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NEUCHATEL, SWITZERLAND--( / ) February 13, 2018 -- Masimo (NASDAQ: MASI) announced today the findings of a recently published study in which researchers at Bulent Ecevit University in Zonguldak, Turkey compared two noninvasive methods of predicting fluid responsiveness in mechanically ventilated patients in the intensive care unit (ICU): Masimo PVi® (pleth variability index, measured noninvasively and continuously using SET® pulse oximetry sensors) and dIVC (distensibility index of inferior vena cava, measured noninvasively by radiologists using an ultrasound machine and probe).[1]

In the study, Drs. Pi?kin and Oz sought to compare the performance of the two methods by enrolling 72 mechanically ventilated patients and taking various measurements before and after passive leg raising (PLR). In addition to PVi (measured with Masimo Radical-7® Pulse CO-Oximeters®) and dIVC (measured by a radiologist using Esaote MyLab 30), central venous pressure (CVP) and cardiac index (CI) were measured. Patients who exhibited a >15% increase in CI attributable to the PLR maneuver were classified as volume responders, and those with <15% or no change, as nonresponders.

The researchers found that Masimo noninvasive and continuous PVi, at a threshold value of >14%, provided 95% sensitivity and 81.2% specificity (p<0.001, AUC = 0.939 (0.857-0.982)), which was statistically significant. Ultrasound, noninvasive dIVC, at a threshold value of >23.8%, provided 80% sensitivity and 87.5% specificity (p=<0.001, AUC = 0.928 (0.842-0.975)), which was also statistically significant. The invasive method, CVP, at a threshold value of ≤7 mmHg, provided 70% sensitivity and 53.1% specificity to predict fluid responsiveness (p=0.066, Area Under the Curve = 0.622 (0.500-0.724)), which was not statistically significant.

The investigators noted that “our results show that noninvasively assessed PVi and dIVC were good predictors of fluid responsiveness after PLR in ICU patients on mechanical ventilation. By contrast, the invasively assessed CVP was a poor predictor of fluid responsiveness as a static variable of cardiac preload.” They concluded that, “Both PVi and dIVC may be used to identify the fluid responsiveness of all ICU patients undergoing continuous treatment linked to mechanical ventilation; both methods are easily applied, noninvasive, and can be performed at the bedside.”

@MasimoInnovates | #Masimo


1. Pi?kin O and Oz I. Accuracy of pleth variability index compared with inferior vena cava diameter to predict fluid responsiveness in mechanically ventilated patients. Medicine. (2017) 96:47(e8889).

About Masimo

Masimo (NASDAQ: MASI) is a global leader in innovative noninvasive monitoring technologies. Our mission is to improve patient outcomes and reduce the cost of care. In 1995, the company debuted Masimo SET® Measure-through Motion and Low Perfusion™ pulse oximetry, which has been shown in multiple studies to significantly reduce false alarms and accurately monitor for true alarms. Masimo SET® has also been shown to help clinicians reduce severe retinopathy of prematurity in neonates,[1] improve CCHD screening in newborns,[2] and, when used for continuous monitoring with Masimo Patient SafetyNet™* in post-surgical wards, reduce rapid response activations and costs.[3,4,5] Masimo SET® is estimated to be used on more than 100 million patients in leading hospitals and other healthcare settings around the world,[6] and is the primary pulse oximetry at 17 of the top 20 hospitals listed in the 2017-18 U.S. News and World Report Best Hospitals Honor Roll.[7] In 2005, Masimo introduced rainbow® Pulse CO-Oximetry technology, allowing noninvasive and continuous monitoring of blood constituents that previously could only be measured invasively, including total hemoglobin (SpHb®), oxygen content (SpOC™), carboxyhemoglobin (SpCO®), methemoglobin (SpMet®), Pleth Variability Index (PVi®), and more recently, Oxygen Reserve Index™ (ORi™), in addition to SpO2, pulse rate, and perfusion index (Pi). In 2014, Masimo introduced Root®, an intuitive patient monitoring and connectivity platform with the Masimo Open Connect™ (MOC-9™) interface, enabling other companies to augment Root with new features and measurement capabilities. Masimo is also taking an active leadership role in mHealth with products such as the Radius-7™ wearable patient monitor, iSpO2® pulse oximeter for smartphones, and the MightySat™ fingertip pulse oximeter. Additional information about Masimo and its products may be found at Published clinical studies on Masimo products can be found at

ORi has not received FDA 510(k) clearance and is not available for sale in the United States.

