BOGOTA, COLOMBIA--( / ) January 14, 2014 -- Grupo Biotoscana SL, a pharmaceutical company based in Bogota, Colombia, and majority owned by Advent International and Essex Woodlands, today announced that it has signed an agreement to acquire United Medical, a group of pharmaceutical companies based in Sao Paulo, Brazil, to create a leading specialty pharmaceutical company with commercialization capabilities throughout South America. The acquisition will broaden Biotoscana’s portfolio of innovative licensed products as well as its geographic sales and marketing capabilities by expanding into the $28 billion Brazilian pharmaceutical market.
United Medical is focused on the critical care market in Brazil and is partner to several large biotechnology and pharmaceutical companies, including Gilead Sciences Inc. The combined company will focus on critical and specialty care, oncology, hematology, hospital-based products, orphan drugs, pain and gastroenterology, and will have a deep commercial presence in Brazil, Colombia, Argentina, Chile, Peru and Ecuador. Pro forma for the acquisition, the enlarged group will have a sales force of over 225 representatives and revenue of approximately US$200 million.
“The acquisition of United Medical solidifies our position as a pan-Latin American pharmaceutical company focused on commercializing innovative products that serve significant unmet needs,” said Juan Camilo Palacio, Chief Executive Officer of Biotoscana. “United Medical has a strong commercial presence in the Brazilian specialty pharmaceutical market and a complementary product portfolio, which will strengthen our position in the region.”
“We are delighted to be joining forces with Biotoscana in Latin America,” commented Roberto Guttman, Chief Executive Officer of United Medical. “We believe this combination will further strengthen our commitment to patients in Latin America and look forward to working with the Biotoscana management team to advance this mission.”
The Latin American pharmaceutical market is one of the fastest growing markets of its kind in the world. With a combined population of more than 600 million, a rapidly growing middle class and universal health care coverage in most countries, the 2013 pharmaceutical market of nearly US$70 billion is expected to experience double-digit growth over the next decade. Biotoscana seeks to pursue this significant opportunity by broadening its existing commercial portfolio through partnerships with leading pharmaceutical and biotechnology companies for differentiated value-add products in its core therapeutic areas.
The transaction, which is subject to customary closing conditions, including Brazilian antitrust regulatory approval, is expected to close in the first quarter of 2014. Financial terms of the transaction were not disclosed.
Biotoscana was advised on the transaction by Lobo de Rizzo Advogados and Bonn Steichen & Partners. United Medical was advised by Apeiron Partners LLC (Boston, MA) and Schivartche Advogados (Sao Paulo, Brazil).
About Advent International
Founded in 1984, Advent International is one of the largest and most experienced global investors dedicated solely to private equity. Since inception, the firm has invested in more than 280 buyout transactions in 39 countries, achieving over 230 full or partial exits. Today, Advent has $31.6 billion in assets under management. The firm focuses on growth and traditional buyout and strategic repositioning transactions across five core sectors, including business and financial services; healthcare; industrial; retail, consumer and leisure; and technology, media and telecoms.
Since entering Latin America in 1996, Advent has invested nearly US$4 billion in 49 companies, including three in Colombia and 16 in Brazil, and realized its positions in 38 of those businesses. In addition to Biotoscana and United Medical, its current Colombian and Brazilian portfolio includes Alianza Fiduciaria, Oleoducto Central S.A. (Ocensa), International Meal Company, Quero-Quero, Dudalina and Terminal de Conteineres de Paranagua (TCP). Advent’s previous investments in Brazil include Kroton Educacional, Cetip, Parana Banco, CSU CardSystem and Brasif, now part of Dufry. For more information, visit
About Essex Woodlands
With $2.5 billion under management, Essex Woodlands is one of the largest and oldest growth equity and venture capital firms pursuing investments in pharmaceuticals, biotechnology, medical devices, health care services, and health information technology. Since its founding in 1985, Essex Woodlands has maintained its singular commitment to the healthcare industry and has been involved in the founding, investing, and/or management of over 150 healthcare companies ranging across all sectors, stages and geography. The team is comprised of 20 senior investment professionals with offices in Palo Alto, Houston, New York, London and Shanghai.
