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BOUDRY, SWITZERLAND--( / ) October 12, 2015 -- Celgene International Sarl, a wholly-owned subsidiary of Celgene Corporation (NASDAQ:CELG), today announced that the latest research on Otezla® (apremilast), the Company's oral, selective inhibitor of phosphodiesterase 4 (PDE4), will be presented at the 24th European Academy of Dermatology and Venereology (EADV) Congress in Copenhagen, Denmark, October 7-11, 2015. Nine abstracts (one oral presentation and eight e-posters) evaluating the use of OTEZLA in plaque psoriasis and pre-clinical data in atopic dermatitis will be presented at the meeting.

Data to be presented include pre-specified analyses of the LIBERATE study assessing the impact of either oral OTEZLA 30 mg twice daily or weekly subcutaneous (SC) etanercept 50 mg, each compared with placebo, on changes in patient-reported pruritus (itching) and health-related quality of life through 32 weeks of treatment in patients with moderate to severe plaque psoriasis. Efficacy and safety results from the LIBERATE study were previously presented at this year’s Annual Meeting of the American Academy of Dermatology in San Francisco, California. LIBERATE was not designed or powered to directly compare OTEZLA to etanercept.

A retrospective analysis of results from the ESTEEM 1 trial will examine the potential of an alternate tool to measure psoriasis disease severity, particularly in patients with moderate psoriasis. This composite tool, called Physician’s Global Assessment and Body Surface Area (PGAxBSA), will be compared with the Psoriasis Area and Severity Index (PASI) in its ability to measure the effect of treatment with OTEZLA in patients with plaque psoriasis. Improvement in PASI scores is a measurement typically used in registrational trials to examine the effectiveness of plaque psoriasis treatments.

Results from pre-clinical studies assessing the potential of apremilast, the active ingredient in OTEZLA, as a treatment for atopic dermatitis will also be presented. The data will evaluate the effect of apremilast on gene expression in human epidermal keratinocytes (skin cells) that have been stimulated by T helper 2 (Th2) and Th17 cytokines - proteins thought to be associated with skin inflammation. The impact of apremilast treatment on gene expression and skin symptoms in two mouse models of dermatitis will also be investigated. A phase II trial of apremilast in moderate to severe atopic dermatitis is ongoing.

“New data to be presented at EADV will not only further evaluate OTEZLA’s clinical benefit in plaque psoriasis, but also highlight our ongoing commitment to uncovering the potential of OTEZLA in other immune-related dermatologic diseases, such as atopic dermatitis,” said Scott Smith, President, Celgene Inflammation & Immunology. “Furthermore, we are eager to assess the use of alternative endpoints in patients with moderate plaque psoriasis, for which PASI may be a less sensitive measure.”

The following abstracts will be presented at EADV as an exchange of scientific and clinical information (all times, CEST):

Abstracts at a Glance

Oral Presentation FC08.05; Saturday October 10, 2015, 3:36 - 3:45 PM

Apremilast Regulates Human Keratinocyte Gene Expression in Vitro and Reduces Antigen-driven Dermatitis in Vivo; Mary Adams

Location: B3M1-4

Poster Number 1652

Metabolic and Weight Changes with Apremilast in Patients with Psoriasis: Pooled Laboratory Analysis of the Phase 3 ESTEEM 1 and 2 Trials; April Armstrong, MD

Location: e-Poster area

Poster Number P1653

Efficacy of Apremilast or Etanercept Compared with Placebo in Patients with Moderate to Severe Psoriasis: Results From the LIBERATE Study; Jennifer Soung, MD

Location: e-Poster area

Poster Number P1655

Evaluation of the Physician’s Global Assessment and Body Surface Area Composite Tool for Assessing Psoriasis Response to Apremilast Therapy: Results from the ESTEEM 1 Study; Kristina Callis Duffin, MD

Location: e-Poster area

Poster Number 1656

Analysis of Psoriasis Area and Severity Index and Weight Change During Long-term Treatment with Apremilast in Patients with Moderate to Severe Plaque Psoriasis (ESTEEM 1); Kristian Reich, MD

Location: e-Poster area

Poster Number P1658

Safety of Apremilast and Etanercept Compared with Placebo in Patients with Moderate to Severe Psoriasis: Results From the LIBERATE Study; Melinda Gooderham, MD

Location: e-Poster area

Poster Number P1668

Impact of Apremilast or Etanercept on Pruritus and Health-Related Quality of Life in Patients with Moderate to Severe Psoriasis: Results From the LIBERATE Study; Kim Papp, MD

Location: e-Poster area

Poster Number P1706

Cost per Responder of Apremilast Versus Etanercept in Patients with Moderate to Severe Psoriasis Using Results From LIBERATE; Tom Tencer, MD

Location: e-Poster area

Poster Number P1771

Effect of Apremilast and Etanercept on Patient-Reported Outcomes in Patients with Moderate to Severe Plaque Psoriasis in the LIBERATE Study; Melinda Gooderham, MD

Location: e-Poster area

The views expressed and the techniques presented by the speakers at the 24th EADV Congress in Copenhagen, Denmark are not necessarily shared or endorsed by the European Academy of Dermatology and Venereology.