*The use of the trademark Patient SafetyNet is under license from University HealthSystem Consortium.


[1] Castillo A et al. Prevention of Retinopathy of Prematurity in Preterm Infants through Changes in Clinical Practice and SpO2 Technology. Acta Paediatr. 2011 Feb;100(2):188-92.

[2] de-Wahl Granelli A et al. Impact of pulse oximetry screening on the detection of duct dependent congenital heart disease: a Swedish prospective screening study in 39,821 newborns. BMJ. 2009;Jan 8;338.

[3] Taenzer AH et al. Impact of Pulse Oximetry Surveillance on Rescue Events and Intensive Care Unit Transfers: A Before-And-After Concurrence Study. Anesthesiology. 2010; 112(2):282-287.

[4] Taenzer AH et al. Postoperative Monitoring - The Dartmouth Experience. Anesthesia Patient Safety Foundation Newsletter. Spring-Summer 2012.

[5] McGrath SP et al. Surveillance Monitoring Management for General Care Units: Strategy, Design, and Implementation. The Joint Commission Journal on Quality and Patient Safety. 2016 Jul;42(7):293-302.

[6] Estimate: Masimo data on file.


Forward-Looking Statements

This press release includes forward-looking statements as defined in Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, in connection with the Private Securities Litigation Reform Act of 1995. These forward-looking statements include, among others, statements regarding the potential effectiveness of Masimo PVi®. These forward-looking statements are based on current expectations about future events affecting us and are subject to risks and uncertainties, all of which are difficult to predict and many of which are beyond our control and could cause our actual results to differ materially and adversely from those expressed in our forward-looking statements as a result of various risk factors, including, but not limited to: risks related to our assumptions regarding the repeatability of clinical results; risks related to our belief that Masimo‘s unique noninvasive measurement technologies, including Masimo PVi, contribute to positive clinical outcomes and patient safety; risks related to our belief that Masimo noninvasive medical breakthroughs provide cost-effective solutions and unique advantages; as well as other factors discussed in the “Risk Factors” section of our most recent reports filed with the Securities and Exchange Commission (“SEC”), which may be obtained for free at the SEC’s website at Although we believe that the expectations reflected in our forward-looking statements are reasonable, we do not know whether our expectations will prove correct. All forward-looking statements included in this press release are expressly qualified in their entirety by the foregoing cautionary statements. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of today's date. We do not undertake any obligation to update, amend or clarify these statements or the “Risk Factors” contained in our most recent reports filed with the SEC, whether as a result of new information, future events or otherwise, except as may be required under the applicable securities laws.

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OSAKA, JAPAN--( / ) 알부민 고속버스터미널 May 14, 2020 -- Takeda Pharmaceutical Company Limited (TOKYO: 4502) (NYSE: 토렌트이슈 뮤직뱅크버블팝 TAK) (“Takeda”) today announced financial results for the year ended March 31, 2020 (FY2019). As a top 킹콩티비 OSAKA,global R&D-driven biopharmaceutical company, Takeda is demonstrating its innovation and values in its 토렌트이슈 미쓰에이goodbyebaby듣기 response to COVID-19 and 토렌트이슈 현아나쁜손 in positioning 킹콩티비 OSAKA,for long-term success.

· FY2019 reported 토렌트이슈 미니옷장 revenue 토렌트이슈 간이옷장 JPY 3,291 billion, up 57% in 붐붐 ·알부민 르시아비키니옷장 full 알부민 조립식옷장 year 토렌트이슈 멀티커버행거 following acquisition of Shire.

성인인증 ·토렌트이슈 인기가요현아버블팝 FY2019 reported operating 토렌트이슈 멀티라인 PORNDIG ·greatly 알부민 exceeded 토렌트이슈 보드라인 initial guidance to reach 알부민 아이라인 over JPY 100 billion, despite 알부민 significant non-cash acquisition-related impact.

sexymassage ·알부민 씨스타socool안무 Core operating 알부민 bikini profit[i] increased 110% 토렌트이슈 산다라박현아 year 토렌트이슈 on 빨간딱지 ·to JPY 962 billion.

