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CAMBRIDGE, MASS. & OSAKA, JAPAN--( / ) June 15, 2020 -- Takeda Pharmaceutical Company Limited (TSE:4502/NYSE:TAK) (“Takeda”) today announced it will orally present the results of two studies at the 25th Congress of the European Hematology Association (EHA). Presentations are available online starting Friday, June 12, 2020, and include positive results from TOURMALINE-MM4, a Phase 3, randomized clinical trial evaluating the effect of single-agent oral NINLARO™ (ixazomib) as a first-line maintenance therapy in adult patients diagnosed with multiple myeloma who had not been treated with stem cell transplantation. Takeda is also presenting key insights from the US MM-6 trial, which investigates the effectiveness and safety of an in-class transition to oral NINLARO in combination with lenalidomide and dexamethasone in newly diagnosed multiple myeloma patients who have previously received a parenteral bortezomib-based triplet induction therapy.

The TOURMALINE-MM4 trial achieved its primary endpoint, with treatment with NINLARO resulting in a statistically significant and clinically meaningful improvement in progression-free survival (PFS) versus placebo in adult patients diagnosed with multiple myeloma not treated with stem cell transplantation (hazard ratio [HR] 0.659; CI: 95; p <0.001). This corresponds to a 34% reduction in risk of progression or death in patients treated with NINLARO. The safety profile of NINLARO was consistent with previously reported results of single-agent NINLARO use and there were no new safety signals identified.

“There is a strong need for additional maintenance treatments for multiple myeloma, where currently approved options are limited,” said Meletios Dimopoulos, MD, University of Athens School of Medicine and principal investigator of the TOURMALINE-MM4 trial. “Data from this Phase 3 clinical trial reinforce the role of proteasome inhibition as a maintenance therapy and suggest that longer duration of therapy can improve a response, in addition to extending it. These data could be highly impactful for those who currently have limited options, which is often the case with patients not eligible for a stem cell transplant.”

Key findings of the TOURMALINE-MM4 trial, to be presented by Dr. Dimopoulos include:

· The trial achieved its primary endpoint, with treatment with NINLARO resulting in a statistically significant and clinically meaningful improvement in PFS in adult patients diagnosed with multiple myeloma not treated with stem cell transplantation (hazard ratio [HR] 0.659; CI: 95; p <0.001). Median PFS for patients in the NINLARO arm was 17.4 months compared to 9.4 months in the placebo arm. This corresponds to a 34.1% reduction in risk of progression or death in patients treated with NINLARO.

· The secondary endpoint of overall survival (OS) is not yet mature and follow-up is ongoing.

· The benefits of NINLARO maintenance were realized in the context of a well-tolerated safety profile and no adverse impact on patients’ quality of life.

· The safety profile of NINLARO is consistent with previously reported results of single-agent NINLARO use and there were no new safety signals identified.

- The most common treatment emergent adverse events (TEAEs) (with incidence ≥5% higher with ixazomib) were nausea, vomiting, diarrhea, rash, peripheral neuropathy (PN) and pyrexia.

- Grade ≥3 TEAEs were experienced by 36.6% of patients receiving NINLARO versus 23.2% receiving placebo.

- The rate of new primary malignancies was 5.2% versus 6.2% in the placebo arm.

- Discontinuation of treatment due to TEAEs was low, at 12.9% in the NINLARO arm and 8% in the placebo arm.

- The rate of on-study deaths was 2.6% in the NINLARO arm compared to 2.2% in the placebo arm.

Updated data from US MM-6 will also be presented orally at EHA. The trial revealed the in-class transition from treatment with parenteral bortezomib to a NINLARO-based treatment, taken by patients at home, allowed for prolonged proteasome inhibitor administration and resulted in an increase in overall response rate from 62% to 70% and an increase in complete response from 4% to 26%. These data suggest promising efficacy without impacting patients’ quality of life. The safety profile of NINLARO treatment in this setting is favorable with no unexpected safety signals identified in US MM-6.

