지 별거 화상채팅사이트 섹스공짜동영상 1한일본 메가패스광고모델 삼성차 후속모델 노출일반인 남자의자지와여자의보지그리고섹스 김선정 1일본스타킹 여성트레이닝 실시간디오방 여성건강과 휴대폰요금 래이싱걸노출 사진엽기 팝핀배우기 가슴영화 은꼴 섹시 트리쉬알몸보기 츠나데나루토망가 엄마자위 여자shcnf 자우l 매로나 무료동영상 기본야동 만화책꽁짜 녀망가 색시몽리턴즈다시보기 아줌마거시기 학대 회원가입안하고 psp영화다운로드 엄마음부 tkznfkrktma 리니지혈마크 페티쉬캠 꼬추빨기 스타킹신은여자들의사진 게시판야동 누나의행위 http:// 러브일본만화 쾌락설 청량리역 여의도단란주점 샤크라 프로스페스 키모라 시몬
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