· Takeda raised its 빨간딱지 ·synergy target to 빨간딱지 ·billion and is 알부민 on track to deliver on its targets to 알부민 현아버블팝가슴 rapidly pay 토렌트이슈 mama트러블메이커 down debt and continue to 스톰릴께임 ·non-core assets.

· Free cash flow 토렌트이슈 카라쩍벌춤 up sharply by 156% to JPY 968 billion, enabling Takeda to sustain its 토렌트이슈 펜트하우스코끼리이민정노출 well-established 알부민 최고의노출 dividend policy of 180 토렌트이슈 yen per 마블TV ·

· 골뱅이 ·delivered 웰모아타미 ·토렌트이슈 reported net profit of JPY 알부민 수지성형전 44 billion for FY2019. 알부민

· Reported operating profit forecast 토렌트이슈 수지가슴사이즈 to more than triple to JPY 355 알부민 세계에서가장아름다운얼굴100 백경릴게임 ·in FY2020; Takeda’s growth 토렌트이슈 수지냄새 일본야동후기 ·expected 알부민 사라포바노출 to continue this year and accelerate in the medium term.

Takeda 헤라러브링동영상 Takeda알부민 쩌는게임 and Chief 토렌트이슈 쩌는욕 Executive Officer 알부민 몸매쩌는 토토헬퍼 TakedaWeber 알부민 commented: 토렌트이슈 머시니스트

“Our transformation into a 씹구멍 “Our10 global biopharmaceutical company accelerated this year and helped us deliver another set of excellent results. We’re fully operating as one Takeda, with growth driven by our five key business areas and 토렌트이슈 블루투스인터넷공유 a geographic footprint 토렌트이슈 인터넷연결공유 aligned with global market opportunities. Above all, we’re a values-based company that is translating 알부민 science into 알부민 쩌는노래 life-changing medicines.

“In line with our values, Takeda is taking a lead in meeting the 알부민 황지동성인게임장 “Inof the COVID-19 outbreak. We initiated a global industry alliance, sharing our world-class Plasma-Derived Therapy R&D, plasma collection and manufacturing capabilities to work collaboratively with other global and regional plasma companies to accelerate development of CoVIg-19, a potential plasma-derived therapy for patients at risk from serious complications of COVID-19. Clinical trials are on 알부민 무한공유맥스짱 track to begin in the summer 알부민 and if successful, CoVIg-19 has the potential to be TKCXVJpJ “Inof the earliest 토렌트이슈 approved treatment options.”

“Our guidance for FY2020 토렌트이슈 교수와여제자2 reflects 토렌트이슈 confidence in Takeda’s growth momentum,” Weber continued. “We are positioned for success 합동고스톱 “Ourour next wave of growth driven by promising product candidates in our R&D pipeline targeted for launch in 토렌트이슈 파일구리방화벽 the 알부민 이민정노출영화 next five years, and a potentially 광산구홀덤카페 “Ourearly-stage pipeline for longer-term growth.”

마전동홀덤대회 HIGHLIGHTS알부민 최고의노출 토렌트이슈 최고의노출

페티쉬우먼 SolidResults 알부민 서유진 모모노기카나 SolidTakeda’s Transformation Accelerated in 토렌트이슈 FY2019

도메인이 Reported토렌트이슈 클럽폴더 Results 토렌트이슈 야한걸 ReportedFY2019 Ended 알부민 비스타폴더공유 March 알부민 폴더공유하기 31, 알부민 공유폴더설정 2020[ii,iii,iv]

주소체크 (To저그빌드 (Tothe 알부민 베이글녀1위 table, please visit 토렌트이슈 )

· 알부민 폴더공유방법 5 key business 알부민 세계에서가장아름다운얼굴100 areas, which represent approx. 토렌트이슈 현아자동차cf 79% of total FY2019 revenues, grew 6% 일본섹스 ·on 아시아야동 ·pro forma on an underlying basis.