“The positive data from the Phase 3 trial evaluating NINLARO as a maintenance therapy in patients not eligible for stem cell transplantation showed significant improvement in progression-free survival,” said Christopher Arendt, Head, Oncology Therapeutic Area Unit, Takeda. “Coupled with the US MM-6 trial results of in-class transition from parenteral to oral proteasome inhibitor, these data add to the body of evidence supporting NINLARO could be an effective, tolerable and convenient medicine for patients with multiple myeloma that allows for an increased duration of treatment with proteasome inhibitors resulting in better outcomes.”

NINLARO is currently approved in combination with lenalidomide and dexamethasone for the treatment of patients with relapsed / refractory multiple myeloma in more than 65 countries.

About the TOURMALINE-MM4 Trial

TOURMALINE-MM4 is a randomized, placebo-controlled, double-blind Phase 3 study of 706 patients, designed to determine the effect of single-agent oral NINLARO™ (ixazomib) maintenance therapy on progression-free survival (PFS), compared to placebo, in adult patients newly diagnosed with multiple myeloma not treated with stem cell transplant, who have completed 6-12 months of initial therapy and achieved a partial response or better. For additional information, please visit

About the US MM-6 Trial

US MM-6 is an ongoing open-label, single-arm, multicenter study evaluating the effectiveness and safety of an in-class transition to NINLARO™ (ixazomib) in combination with lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma who received bortezomib-based triplet induction. The primary endpoint is progression-free survival (PFS). Key secondary endpoints include duration of therapy and duration of response. For additional information:

About Multiple Myeloma

Multiple myeloma is a life-threatening rare blood cancer that arises from the plasma cells, a type of white blood cell that is made in the bone marrow. These plasma cells become abnormal, multiply and release a type of antibody known as a paraprotein, which causes symptoms of the disease, including bone pain, frequent or recurring infections and fatigue, a symptom of anemia. These malignant plasma cells have the potential to affect many bones in the body and can cause a number of serious health problems affecting the bones, immune system, kidneys and red blood cell count. The typical multiple myeloma disease course includes periods of symptomatic myeloma followed by periods of remission. Nearly 230,000 people around the world live with multiple myeloma, with approximately 114,000 new cases diagnosed globally each year.

About NINLARO™ (ixazomib) capsules

NINLARO™ (ixazomib) is an oral proteasome inhibitor which is being studied across the continuum of multiple myeloma treatment settings. NINLARO was first approved by the U.S. Food and Drug Administration (FDA) in November 2015 and is indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy. NINLARO is currently approved in more than 65 countries, including the United States, Japan and in the European Union, with more than 10 regulatory filings currently under review. It was the first oral proteasome inhibitor to enter Phase 3 clinical trials and to receive approval.



Thrombocytopenia has been reported with NINLARO (28% vs. 14% in the NINLARO and placebo regimens, respectively) with platelet nadirs typically occurring between Days 14-21 of each 28-day cycle and recovery to baseline by the start of the next cycle. It did not result in an increase in hemorrhagic events or platelet transfusions. Monitor platelet counts at least monthly during treatment with NINLARO and consider more frequent monitoring during the first three cycles. Manage with dose modifications and platelet transfusions as per standard medical guidelines.

Gastrointestinal toxicities have been reported in the NINLARO and placebo regimens respectively, such as diarrhea (42% vs. 36%), constipation (34% vs. 25%), nausea (26% vs. 21%), and vomiting (22% vs. 11%), occasionally requiring use of antiemetic and anti-diarrheal medications, and supportive care.

Peripheral neuropathy was reported with NINLARO (28% vs. 21% in the NINLARO and placebo regimens, respectively). The most commonly reported reaction was peripheral sensory neuropathy (19% and 14% in the NINLARO and placebo regimens, respectively). Peripheral motor neuropathy was not commonly reported in either regimen (< 1%). Monitor patients for symptoms of peripheral neuropathy and adjust dosing as needed.

Peripheral edema was reported with NINLARO (25% vs. 18% in the NINLARO and placebo regimens, respectively). Evaluate patients for underlying causes and provide supportive care, as necessary. Adjust the dose of dexamethasone per its prescribing information or the dose of NINLARO for severe symptoms

Cutaneous reactions occurred in 19% of patients in the NINLARO regimen compared to 11% of patients in the placebo regimen. The most common type of rash reported in both regimens was maculo-papular and macular rash. Manage rash with supportive care, dose modification or discontinuation.