ESTEEM 1 and 2 are two large pivotal phase III randomized, placebo-controlled studies evaluating OTEZLA in patients with a diagnosis of moderate to severe plaque psoriasis for at least 12 months prior to screening, and who were also candidates for phototherapy and/or systemic therapy. Approximately 1,250 patients were randomized 2:1 to receive either OTEZLA 30 mg twice daily or placebo after an initial five-day titration period, for the first 16 weeks, followed by a maintenance phase from weeks 16-32 in which placebo patients were switched to OTEZLA 30 mg twice daily through week 32, and a randomized withdrawal phase for responders from week 32 to week 52 based on their initial OTEZLA randomization and Psoriasis Area and Severity Index (PASI)-75 response (ESTEEM 1) or (PASI)-50 (ESTEEM2).


LIBERATE (PSOR-010; EvaLuatIon from a PlaceBo-controllEd Study of ORal ApremilasT and Etanercept in Plaque Psoriasis) is a phase IIIb, multicenter, randomized, placebo-controlled, double-blind, double-dummy study of the efficacy and safety of OTEZLA, etanercept and placebo, in subjects with moderate to severe plaque psoriasis. The primary objective of the LIBERATE study was to evaluate the clinical efficacy and safety of oral OTEZLA 30 mg twice daily compared with placebo at week 16. Secondary objectives of the study included: the evaluation of the clinical efficacy and safety of etanercept 50 mg SC once weekly (QW) compared with placebo at week 16 and the evaluation of the relative safety of a crossover from etanercept to OTEZLA 30 mg twice daily, as compared with OTEZLA dosed since week 0, after week 16. Subjects were required to have inadequate response, intolerance or contraindication to at least one conventional systemic agent and no prior exposure to biologics. The study enrolled 250 subjects who were randomized 1:1:1 to receive OTEZLA 30 mg twice daily, etanercept 50 mg QW or placebo, for 16 weeks. Following the first 16 weeks, all subjects were switched to (or continued on) OTEZLA 30 mg twice daily through week 104. The primary endpoint was the proportion of subjects with either OTEZLA 30 mg twice daily or placebo who achieved PASI-75 at week 16. Secondary endpoints included other measures of disease activity and quality of life for the comparison of OTEZLA 30 mg twice daily versus placebo and the comparison of etanercept 50 mg SC QW versus placebo.


OTEZLA is an oral small-molecule inhibitor of phosphodiesterase 4 (PDE4) specific for cyclic adenosine monophosphate (cAMP). PDE4 inhibition results in increased intracellular cAMP levels which is thought to indirectly modulate the production of inflammatory mediators. The specific mechanism(s) by which OTEZLA exerts its therapeutic action in patients with psoriasis or psoriatic arthritis is not well defined.

OTEZLA is approved:

△ In the European Union:

· For the treatment of moderate-to-severe chronic plaque psoriasis in adult patients who failed to respond to or who have a contraindication to, or are intolerant to other systemic therapy including cyclosporine, methotrexate or psoralen and ultraviolet-A light (PUVA)

· Alone or in combination with Disease Modifying Antirheumatic Drugs (DMARDs), for the treatment of active psoriatic arthritis (PsA) in adult patients who have had an inadequate response or who have been intolerant to a prior DMARD therapy

△ In Switzerland:

· For the treatment of adult patients with moderate to severe plaque psoriasis who have not responded to another systemic therapy or do not tolerate such therapy or where such therapy is contraindicated

· As monotherapy or in combination with disease-modifying anti-rheumatic drugs (DMARDs) for the treatment of active psoriatic arthritis in adults who have not responded to a previous DMARD therapy, who have not tolerated it, or where DMARD therapy is contraindicated

△ In the U.S.:

· For the treatment of adults with active psoriatic arthritis

· For the treatment of patients with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy

△ In Canada:

· For the treatment of patients with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy

· For the treatment of active psoriatic arthritis, alone or in combination with methotrexate, in adult patients who have had an inadequate response, intolerance or contraindication to a prior disease-modifying anti-rheumatic drug (DMARD).

△ In Australia:

· For the treatment of signs and symptoms of active psoriatic arthritis in adult patients

· For the treatment of adult patients with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy

Important Safety Information (based on US labeling)


Otezla® (apremilast) is contraindicated in patients with a known hypersensitivity to apremilast or to any of the excipients in the formulation.

Warnings and Precautions

Depression: Treatment with OTEZLA is associated with an increase in adverse reactions of depression. During clinical trials, 1.0% (10/998) of patients treated with OTEZLA reported depression or depressed mood compared to 0.8% (4/495) treated with placebo; 0.3% (4/1441) of patients treated with OTEZLA discontinued treatment due to depression or depressed mood compared with none in placebo treated patients (0/495). Depression was reported as serious in 0.2% (3/1441) of patients exposed to OTEZLA, compared to none in placebo treated patients (0/495). Suicidal ideation and behavior were observed in 0.2% (3/1441) of patients on OTEZLA, compared to none on placebo (0/495). Two patients who received placebo committed suicide compared to none on OTEZLA.