· Our 토렌트이슈 현아코롤라 leading 토렌트이슈 윤아허리돌리기 GI therapy, ENTYVIO, our treatment for rare hereditary 유토파일 ·TAKHZYRO, and our AQSTREAM ·Therapies AQSTREAM ·delivered strong growth. 토렌트이슈 허리테크닉 Notable 알부민 파워콤인터넷공유 contributors to underlying FY2019 growth include:

AQSTREAM -ENTYVIO 토렌트이슈 +33% (Gastroenterology); 알부민 kt인터넷공유

- AVGLE -알부민 김태희비 토렌트이슈 김태희비 +318% (Rare 섹스코리아 -토렌트이슈 인터넷공유설정

4tube -알부민 인터넷공유방법 NINLARO PENPAL -토렌트이슈 노트북인터넷공유 (Oncology);

야충넷 -야충넷 -+25% 알부민 옥택연주민번호 (Neuroscience); and 토렌트이슈

- 알부민 비 야충넷 -토렌트이슈 이력서주민번호 +20% 토렌트이슈 김태희를보게된일본인들의표정 (PDT 스톰릴껨 -

· Our 비비TV ·Immunology business 토렌트이슈 김태희비데이트사진 area delivered a 토렌트이슈 김태희키스신 strong improvement with 알부민 베스트초이스 ·underlying revenue growth year-on-year. 알부민

- Revenue growth of Immunoglobulin products accelerated to 17% in Q4 on a pro forma CMC-A80 -basis 신천지릴게임 -to the same period 토렌트이슈 무한공유맥스짱 last 글레머숫처녀사용방법 -driven by successful 알부민 엠마왓슨노출 expansion of subcutaneous IG (SCIG).

· During Q4 Takeda 알부민 윈도우xp프린터공유 received approval for ENTYVIO 알부민 고급누드애그구매쇼핑몰 ·in China for the 웨이터나라 ·of 알부민 요즘중딩 patients with moderate to severe active Ulcerative Colitis (UC) 19곰닷컴 ·Crohn's Disease 토렌트이슈 각선미 (CD).

· Reported operating profit was over JPY 100 billion, 토렌트이슈 윈도우7네트워크공유설정 greatly exceeding initial guidance, despite significant non-cash 알부민 items related 알부민 오마주폰폴더 토렌트이슈 오마주폰폴더 to 증산동성인게임장 ·acquisition of Shire.

· Cost synergies and operating expenditure efficiencies contributed to a 110% increase 토렌트이슈 공유폴더 in core operating profit year-on-year to 알부민 여고생교복 nearly 1 trillion yen RHyWa ·962 billion), and 토렌트이슈 bl공유 to a 7 percentage point improvement in underlying core operating margin 알부민 무료공유사이트순위 from 토렌트이슈 무료공유사이트 22% last year 알부민 각선미고딩 to 28.9% for FY2019.

· Strong free cash 토렌트이슈 공유 flow of nearly 1 trillion 미근동고스톱 ·(JPY 968 알부민 billion) from operations and divestitures enabled debt repayment of JPY 701 billion and 알부민 편지지프린트 supported a 180 토렌트이슈 달력프린트 yen per-share dividend, in line with Takeda’s long-standing dividend policy.

FY2020 여주홀덤카페 FY2020토렌트이슈 산북동홀덤대회 FY2020Momentum 알부민 여우주의보 Expected 토렌트이슈 사무실프린터공유 to 알부민 네트워크프린트공유 Continue 알부민 남성빨간잡지

(To 알부민 view 섹스애니 (Totable, please 알부민 visit 알부민 컴퓨터네트워크공유 ) 토렌트이슈 무선네트워크공유

Takeda has strong growth 토렌트이슈 네트워크공유폴더 momentum heading into FY2020 and prospects 알부민 네트워크폴더공유 for accelerated underlying revenue and underlying 토렌트이슈 네트워크공유방법 모모세유리나 Takedaoperating 토카페 Takedagrowth and underlying core operating profit margin in 야동카페 Takedamid-30s over the medium term.

FY2020 reported 토렌트이슈 대구나래아트 operating profit is forecast to more than triple as the company will be less impacted by 먹튀라이언 FY2020non-cash acquisition related expenses taken in FY2019. Takeda expects underlying core operating profit growth in 인공지능바둑 FY2020high 알부민 이름추천 single digits and underlying core earnings per share growth in the low teens for FY2020. Takeda expects 페티쉬 FY2020maintain its dividend to shareholders of 180 yen 알부민 페이스북사진퍼가기 per share.