Thrombotic microangiopathy, sometimes fatal, including thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS), have been reported in patients who received NINLARO. Monitor for signs and symptoms of TPP/HUS and stop NINLARO if diagnosis is suspected. If the diagnosis of TPP/HUS is excluded, consider restarting NINLARO. The safety of reinitiating NINLARO therapy in patients previously experiencing TPP/HUS is not known.

Hepatotoxicity, drug-induced liver injury, hepatocellular injury, hepatic steatosis, and hepatitis cholestatic have been uncommonly reported with NINLARO. Monitor hepatic enzymes regularly and adjust dose for Grade 3 or 4 symptoms.

Pregnancy- NINLARO can cause fetal harm. Advise male and female patients of reproductive potential to use contraceptive measures during treatment and for an additional 90 days after the final dose of NINLARO. Women of childbearing potential should avoid becoming pregnant while taking NINLARO due to potential hazard to the fetus. Women using hormonal contraceptives should use an additional barrier method of contraception.

Lactation- It is not known whether NINLARO or its metabolites are excreted in human milk. There could be potential adverse events in nursing infants and therefore breastfeeding should be discontinued.


Hepatic Impairment: Reduce the NINLARO starting dose to 3 mg in patients with moderate or severe hepatic impairment.

Renal Impairment: Reduce the NINLARO starting dose to 3 mg in patients with severe renal impairment or end-stage renal disease (ESRD) requiring dialysis. NINLARO is not dialyzable and, therefore, can be administered without regard to the timing of dialysis.


Co-administration of strong CYP3A inducers with NINLARO is not recommended.


The most frequently reported adverse reactions (≥ 20%) in the NINLARO regimen, and greater than in the placebo regimen, were diarrhea (42% vs. 36%), constipation (34% vs. 25%), thrombocytopenia (28% vs. 14%), peripheral neuropathy (28% vs. 21%), nausea (26% vs. 21%), peripheral edema (25% vs. 18%), vomiting (22% vs. 11%), and back pain (21% vs. 16%). Serious adverse reactions reported in ≥ 2% of patients included thrombocytopenia (2%) and diarrhea (2%). For each adverse reaction, one or more of the three drugs was discontinued in ≤ 1% of patients in the NINLARO regimen.

For European Union Summary of Product Characteristics:

For US Prescribing Information:

For Canada Product Monograph:

Takeda’s Commitment to Oncology

Our core R&D mission is to deliver novel medicines to patients with cancer worldwide through our commitment to science, breakthrough innovation and passion for improving the lives of patients. Whether it’s with our hematology therapies, our robust pipeline, or solid tumor medicines, we aim to stay both innovative and competitive to bring patients the treatments they need. For more information, visit

About Takeda Pharmaceutical Company Limited

Takeda Pharmaceutical Company Limited (TSE:4502/NYSE:TAK) is a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, committed to bringing Better Health and a Brighter Future to patients by translating science into highly-innovative medicines. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Rare Diseases, Neuroscience, and Gastroenterology (GI). We also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. We are focusing on developing highly innovative medicines that contribute to making a difference in people's lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline. Our employees are committed to improving quality of life for patients and to working with our partners in health care in approximately 80 countries.

For more information, visit

Important Notice

For the purposes of this notice, “press release” means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited (“Takeda”) regarding this release. This press release (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this press release. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This press release is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws.

The companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, “Takeda” is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.

Forward-Looking Statements

This press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda’s future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”, “aims”, “intends”, “ensures”, “will”, “may”, “should”, “would”, “could” “anticipates”, “estimates”, “projects” or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda’s global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations; the success of or failure of product development programs; decisions of regulatory authorities and the timing thereof; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic, on Takeda and its customers and suppliers, including foreign governments in countries in which Takeda operates, or on other facets of its business; the timing and impact of post-merger integration efforts with acquired companies; the ability to divest assets that are not core to Takeda’s operations and the timing of any such divestment(s); and other factors identified in Takeda’s most recent Annual Report on Form 20-F and Takeda’s other reports filed with the U.S. Securities and Exchange Commission, available on Takeda’s website at: or at Takeda does not undertake to update any of the forward-looking statements contained in this press release or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this press release may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda’s future results.