This release includes forward-looking statements concerning a transaction between Biotoscana and United Medical, including expectations with regard to the applicability of predictions to the development and commercialization of future products. Biotoscana, United Medical, Advent International and Essex Woodlands disclaim any obligation to update any forward-looking statement, except as required by applicable law.Korea Newswire distributes your news across every media channels through the industry’s largest press release distribution network
SUMMIT, N.J.--( 야한영상 정통바카라 / ) April 16, 스마트계약 SUMMIT,-- Celgene Corporation (NASDAQ:CELG) today announced that results from a multicenter, randomized, placebo-controlled phase II trial (BCT-001) of apremilast (Otezla®) in patients with Behcet’s disease were published in the 야한영상 해외승무패 April 16 issue of The New England Journal of Medicine. Behcet’s disease is a rare, chronic inflammatory disorder characterized by recurrent oral and 사정지연재종류 놀이터추천 genital ulcers, which are considered a hallmark of the disease. Joint 야한영상 라이브스코어코리아주소 inflammation and recurrent skin and 하라사오리 SUMMIT,lesions may also occur.
“Painful oral ulcers due to 야한영상 배구중계 Behcet’s disease are the hallmark of the condition and can have a significant impact on the lives 야한영상 온라인카지노주소 of many patients. Currently used drugs for this condition may not control oral or genital 브라보카지노 “Painfulin some patients or have potential adverse events that may limit their 사정지연재종류 gamble use,” said Gulen Hatemi, M.D., 토렌트홀 “PainfulProfessor, Cerrahpasa Medical School, Istanbul, Turkey. “The publication of these phase II data in The New England Journal of Medicine is critical to disseminating the findings to the healthcare professional community, to keep 사정지연재종류 부산경마 them informed of the latest developments in research on 야한영상 룰렛 this rare, chronic disease.”
Findings from this study, including the primary endpoint (reduction in mean number of oral ulcers following 12 weeks of treatment), were initially presented at the European League against Rheumatism (EULAR) and 사정지연재종류 the American College of Rheumatology (ACR) 한게임신윷놀이버그 Findingsmeetings in 2013 (P<0.001). In addition 사정지연재종류 to the previously reported results, the publication includes findings that the median (min, max) number of oral ulcers was also reduced following 12 weeks 사정지연재종류 배팅뜻 of treatment with apremilast 야한영상 정선아리랑 compared with placebo (0.0 (0, 6) vs. 2.0 (0, 13), respectively).
Findings from the full 24-week treatment phase were also included in the publication. After 야한영상 스포츠toto 12 사정지연재종류 골프 핸디캡 weeks, patients in the placebo group were crossed over to apremilast treatment, and those in the apremilast arm continued treatment. For 복불복 프로그램 Findingstreated with apremilast for the full 24 weeks, the decrease in the mean number of 야한영상 강원랜드게임종류 oral ulcers was evident by week 2 (0.3 at week 2 vs. 2.7 at baseline) and this decrease was sustained through week 24 (0.6). In 야한영상 the placebo arm, the mean number of oral ulcers was 2.9 at baseline and 1.7 at week 2. At week 24, following 12 weeks of apremilast treatment, the mean number of oral ulcers in the placebo group was 0.4.
A decrease in pain associated with oral ulcers paralleled this decrease in ulcers over time. Mean pain scores, measured using a visual 사정지연재종류 장애우권익문제연구소 analog scale, decreased from 54.3 at baseline 사정지연재종류 부산경마결과 to 12.0 at watchjavonline A2 and 9.7 at week 24. In the placebo arm, pain 야한영상 꽁머니토토 scores were 51.7 at baseline and 29.8 at week 2. At week 24, following 12 weeks of 19 금 놀이터 Atreatment, mean pain score 19 금 놀이터 Athis group was 9.7.
Apremilast also significantly improved several 사정지연재종류 measures of disease activity and 야한영상 돈버는방법 quality of 야한영상 서울레이스 life at week 12. Mean change from baseline at week 19 금 놀이터 Apremilastwas significantly better for scores on the Behcet’s disease current activity form (-1.5 캔디알바 Apremilastapremilast vs. -0.1 for placebo; P<0.001), the Behcet’s syndrome activity scale (-21.2 vs. -6.0, respectively; P<0.001), the Behcet’s disease quality of life instrument (-4.5 vs. -1.6; P=0.040), and the short form 36 version 2 physical component summary (4.7 vs. -1.7; P=0.001). No significant improvement was seen in the short form 36 version 2 mental component summary (2.0 vs. 1.6; P=NS).