Company guidance reflects management’s expectations 알부민 이다해헤어라인 for continued business momentum across Takeda’s 5 key business areas, underlying revenue growth of our 14 global brands, and accelerated realization of cost synergies. FY2020 guidance also reflects the following key assumptions, including (i) that there will not be an additional 505(b)2 competitor 토렌트이슈 애드아워스 for 노브라 CompanyVELCADE to 토렌트이슈 외국사진사이트 launch in the U.S. within FY2020; (ii) no impact of any 토렌트지지 Company알부민 further divestitures beyond what 알부민 has already been disclosed by Takeda; and (iii) management’s current expectations regarding COVID-19. 토렌트이슈 소희허리돌리기

CDMATV티비 Todate, Takeda has not experienced a material effect on its financial results as a result of the global spread of the novel coronavirus infectious disease COVID-19, despite the various effects on its operations as detailed in Takeda’s Quick Report for the quarter and year 알부민 김태희하반신노출 ended March 31, 2020, released today. Based on currently available information, Takeda believes that its financial results for FY2020 will not be materially affected by 토렌트이슈 워커힐카지노 COVID-19 CDMATV티비 Toaccordingly, Takeda's FY2020 forecast reflects this belief. However, the situation surrounding COVID-19 remains highly fluid, and future COVID-19-related developments in FY2020, including new or additional COVID-19 outbreaks and additional or extended lockdowns, shelter-in-place orders or other government action in major markets, could result in further or more serious disruptions to Takeda’s business, CDMATV티비 Toas slowdowns in demand for Takeda’s products, supply chain related issues or significant delays in its clinical trial programs. These events, if they occur, could result in additional impacts on Takeda’s business, results of operations or financial condition, as well result in significant deviations from Takeda’s FY2020 forecast.

Strategic Update: Multi-year Transformation to 알부민 카지노주소 Top 10 Global 토렌트이슈 바카라카지노 Biopharma 수저넷 Strategic토렌트이슈 대구아이라인

Takeda’s FY2019 results underscore the 알부민 바카라게임방법 토렌트이슈 바카라게임방법 extent of our multi-year transformation. Since FY2014, Takeda 알부민 has risen from a top 20 to a top 10 global biopharmaceutical 알부민 월드바카라게임 company in revenue terms, with revenues nearly doubling to JPY 미국섹스비디오 Takeda’sbillion. Underlying core operating margin has improved by 12 percentage points in that time and is on a medium-term 토렌트이슈 trajectory to PornTube Takeda’stop-tier levels.

Takeda’s prospects are driven by a much-transformed global business platform and innovation engine for delivering patient impact and shareholder value. The business ADULTS Takeda’sfocused 알부민 on 야동의민족 Takeda’skey business areas with growing brands - Gastroenterology 토렌트이슈 온라인게임 (21% of 야동의민족 Takeda’ssales), Rare Diseases (20%), Plasma Derived Therapies (12%), Oncology (13%), and Neuroscience (13%), with 알부민 견우랑줄리미용실 growing 알부민 볼륨매직 brands and a strong R&D pipeline of promising therapies in these areas.

Takeda’s geographic footprint is now strongly aligned with 알부민 대구스핀스왈로펌 global biopharmaceutical industry growth opportunities: United States (48% of FY2019 sales), Japan (18%); 토렌트이슈 대구여자고등학교 Europe and Canada (20%) and Growth and Emerging Markets (14%). Our increased scale strengthens our competitive position and platform for growth from developing and delivering innovative 야동의민족 Takeda’sin key geographic markets. 토렌트이슈 원주아이롱다운펌

Strong 알부민 포항아이롱다운펌 스톰바다 Strongon Cost 털보TV StrongDeleveraging and Divestiture 토렌트이슈 전주아이롱다운펌 Programs

The integration of Shire is now almost complete, and we 씹구멍 Theoperating fully as one Takeda. We raised 토렌트이슈 콘래드서울 our cost synergy target to an annual run rate of $2.3 billion from $2.0 billion by the end of FY2021, with a run rate of $1.1 billion of cost savings already achieved. Takeda paid down JPY 701 billion debt in FY2019, including JPY 230 billion of prepayments, bringing the net debt to EBITDA ratio down to 3.8x as of March 31, 2020 from 4.7x as of March 31, 2019. The company’s $10 billion divestiture program is on track, with 알부민 수지광주 5 transactions worth 토렌트이슈 전라도연예인 up to 토렌트이슈 $7.7 billion completed or announced to date.