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골뱅이 드라콜라 Ituano(SP) 유망주식추천 레인보우움짤 토토복권하는방법 성인만화사이트 둔산동퍼블릭룸 싸이월드예쁜사진 동문동노래방 고지전 7번방의선물 여자나체 가남읍노래방 내마들황정음머리 freeporn 김령하 월평동안마 야관문부작용 인피니티jx 광주방석집 MATCHING 음식상자 박민영소주광고 엣지님 삼각산동룸싸롱 작성자 코코메디효과 지압봉 카라판도라노출 비비바카라 롱투블럭컷 화지동노래방 신교동토킹bar 철산동오피 조민서화보 통인동가라오케 65g컵현재 차대왕 소리넷주소찾기 동부하이텍주식 태연고영욱 노름닷컴 옥주현 대구타투잘하는곳 유로파 목욕탕셀카 연금복권당첨확인 장편야오이만화 스티바에이 2013신인걸그룹 프로토타입2 90년대가요계 CSKA소피아 나나알바 개인연금펀드 쇼핑몰성인인형체험 물밤 가평리얼돌성인인형 일직동퍼블릭룸 야동다운받는곳 로또1등비결 비키니사진섹시화보 일본누드 케냐둘리순정동심톡 UCL 밤포유 iplol 신화실업주식 신도림동리얼돌성인인형 예쁜속옷브랜드 남산동나이트 메이플스토리이쁜머리 연예인화보 사기소동출장마사지 야왕 가슴꼭지노출 PENPAL 오학동토킹bar 해피투게더이지애 효린d컵 유노윤호덜렁 북면키스방 성인영화종류 JAV베드트위터 권지용엉덩이춤 야동매니아 숭인동성인인형체험 논현동건마 성성동풀싸롱 스포츠토토 샴페인써니노출 이유신용재 온라인미술관 아이유엉덩이노출 일반인h컵 원천동건마 리춘희 원주활마루해장국 코스피야간선물 논현동룸싸롱 싱글파파는열애중 섹시봉봉250화 신길동토킹bar 이율좋은적금 오예스알바 소녀시대igotaboy직캠 FREEXXX 단기추천종목 주식투자관리 머리큰남자헤어스타일 도원동토킹bar 섹시글래머 overnet 대방동토킹bar 복권통계 헌팅 야동영화 과학자 노원구가라오케 DITJF 최신한국영화추천 신화vs신창플레이어 리포터조민서 페티쉬동영상 화양동성인게임장 카페베네기프트카드 코끼리TV 유지연성형전 섹시교복 고니카지노주소 미아동안마 해운대비키니녀 용곡동리얼돌성인인형 박효신먼곳에서 천성동대딸방 콘돔회사 인터넷증권거래 명품썬그라스수리 핫독티비 553회로또자동번호 토토배당금 두구동유흥주점 게임불카누스 PERD1 투니모아 관촉동출장마사지 수지합성노출 플레이엔젤스 야생화자수 경상북도떡집 엑셀매매일지 전현무아버지 소라스포 마나모아구 주식스탁킹 반경수 득산동유흥거리 셀카야한동영상 홍지민 색스 에프엑스핫섬머 보수동유흥문화 삼동토킹bar 섹스경험담 신사동건마 브아걸가인 하왕십리동립카페 섹시천국 영성동대딸방 토지소액투자 빅예스 태양광테마 동영상편집기 소라넷새로운 mgm 샌즈카지노 증권대박 칼라성인만화 대성동나이트 18금 맨땅에헤딩키스신 김포출장마사지 방학동성인게임장 야당동오피 여성성기구조 심인성발기부전치료 지숙몸매 황훈 여관바리여관바리 섹시녀 뮤직뱅크태연표정 천왕동룸싸롱 정력에좋은운동 코엑스 한강수상택시 위대한만남 후기나이트 카버젝트 Jerv 선물옵션만기일이란 성남노래빠 산직동퍼블릭룸 비트스눕 지사모집 GS리테일주식 동면룸싸롱 이건산업주식 전쟁드라마 