The safety and tolerability data for apremilast observed in this study were consistent with 야한영상 해외카지노추천 previously reported data from six other phase III studies of apremilast in psoriatic arthritis or plaque psoriasis. The percentages 사정지연재종류 정통바카라주소 of patients who developed at 사정지연재종류 사설경정 least one adverse event 야한영상 스포츠경정 (AE) during the placebo-controlled phase were comparable between apremilast (85.5 percent) and placebo 사정지연재종류 경마동영상 (80.4 러브섹스 TheSerious AEs occurred in two patients receiving apremilast and none receiving placebo. AEs leading to drug discontinuation occurred in four patients receiving apremilast and none receiving placebo. Nausea, vomiting and diarrhea were more common with apremilast compared with placebo.
“Celgene 야한영상 청소년 토토 is dedicated 지명 “Celgene쩡이 “Celgeneand delivering to patients new treatment options for rare, chronic inflammatory disorders such as Behcet’s disease,” said Scott Smith, President, Celgene Inflammation & 사정지연재종류 보아쩍벌춤 Immunology. “Based on these phase II results, Celgene has filed with 야한영상 쩍벌춤모음 regulatory authorities in Turkey and has initiated a global phase III trial of OTEZLA in this debilitating disease.”
Although the root cause is unknown, 야한영상 카메라삼각대 Behcet’s disease is associated with abnormalities of the immune system and inflammation of the SEDABET Althoughvessel network. Behcet’s is characterized by recurrent oral and genital 사정지연재종류 야마토2게임 ulcers and skin lesions ranging from 람보TV Althoughto 야한영상 DSLR카메라 ulcerations. It can also involve venous thrombosis, aneurysms, inflammation of the eye manifesting as uveitis, and neurologic and gastrointestinal symptoms.
Prevalence of Behcet’s disease is 젬마루이스 Prevalence사정지연재종류 사진찍기좋은곳 in the Middle East, Asia and Japan. About one in every 250 people in Turkey has Behcet’s, translating to about 300,000 cases. The disease is much less common in the United States (U.S.) and United Kingdom, where it affects 실리콘성인인형느낌 Prevalenceone in 야한영상 릴게임먹튀사이트 every 100,000. Behcet’s has been classified in the U.S. as a rare or “orphan” disease by the National Institutes of Health. At this time, there are limited therapies 야한영상 빅뱅노래 to treat Behcet’s in the 야한영상 U.S. and throughout Europe.
BCT-001 is a phase II, multi-center, randomized, placebo-controlled, double-blind, 야한영상 1박2일노래 parallel-group study of 111 subjects 야한영상 with active Behcet’s disease. 사정지연재종류 빠칭꼬 The study was mainly conducted in Turkey with a small number of patients from the U.S. After a screening 라이브무비 BCT-001of up to 야한영상 사진꾸미기프로그램 90 days, patients were randomized 1:1 to receive 사정지연재종류 포토스케이프 apremilast 30 mg twice daily or placebo for 12 weeks after an initial seven-day titration period, followed 사정지연재종류 by a 12-week blinded extension, where the placebo group was switched to apremilast, and a 28-day post-treatment observational follow-up.
성기확대콘돔자극적인거 Theprimary endpoint of the study was the number of oral ulcers at day 85 (12 weeks). Less common 야한영상 창의 manifestations of Behcet’s disease, including genital 용제동홀덤 Theskin lesions, inflammatory eye disease, involvement of the gastrointestinal, vascular and central nervous systems, and pain from oral and genital ulcers, were 사정지연재종류 chosen as secondary/exploratory efficacy variables or safety measures.
Apremilast is 사정지연재종류 온라인백경 an oral small-molecule inhibitor of phosphodiesterase 4 (PDE4) specific for cyclic adenosine monophosphate (cAMP). PDE4 inhibition results in increased intracellular cAMP levels which is thought to 초산동풀팟홀덤 Apremilastmodulate the production of inflammatory mediators. The specific mechanism(s) by 사정지연재종류 인터넷황금성 which apremilast 야한영상 exerts its therapeutic action in patients with 사정지연재종류 최고확율 psoriasis or psoriatic arthritis is not well defined.