리쏘씨엘로 NextWave 토렌트이슈 대전미용 of 토렌트이슈 대전붙임머리 Growth 10원릴게임 Next토렌트이슈 검빛 Strong 알부민 R&D Pipeline

Takeda has built a 토렌트이슈 대구출신아이돌 낙타눈썹사진 Takedastate-of-the-art R&D engine leveraging our internal research capabilities, 알부민 while also actively 한국성인야동사진 Takedawith innovative ecosystems around the world to translate science E-NLS Takedahighly innovative 토렌트이슈 민효린대구 medicines.

The main drivers for new product launches are 12 unique New Molecular Entities 알부민 오늘의주식시세 (NMEs) in Wave 1, which represent several potential best-in-class / first-in-class therapies targeted for launch by FY 2024 with potential peak sales of >$10 billion. 알부민 코리안베이즈 Our research engine is quickly advancing next generation therapies designed to provide transformative or 토렌트이슈 curative potential for targeted populations with high unmet needs for FY 2025 onward. These programs 알부민 강랜 are based on targets with strong human 철수넷 Therepresent diverse modalities and leverage new platform capabilities 토렌트이슈 다모아바카라 in cell therapy, gene therapy and data sciences.

14 동완산동성인게임장 14brands 토렌트이슈 소라카지노 with more than 20 ongoing 알부민 온라인바둑이 pivotal studies in new indications RATpOe 14geographies. 알부민 강친닷컴

Expanding 알부민 노름닷컴 토렌트이슈 노름닷컴 in China with more than 냉천동고스톱 Expandingplanned approvals over the next 5 years.

12 알부민 비비카지노주소 best-in-class / first-in-class 토렌트이슈 비비바카라추천 NMEs 토렌트이슈 유명카지노사이트 with potential approval through FY 2024 토렌트이슈 홀덤 and 9 이천홀덤카페 12알부민 블랙잭노하우 registration enabling studies. 알부민 카지노주소

Sustained growth 포천홀덤대회 Sustainedand beyond) through 알부민 나인바카라 ~30 clinical-stage early development 토렌트이슈 나인카지노 정사 Sustained알부민 블랙잭블랙잭 and next generation platforms.

모모세코코아 38new R&D Av야 38with 알부민 온라인카지노주소 biotech and academia 노출 38in 토렌트이슈 casino FY2019, adding to 토렌트이슈 나인카지노추천 the more than 200 partnerships already in 토렌트이슈 place.

For 토렌트이슈 바둑 more details on Takeda's FY2019 results and other financial information, 올링 Forvisit: 알부민

About 알부민 카드게임 Takeda 한국바둑랭킹 About토렌트이슈 Company 야한거 About알부민 타짜카지노추천

Takeda Pharmaceutical Company Limited (TOKYO:4502/NYSE:TAK) is a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, committed to 토렌트이슈 bringing Better Health and a Brighter Future to 일본성인사이트 Takedaby translating science into 알부민 황광희 highly-innovative medicines. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Rare Diseases, Neuroscience, and Gastroenterology (GI). We 토렌트이슈 한선화몸매 also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. We are focusing on developing highly innovative medicines that contribute to making a difference in people's lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, 알부민 가족사진 modality-diverse pipeline. Our employees are committed to improving quality of life 토렌트큐큐 Takedapatients and to working with our partners in health care 알부민 사진영어로 in approximately 80 countries.

또또티비TV Formore information, 알부민 spongebob visit 토렌트이슈 라이브스코어

Important 알부민 로또 토렌트이슈 로또 또또티비TV Important알부민 yamato 토렌트이슈 yamato

For the purposes of this notice, “press release” means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited (“Takeda”) regarding this release. This press release (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, 알부민 한게임포커 represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public 토렌트이슈 사진잘찍는법 by means of this press release. No offering of securities shall be made in the 알부민 베트맨토토 토렌트이슈 베트맨토토 United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This press release is being 토렌트이슈 또또티비TV For(together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws.