우결한선화 남자아이돌사진 정재호 웅천읍떡집 수안동토킹bar 도봉동안마 무료로또번호 나현 낙민동가라오케 일본여자친구 여자나체사진 칵스타정품구별법 드림하이옥택연신발 네토닷컴서양야동 김현주아나운서 제시카궁금타 색스69 19만화 군자동토킹bar 알보칠 섹시한비키니수영복 남자누드만화 soraruorg 명장동건마 미즈나레이 마두동건마 브래지어노출 US증권연구소 올맨접속 김혜수비키니 권지용양요섭 시크릿talkthat 삐삐토렌트 성고민 일러스트이미지 코인거래소 누두 야한코리아 색스포유 라이브홀덤 가양동방석집 귀여운여자이름 오나왕 황찬성 구평동오피 김지연노출 서우인교진 육덕진동영상 검산동유흥문화 진진 음모모낭염 강남룸카페 가수배우 야한여자사진 ADULT 강혜지 베스트썰 현암동풀싸롱 소리엘 연예인엑스파일3 강현수해외선물 설리다리굵기 제이통찌찌뽕여자 천동유흥거리 음악순위 박해미 스포츠멀티샵 구의동건마 반월동키스방 운양동오피 던독FC sm콘서트천상지희 광교동나이트 딸자닷컴주소찾기 독산동유흥문화 영화배경지식 GoslarerSC 겟잇뷰티속옷 박예쁜인정 재테크부업 영통대딸방 바구리 릴레스톰 야설관 색스성인 윤하쌍둥이코러스 의정부가라오케 뮤직뱅크한그루myboy 강신단 류승룡 장림동가라오케 수지리얼돌성인인형 국채현물 광안동떡집 항문검사 신교동유흥주점 bacarat 전자도서관 와이고수 정릉4동홀덤룰 황등면카지노펍 성폭행아이돌 행구동포커고수 감천동떡집 신당동유흥문화 신규고객이벤트 내손동나이트 경운동인싸포커 양전동홀덤족보 주암동풀싸롱 주택증여 중노송동오마하홀덤 금상동성인게임장 내일추천주 picasa 누상동텍사스홀덤 박봄허벅지운동 연애인x파일4 야한영화사이트 가희근황 gta4웃긴동영상 비응도동인싸포커 반곡관설동포커고수 고봉석 여교사중학생 개금동유흥주점 주식독학 먹튀가드 젖꼭직노출 삼기면성인오락실 멀티프리 가슴확대술 헤르메스가방집시백 신사우동포커고수 삼정동토킹bar 인동오마하홀덤 청호동홀덤카페 윤아합성 오픈색스 동선동5가홀덤룰 밤문화가이드 보수동룸싸롱 황금성다운로드 학동텍사스홀덤 영천동홀덤바 우리결혼했어요황정음 주식고수들의모임 셋팅파마 비너스마더피아 동선동3가텍사스홀덤 아이유달빛바다 이화동성인오락실 양평동홀덤룰 신동희 창전동방석집 비아그라조루 주현동텍사스홀덤 불사무적오마르 청춘한의원신효쾌청산 연애인미성년자성매매 옥산면오마하홀덤 이성화 영화동텍사스홀덤 Av야 게이특징 거제동유흥주점 연양동홀덤펍 범천동성인게임장 ok뱅 안양시만안구홀덤카페 개포동포커고수 오학동포커고수 반포동리얼돌성인인형 MAX1004.KR 울산룸 천안재직자 중구방석집 1xbet 귀여운10대비키니 남자친구동영상이벤트 아발론온라인라이나 먹중소 고천동키스방 십정동가라오케 비키니라인왁싱 구찌남자신발 법동아로마마사지 주천면카지노펍 섹스추천 노들강변 중앙로홀덤바 번동홀덤바 뮤직뱅크송중기 청담동성인인형체험 판암동키스방 막계동립카페 폼나고 금촌동홀덤펍 entertains 거유 구암동홀덤펍 짬보 내장동성인오락실 불당동북창pr 몸짱배경화면 수지유흥거리 페어퍼코리아주식 휴지 문희준i 양상동인싸포커 크리스브라운 교북동홀덤족보 섹시슬립 양현동성인오락실 토캅스 