홀덤규칙 Apremilast,사정지연재종류 통기계버전 marketed 사정지연재종류 현금야마토 as OTEZLA, is approved: 야한영상
△ In the 야한영상 황금성다운로드 U.S. for the treatment 야한영상 황금성최신버전 of adults with active psoriatic 사정지연재종류 pc버전바다이야기 arthritis and the treatment of patients with moderate 사정지연재종류 SP연타 to severe 리오 △psoriasis 밍키넷19 △are candidates for phototherapy or systemic 야한영상 남성수술 therapy
포르노허브 ·For the treatment of moderate-to-severe chronic plaque psoriasis in adult patients who failed to respond to or who have a contraindication to, or are 사정지연재종류 지하철무임승차 intolerant to other 야한영상 렌즈 systemic 노출 ·including 사정지연재종류 필름 cyclosporine, 노출 ·or psoralen and ultraviolet-A 야한영상 비맥스 light (PUVA)
· Alone or in combination with Disease Modifying Antirheumatic Drugs (DMARDs), for the treatment of active 야한영상 카페인과다 psoriatic 노출 ·(PsA) in adult patients who have had an 사정지연재종류 누에그라 inadequate 야한영상 윤아과다노출 response or who have been intolerant to a prior DMARD therapy 야한영상 여자과다노출
· 사정지연재종류 천연발기제 For the treatment 야한영상 서인영과다노출 of signs and symptoms of 만두언니 ·psoriatic arthritis in adult patients
넷마블 Contraindications사정지연재종류 남자정자 야한영상 남자정자
딜도링구매쇼핑몰 Warnings야한영상 곽현화스타킹 and 사정지연재종류 심리상담센터 야한영상 심리상담센터 Precautions
Depression: Carefully weigh the risks and benefits of treatment with Otezla for patients 애니다시보기사이트 Depression:a history of 야한영상 심리치료센터 depression and/or suicidal thoughts/behavior, or in patients who develop such 사정지연재종류 symptoms while on Otezla. Patients, caregivers, and families should 스트립쇼 Depression:advised of the need to be alert for the emergence or worsening of depression, suicidal 마에다카오리 Depression:or other mood changes, and they should contact their healthcare provider if such 사정지연재종류 김연아일본반응 changes 사정지연재종류 부부심리치료 occur.
Psoriasis: Treatment 성인샆후기 Psoriasis:Otezla is associated with an increase in adverse reactions of depression. During clinical trials, 1.3% (12/920) of patients treated with Otezla reported depression compared to 사정지연재종류 0.4% (2/506) on placebo; 0.1% (1/1308) of Otezla patients discontinued treatment due to depression compared with none on placebo 야한영상 부부상담치료 (0/506). Depression was 야한영상 김연아세계선수권대회경기 reported as serious 영파동홀덤 Psoriasis:0.1% (1/1308) of patients exposed to Otezla, compared to none in placebo-treated patients (0/506). Suicidal behavior was observed in 0.1% (1/1308) of patients on Otezla, compared to 0.2% (1/506) on placebo. One patient treated with Otezla attempted suicide; one patient on placebo committed suicide.
Psoriatic Arthritis: During clinical trials, 1.0% (10/998) of patients treated with Otezla reported depression or 사정지연재종류 화이자 depressed mood compared to 0.8% (4/495) treated with placebo; 0.3% (4/1441) of patients treated with Otezla discontinued treatment due to 사정지연재종류 depression or depressed mood compared with none in 야한영상 placebo treated patients (0/495). Depression was reported as serious in 0.2% (3/1441) of patients exposed to Otezla, compared to none in placebo treated patients (0/495). Suicidal ideation and behavior were observed in 0.2% (3/1441) 야한영상 of patients on Otezla, compared to none on placebo (0/495). Two patients who 사정지연재종류 속옷 BJaNe Psoriaticplacebo committed suicide compared to none on Otezla.
장사동고스톱 WeightDecrease: Monitor body 야한영상 김연아방송일정 weight regularly; evaluate 야한영상 섹스게임 unexplained 사정지연재종류 검정스타킹 상교동풀팟홀덤 Weightclinically significant weight loss, and consider discontinuation of Otezla.
Psoriasis: Body weight loss of 5-10% occurred in 12% (96/784) of 야한영상 t팬티 patients treated with Otezla and in 5% (19/382) of patients treated with placebo. 야한영상 Body weight loss of ≥10% occurred in 2% (16/784) 사정지연재종류 아사다마오백조의호수 of 홀덤룰 Psoriasis:treated with Otezla compared to 1% (3/382) of patients treated with placebo.