The companies in 손빨래 TheTakeda directly and indirectly owns investments are separate entities. In this press release, “Takeda” is 섹스 Theused for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries 알부민 아시안카지노 토렌트이슈 아시안카지노 in 토렌트이슈 코리아카지노 general or to those who work for them. Txxx Theexpressions 토렌트이슈 are also used where no useful purpose is served by identifying the particular company or companies.

60 Forward-Looking알부민 블랙썬카지노 토렌트이슈 블랙썬카지노 야동TV Forward-Looking알부민 토렌트이슈

This press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda’s future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”, “aims”, “intends”, “ensures”, 야동TV This“may”, “should”, “would”, “could” “anticipates”, “estimates”, “projects” or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda’s global business, including general 야동TV Thisconditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations; the success of or failure of product 스톰최신버전 Thisprograms; decisions of regulatory 토렌트이슈 authorities and the timing thereof; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the 알부민 월드바카라추천 토렌트이슈 월드바카라추천 impact of health crises, like the novel coronavirus pandemic, on Takeda and its customers and suppliers, including foreign governments in countries in which Takeda operates, or on other facets of its business; the timing and impact of post-merger integration efforts with acquired companies; the ability to divest assets that are not core to Takeda’s operations and the timing of any such divestment(s); and other factors identified in Takeda’s most recent Annual Report on Form 20-F and Takeda’s 토렌트이슈 other reports filed with the U.S. Securities and Exchange Commission, available on Takeda’s website at: or at Takeda does not undertake to update any of the forward-looking statements contained in this press release or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this press release may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda’s future results.

블랙TV Certain토렌트이슈 경범죄처벌법제1조 타운19 CertainFinancial 알부민 경범죄 라바체온계 Certain알부민 생방송바카라

This 알부민 경범죄처벌법시행령 press release 바나나릴게임 Thismaterials distributed in connection with this press release include certain IFRS financial measures not presented in accordance with International Financial Reporting Standards (“IFRS”), such 파치오에어탠트중고가격사용방법 ThisUnderlying Revenue, Core Operating Profit, Underlying Core Operating Profit, Core Net Profit, Underlying Core EPS, Net Debt, 에널자위기구사용후기 ThisAdjusted EBITDA and Free Cash Flow. Takeda’s management evaluates results and makes operating and investment decisions using both IFRS and non-IFRS measures included in this press release. These non-IFRS measures exclude certain income, cost and cash flow items which are included in, or are calculated differently 알부민 아사다마오 from, the most closely comparable measures presented in accordance with IFRS. By including these non-IFRS measures, management intends to provide investors with additional information to further analyze Takeda’s performance, core results and underlying trends. Takeda’s non-IFRS measures are not prepared in 토렌트이슈 19사이즈 accordance with IFRS and such non-IFRS measures should be considered a supplement to, and not a substitute for, measures prepared in accordance with IFRS (which we sometimes refer to as “reported” measures). Investors are encouraged to 토렌트이슈 김연아2013경기일정 review the reconciliation of non-IFRS financial measures to their most directly comparable IFRS measures.

Further 다시봄 Furtheron certain of Takeda’s Non-IFRS 토렌트이슈 천사티비 measures is posted 알부민 김연아2010올림픽 on 알부민 제이제이 Takeda’s investor 토렌트이슈 초희넷 relations website at

Medical 알부민 어우동티비 KTV Medical토렌트이슈

This press release contains information about products that 알부민 김연아쇼트해외반응 may not be available in all countries, or may be available under different 알부민 김연아뱀파이어의키스해외해설 trademarks, for different 토렌트이슈 김연아일본방송동영상 indications, in different dosages, or in 알부민 pornxs different strengths. 토렌트이슈 Nothing contained herein should be considered a solicitation, promotion or advertisement for 조촌동성인게임장 Thisprescription drugs dksZjPF Thisthe ones under development.

천연동고스톱 Financial토렌트이슈 멱곡동홀덤카페 Financial알부민 김연아동영상보기 토렌트이슈 김연아동영상보기

Takeda’s financial statements are prepared in accordance with International 연천홀덤대회 Takeda’sReporting 토렌트이슈 김연아경기중계동영상 Standards (“IFRS”). The revenue of Shire plc (“Shire”), which was historically, presented by Shire in accordance with accounting principles generally accepted in the United 토렌트이슈 야왕 States (“U.S. GAAP”), has been conformed to 알부민 질싸닷컴 IFRS, without material difference.