무료주식알박기방송 걸스데이민아단발 광주불교방송 주생면포커고수 부트토렌트 신화인터텍주식 서신동오마하홀덤 소학동성인게임장 금사동키스방 내가쓴글 맨스닷컴 브란젤리나 7M라이브스코어 애프터스쿨주연키 19만화 설사하는이유 황지동성인게임장 로열나이츠 야마토확율 양평홀덤족보 하중동인싸포커 네이버통합검색화면 수송동인싸포커 신호동성인인형체험 통인동레깅스룸 슈넬생명과학주식 비스트복근 원남동성인게임장 오산포커고수 토렌트스카이넷 동탄홀덤펍 슬픈노래 마이비누 눌차동풀싸롱 광주룸 10대속옷쇼핑몰 비스트윤두준 피에스텍주식 중리동룸싸롱 개봉3동포커고수 북구아로마마사지 구룡동인싸포커 원리 돌싱닷컴 야동다운받는곳 남구성인게임장 신세경글래머 신길4동모바일홀덤 쩍벌여 지하철게이 월곡2동인싸포커 도장동오마하홀덤 화성홀덤펍 손연재가방 상면성인게임장 구로2동홀덤룰 천송동홀덤대회 목욕의신영화캐스팅 용곡동건마 쇼밤 신공덕동북창pr 분당홀덤대회 안락동풀싸롱 중국가수 써니비율 강남동홀덤룰 마두동인싸포커 상월곡동오마하홀덤 미로면포커고수 명륜2가텍사스홀덤 송파구립카페 동광동방석집 비천동홀덤바 일베아이유합성 19금영화 삼수동홀덤바 어양동홀덤펍 유리명왕 화성인가슴커지는운동 비너스스윗핏 증권가찌라시한가인 명륜동모바일홀덤 조종면레깅스룸 괴란동성인게임장 이다해스타화보 화곡4동인싸포커 강북구나이트 동작동오마하홀덤 작전출장마사지│갈산출장마사지│동수출장마사지 tube8 대치4동홀덤족보 조촌동홀덤펍 한국d컵 15살중학생 이성민움짤 가정동토킹bar 수원비키니라인제모 성인방송무료보기 조현영계란말이 하계2동홀덤대회 암사동홀덤족보 속달동유흥주점 서노송동텍사스홀덤 상왕동노래방 일문공 에스맥주식 이승기팔근육 장척동리얼돌성인인형 산동면포커고수 대구교통방송 아야세하루카 대전동성인오락실 장척동풀싸롱 아미동안마 신흑동방석집 창성동카지노펍 태장동포커고수 청평면떡집 남자발리벨트 붕가붕가 건축학개론 노래많은블로그 만경읍홀덤룰 19자료 고깃집허리 x의계수 성인무료 문원동포커고수 성인방송배우 남자속옷세트 고사동홀덤카페 마의노출 2013년한국영화순위 아이유백팩 쩡이 명장동유흥문화 효동방석집 레이싱걸팬티노출 시흥카지노펍 백현움짤 오천면성인인형체험 중리동텍사스홀덤 북구키스방 간미연나는펫 에이브릴라빈whatthehell 진산동모바일홀덤 효자동텍사스홀덤 효자동텍사스홀덤 한승연비키니 프로토결과 티아라은정 구암동모바일홀덤 팽창형보형물수술 석림동출장마사지 웃긴지식 흥남동성인오락실 아이비닉쿤 범전동유흥거리 궁촌동레깅스룸 최은정아프리카 읍내동출장마사지 상동성인오락실 세바퀴조권 여친이랑할말없을때 포르노허브 북가좌1동카지노펍 강하면유흥주점 여자옷벋기기게임 송내동건마 김연아세계선수권일정프리 아이유beautifuldancer 북구룸싸롱 창신1동성인게임장 팔곡동토킹bar 신흥동모바일홀덤 장명동포커고수 하월곡동키스방 오천면리얼돌성인인형 신흥동오마하홀덤 자브버스 율정동홀덤바 칠산동풀싸롱 상계10동성인오락실 성산동모바일홀덤 노원구가라오케 박상민눈물잔 매룡동성인인형체험 개정면홀덤대회 TIGERLG그룹+주식 맥금동토킹bar 동내면홀덤족보 신기면홀덤대회 개미지킴이의시황투자클럽 유리가면 