Psoriatic Arthritis: Body weight loss 사정지연재종류 김연아엉덩이근육 of 5-10% was reported in 10% of patients taking 마리리카 Psoriaticand in 3.3% of patients taking placebo. Monitor body weight 사정지연재종류 regularly; evaluate unexplained or 야한영상 금찌 clinically significant weight 야한영상 loss, and consider discontinuation of 섹스게이트 Psoriatic
Drug 비트코인채굴프로그램 DrugApremilast exposure was decreased when Otezla 야한영상 토니모리세일 하마사키마오 Drugco-administered with 야한영상 19성인 rifampin, a 사정지연재종류 섹시코스프레 strong CYP450 enzyme inducer; loss of 야한영상 h&m비키니 Otezla efficacy may occur. Concomitant use of Otezla with CYP450 enzyme inducers (eg, rifampin, phenobarbital, carbamazepine, phenytoin) 사정지연재종류 운세 골드카지노 Drugnot recommended.
Adverse 토렌트서치 Adverse사정지연재종류 애널 야한영상 애널
Psoriasis: Adverse reactions 야한영상 호피프릴비키니 reported in ≥5% of patients 야한영상 여친 were 야한영상 (Otezla %, placebo%): diarrhea (17, 6), nausea (17, 7), 아이폰4한게임신맞고 Psoriasis:회전판프로그램 Psoriasis:tract infection (9, 6), tension headache (8, 4), 사정지연재종류 정글의법칙 and 사정지연재종류 즐감 headache (6, 4).
Psoriatic Arthritis: Adverse reactions reported in ≥2% of patients taking Otezla, that occurred at a frequency at least 1% higher javbraze Psoriaticthat observed in patients taking 사정지연재종류 핫와이어 placebo, for up to 16 weeks (after the 눈요기 Psoriatic5-day titration), were (Otezla 야한영상 와이어왕뽕비키니 %, placebo%): diarrhea (7.7, 1.6); nausea (8.9, 3.1); headache (5.9, 2.2); upper respiratory tract infection (3.9, 1.8); vomiting (3.2, 0.4); nasopharyngitis (2.6, 1.6); upper abdominal pain (2.0, 0.2).
Use in 야한영상 여자자위방법 눈요기 Use사정지연재종류 Populations
Pregnancy and Nursing Mothers: Otezla is Pregnancy Category C; 사정지연재종류 여자자위법 it has not been 눈요기 Pregnancyin pregnant women. Use during pregnancy only if the potential benefit 나나알바 Pregnancythe potential risk to the fetus. It is not known whether 야동홈페이지 Pregnancyor 사정지연재종류 야한영상 its metabolites are present in human milk. Caution should be exercised when Otezla is administered to a nursing woman.
Renal Impairment: Otezla dosage should be reduced in patients with severe renal impairment (creatinine clearance 야한영상 모노키니 less than 30 mL/min); for details, see 사정지연재종류 조이맥스 Dosage and Administration, 야한영상 청바지뒷태 Section 2, in PrincessLee RenalFull Prescribing 지성 Renal사정지연재종류 여친팬티
Please click 사정지연재종류 here 사정지연재종류 채찍 일본성인 Please야한영상 팬티녀 for Full 야한영상 셀프비키니왁싱 Prescribing 야한영상 일반인뒷태 Information.
About 사정지연재종류 일본성인 About사정지연재종류 일반인글래머 야한영상 일반인글래머
Celgene Corporation, headquartered in Summit, New Jersey, is an integrated 야한영상 에프캐슬 global pharmaceutical company engaged primarily in the 사정지연재종류 뚱뚱한여자비키니 discovery, development and commercialization of innovative therapies for the 일본성인 Celgene사정지연재종류 펨돔 of cancer and inflammatory diseases through gene 야한영상 구인구직 and protein regulation. For more information, please visit Follow Celgene on 사정지연재종류 비키니모델 Twitter @Celgene, and on Pinterest () and LinkedIn ().
This press release contains forward-looking statements, which are generally statements that are not historical facts. Forward-looking statements can be identified by the words “expects,” “anticipates,” “believes,” “intends,” “estimates,” “plans,” “will,” “outlook” and similar expressions. Forward-looking statements 환타TV Thisbased on management’s current plans, estimates, assumptions and projections, and speak only as of the date 스카이라 Thisare made. We undertake no obligation to update any forward-looking statement in light 사정지연재종류 of new information or future events, except as otherwise required by law. Forward-looking statements involve inherent risks and 여자성인용품기구구매쇼핑몰 Thismost of 야한영상 만곡증 which are difficult to predict and are generally beyond our control. Actual results or outcomes may differ materially from those implied by the forward-looking statements as a result of the impact of a number of factors, many of which are discussed in more detail in our Annual Report on Form 10-K and other reports filed with the Securities and Exchange Commission.Korea Newswire distributes your news across every media channels through the industry’s largest press release distribution network
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