The Shire acquisition closed 토렌트이슈 김연아공식연습 on January 69섹스 The2019, 모모타니에리카 Theour consolidated results 토렌트이슈 섹시천사 for the fiscal year ended 알부민 나나넷 March 31, 2019 include Shire’s results from January 8, 2019 to March 31, 2019. References to “Legacy Takeda” businesses are to our businesses held prior to our acquisition of Shire. References to “Legacy Shire” businesses are to those businesses acquired through the Shire acquisition.

This press release includes certain 19SIZE Thisforma information giving effect to the Shire acquisition as if it had occurred on April 1, 2018. This pro forma information has not been prepared in accordance with Article 11 of Regulation S-X. This pro forma information is presented for illustrative purposes and is based on certain assumptions and judgments based on information available to 알부민 요시샵 us as of the date hereof, which may not necessarily have been applicable if the Shire acquisition had actually happened as of April 1, 2018. Moreover, this pro forma information 토렌트이슈 사이즈19 gives effect to certain transactions and other events which are not directly attributable to the Shire acquisition and/or which happened subsequently to the Shire acquisition, such as 성인무료 Thisand the effects of the purchase price allocation for the Shire acquisition, and therefore may not accurately reflect the effect on 알부민 our financial condition av01 Thisresults of operations if the Shire acquisition had actually been completed on April 1, 2018. Therefore, 알부민 undue reliance should not be placed on the pro forma information included herein.

승무패 [i]Please refer to definitions 토렌트이슈 조개닷컴 on page 2 of this press release and 알부민 588NET 토렌트이슈 588NET in Takeda’s financial 알부민 소리바다 statements 야한것 [i]more 토렌트이슈 AVGLE details.

[ii] 남자나체 [ii]growth compares two 알부민 periods (quarters or years) of financial results under 알부민 이헨타이 토렌트이슈 이헨타이 a common basis and is used by management to assess 토렌트이슈 엑스비디오 the business. These financial results are calculated on a 토렝이 [ii]currency basis and excluding the impact of divestitures and other 달나라티비TV [ii]토렌트이슈 미니원피스 that are 알부민 livejasmin unusual, non-recurring items or unrelated to our ongoing operations.

[iii] Underlying growth for the fiscal year ended March 31, 2020 versus the previous fiscal year ended March 31, 2019, pro-forma. The pro-forma baseline represents the sum of Takeda revenue for the 토렌트이슈 원피스형비키니 previous fiscal year (April 2018 to March 2019) plus Legacy Shire revenue from April 2018 through the acquisition date (January 8, 2019), 알부민 어깨넓은여자비키니 both adjusted to remove the revenue from divested assets, with Legacy Shire revenue converted to JPY at 알부민 the rate of 1 USD = 111 달나라티비TV [iii](average FX rate for the previous fiscal year ended March 31, 2019) and converted from US GAAP to IFRS with no material differences.

[iv] Core Operating Profit 달나라티비TV [iv]net profit adjusted to exclude 토렌트이슈 AVMANY income tax expenses, the share of profit or loss 알부민 of investments accounted for using the equity method, finance expenses and income, other operating expenses and income, amortization and impairment losses on acquired intangible assets 알부민 대구비키니라인제모 and other items unrelated to 토렌트이슈 xp폴더공유 Takeda’s core operations, such as purchase accounting effects and transaction 알부민 related costs.

[v] Underlying growth adjusts for divestitures 알부민 굿찌 (assets 알부민 빵빵넷 divested in 알부민 FY2019 and disclosed divestitures expected 토렌트이슈 스트림클럽 to close in 섹시팡 [v]and 토렌트이슈 applies a 토렌트이슈 오피걸스야동 constant exchange rate (FY2019 full GIRLS4U [v]average FX rate).

떡지도 Viewsource version 알부민 7MM on businesswire.com:Korea Newswire distributes 토렌트이슈 JAVOCADO your adultworld Viewacross every media channels through 토렌트이슈 자브프리 the 알부민 공유 토렌트이슈 공유 industry’s largest press release 알부민 별킹 distribution network

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