장기본동유흥문화 북가좌동오마하홀덤 대박주식 화산동건마 대현동성인게임장 다리찢기잘하는법 교남동홀덤대회 리한나rightnow 명일동홀덤족보 북변동방석집 원시동성인인형체험 백학면가라오케 남자친구스킨쉽 시티헌터16회 에블토토 경마 부부교환 면목동노래방 야스타 장림동노래방 신천유흥 매화동리얼돌성인인형 글래머100단pc방 폴로남자수영복 아프리카셀리 감곡면홀덤카페 수내동나이트 이다해고향 여의동홀덤대회 7MM 동선동1가홀덤펍 하계동모바일홀덤 시크릿토이 아프리카TV박가린1000일... 이서현노출 지연섹시러브 엔디보이 명륜동모바일홀덤 대정동건마 교정녀 북아현동성인게임장 성폭행 가수이은미사망 최현정 인기트로트가수 크리스티나아길레라 인터넷으로주식하기 임부요일팬티 드림하이아이유 성인나라 수트 보라씨스타 섹시하게 미술품투자 정선강원랜드 십덕후화성인 신흥동유흥문화 영주동풀싸롱 스포츠토토 18모아4주소변경 란제리녀 한국여자농구 순천선비촌 파이즈리 레이스탑 주식투자강연회 사파이어테크놀로지주식 루이비통지갑멀티 3대여신 비비안웨스트우드지갑 삼전동성인용품 먹튀폴리스믿을만 에이플러스카지노사이트 광흥창출장마사지 솔비동영상유출 귀여운여자연예인 SyrianskaFC 안산부업 폰허브새주소 애프터스쿨디바 걸스토리해체 와우패스파생상품 딸북스접속 원촌동레깅스룸 성정동유흥주점 우결동방신기 성인인터넷방송국 토토검증커뮤니티 안전한놀이터찾는법 낭월동안마 pornhat우회 김수현마린보이 화명동성인게임장 광장동오피 빅사이즈와이어비키니 직장인주말투잡 우암동풀싸롱 내발산동안마 테일즈런너카라엉덩이춤 청당동대딸방 극장판만화책 여성전용클럽 성성동성인게임장 신사동 신인아이돌루머 아이유고화질직캠 부평아로마마사지 지나꺼져줄게잘살아반복재생 남포동풀싸롱 현아흐트러지지마 로또리치골드회원 웅진동유흥주점 죽림동아로마마사지 매화동건마 오스트레일리아지도 이성민성형 사설먹튀검증 어룡동토킹bar 탄현출장마사지│풍산출장마사지│백마출장마사지 인기릴께임사이트 BET365 면세점콘돔 정품시알리스가격 봉양동성인인형체험 슈어맨삽니다 우리바다이야기 팔팔정복용방법 마이넷플러스 장원준성적 은평구나이트 최신릴깸 파워볼먹튀검증 백야행이민정 차티스 cartoonsex 충전유압압착기 노고산동아로마마사지 섹스마스터 타카오카소우스케 대격변흑마 박진영이기광 고잔동풀싸롱 야구랭킹결과 ZMFFJQ5678 네이버웹툰노출 dhfkftprtm 슈어맨같은곳 송중기이상형 홍프로 레인보우레전드영상 619당첨번호 로또575 롤챔스 통열량계 알바천사 장티푸스 석교동성인용품 19코리안성인 성생활 4tube일본야동 토지시세 슈어맨2미스터그린 세상에서제일재미있는게임 주식무료사이트 임포섹스 천사캠 부킹걸 성인무료채팅방 누나성기 루이비통지갑멀티 공짜야한소설보기 KT뮤직주식 vocal 소셜아이콘 2ne1안무 갤럭시아컴즈주식 사설먹튀검증 정가은구설수 이녹스주식 용운동건마 효자손제작 컴투스주식 칠산동성인용품 어플주식 온라인바카라사이트주소 생리기간 지나짱 15분사이즈업운동 북한전쟁선포이유 꽁서치 증거금40% 메이저놀이터순위 비스트백신봉 한성주 일본아이돌한국아이돌 아이유핫팬츠 검상동성인인형체험 양요섭지연피구 스피카독하게 한국섹스 시크릿전효성출렁 네이버화살표돌리기 슈어맨2승부 봉산동토킹bar 샴푸나이트 원피스675화번역 놀이터홍보사이트 연예인영어이름 편자 끌로에장지갑 동영상자르기 일반인길거리노출 일산가물치 가수이은미사망 룰렛게임방법 투자클럽 575회차로또 비키니옷장꾸미기 빅뱅궁금타 정용화김종현 이상급등종목 펀드이동제 한대앞공용주차장요금 누드영화 reproduce 펀드가입방법 손연재연세대 강원랜드채용정보 초량동출장마사지 바카라게임방법 천안나이트 대사동유흥주점 교동성인게임장 여행체험단 북면가라오케 스포츠쇼핑몰 망가쇼미 여자발라드가수 남부민동키스방 딸자닷컴사이트 방축동대딸방 코섹스 갈현동아로마마사지 커피숍종류 야한동영상다운받는곳 강화대딸방 빨통넷 야한영화보기 서양포르노동영상 비나한인 레인보우엉덩이뽕 로토 서울역출장마사지│시청출장마사지│종각출장마사지 피파온라인2복불복 씨야김연지 Temperley 초지동성인인형체험 중국주식사는법 JYP주식 다보자새주소 세희 통인동토킹bar 다율동리얼돌성인인형 일본에로영화 이탈리아리그순위 상왕동아로마마사지 생계형저축 AV모델 스파이더맨 스터디카페수익 여자친구랑하고싶은일 여자똥침게임 마장동건마 일본모델 명륜동안마 석남동북창pr 삼동북창pr 원카드게임방법 넷츠코 가슴확대비용 봉황동건마 60 오피어때 덕명동성인게임장 서비스 성인비디오테이프 신동풀싸롱 오르가즘젤 음악듣기 DBGMDDJQTH 정가은셀카 19코리안성인 여주유흥문화 남포동대딸방 만년동토킹bar 위너클럽 520연금복권 당정동방석집 최영완 지역별무료채팅 여자가슴확대보기 섹시일반인사진 이율높은예금 바구인구직 교복팬티노출 sexsample 2010드림콘서트방송 호신용전기충격기 로또AC값 이은비 씨알리스파는곳 MS마트 엽총 서윤19 귀여운이미지 허벅지바깥쪽 산성앨엔에스주식 명품오피스룩 해외바카라 이주영 핑클영원 팬티노출녀 대구불교방송 하프라인 나카무라마오 일본프로야구분석 저축성보험연말정산 네이버제비뽑기게임 토토포럼 안원왕 워니잇츠뉴욕 수하동방석집 이슬이 일본축구보기 야한동영상다운받는곳 프리미어12 상일동유흥거리 아기고양이설사 주식학원 남동키스방 화성인바이러스양악수술피해자 투자정보 라라문생리대 sexpotal 571회로또당첨번호 베트남투자 여자연예인스폰서 소비자심리 빠카라 호텔리스보아 대별동안마 구미호스트바 죽정동유흥문화 VGS카지노 대한민국가수순위 무한도전278회다시보기 서포터 아파트그림 새로운걸그룹 듀퐁라이타이미테이션 자수정가격 사기소동나이트 범천동유흥문화 하월곡동토킹bar 아트컨설팅 배미동퍼블릭룸 방송사고노출 도마동룸싸롱 버버리여자지갑 은정엉덩이 갑동레깅스룸 펀툰 ADULT 겜블파티 성기능장애 권상우몸 크리스탈실제키 두산인프라코어주식 수신면키스방 동행복권이란 서종면퍼블릭룸 밤놀 가수가창력순위 미팅장소 체리넷같은사이트 천성동레깅스룸 MANY 파멜라노출 해외블로그사이트 이승기일본방송 VIP24 궁촌동건마 벅스토렌트 일산방석집 전신경락마사지 금동퍼블릭룸 진진 신사동빌리지 가장동북창pr 오동오피 효린직캠
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