Carefully weigh the risks and benefits of treatment with OTEZLA for patients with a history of depression and/or suicidal thoughts/behavior, or in patients who develop such symptoms while on OTEZLA. Patients, caregivers, and families should be advised of the need to be alert for the emergence or worsening of depression, suicidal thoughts or other mood changes, and they should contact their healthcare provider if such changes occur.

Weight Decrease: Body weight loss of 5-10% was reported in 10% of patients taking OTEZLA and in 3.3% of patients taking placebo. Monitor body weight regularly; evaluate unexplained or clinically significant weight loss, and consider discontinuation of OTEZLA.

Drug Interactions: Apremilast exposure was decreased when OTEZLA was co-administered with rifampin, a strong CYP450 enzyme inducer; loss of OTEZLA efficacy may occur. Concomitant use of OTEZLA with CYP450 enzyme inducers (eg, rifampin, phenobarbital, carbamazepine, phenytoin) is not recommended.

Adverse Reactions

Adverse reactions reported in at least 2% of patients taking OTEZLA, that occurred at a frequency at least 1% higher than that observed in patients taking placebo, for up to 16 weeks (after the initial 5-day titration), were (OTEZLA%, placebo%): diarrhea (7.7, 1.6); nausea (8.9, 3.1); headache (5.9, 2.2); upper respiratory tract infection (3.9, 1.8); vomiting (3.2, 0.4); nasopharyngitis (2.6, 1.6); upper abdominal pain (2.0, 0.2).

Use in Specific Populations

Pregnancy and Nursing Mothers: OTEZLA is Pregnancy Category C; it has not been studied in pregnant women. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether apremilast or its metabolites are present in human milk. Caution should be exercised when OTEZLA is administered to a nursing woman.

Renal Impairment: OTEZLA dosage should be reduced in patients with severe renal impairment (creatinine clearance less than 30 mL/min); for details, see Dosage and Administration, Section 2, in the Full Prescribing Information.

Please click here () for Full Prescribing Information.

About Celgene

Celgene International Sarl, located in Boudry, Switzerland, is a wholly-owned subsidiary and international headquarters of Celgene Corporation. Celgene Corporation, headquartered in Summit, New Jersey, is an integrated global pharmaceutical company engaged primarily in the discovery, development and commercialization of innovative therapies for the treatment of cancer and inflammatory diseases through gene and protein regulation. For more information, please visit Follow Celgene on Social Media: @Celgene (), Pinterest (), LinkedIn () and YouTube ().

Forward-Looking Statements

This press release contains forward-looking statements, which are generally statements that are not historical facts. Forward-looking statements can be identified by the words “expects,” “anticipates,” “believes,” “intends,” “estimates,” “plans,” “will,” “outlook” and similar expressions. Forward-looking statements are based on management’s current plans, estimates, assumptions and projections, and speak only as of the date they are made. Celgene Corporation undertakes no obligation to update any forward-looking statement in light of new information or future events, except as otherwise required by law. Forward-looking statements involve inherent risks and uncertainties, most of which are difficult to predict and are generally beyond Celgene’s control. Actual results or outcomes may differ materially from those implied by the forward-looking statements as a result of the impact of a number of factors, many of which are discussed in more detail in Celgene’s Annual Report on Form 10-K and other reports filed with the U.S. Securities and Exchange Commission.

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어덜비 미스코리아한성주 진정한하의실종 안락동떡집 홀덤사이트 태연갤러리 펜트하우스코끼리전세홍 임사랑 춘자넷서양야동 acknowledged 김태우cosmicgirl 아나운서강수정 사설카드사이트 미싱도로시원피스 블루콤주식 딸기넷 무료실시간tv어플 FCMTarguMures 수영동대딸방 터보라이터 2009한국바둑리그 김해유흥문화 PORNDIG일본야동 처녀막재생 야한만화동영상 마이클잭슨노래 대방역로또 박은지아나운서노출 대중문화예술 풍기동성인용품 별킹 주식하는법 즉석만남어플 미천왕 스페인라리가2 비대면계좌개설수수료 전곡읍레깅스룸 런닝맨키스앤크라이 정장벨트 색스장면 축구픽 가수란 행정동나이트 야탑출장안마│서현출장안마│홍대출장안마 미우미우클러치 강원랜드칩걸 사노동성인인형체험 노르웨이 박효신나처럼 암웨이생리대 인테리어디자인 여자연예인인기순위 tv야한방송 나라 양요섭복근 야색마 문산퍼블릭룸 양현동레깅스룸 유망주식 소호동유흥주점 망가관 카스미하루카 밤알바사이트 덕정동풀싸롱 asiansexvideo AQSTREAM 남성링 1억재테크 여성섹스 sexyphoto 종각술집 란스크로나BolS 지방시클러치 월드바카라게임 일본여자색스 javhdmovies 영등포본동방석집 커프스 대림 writing 폭시에브 야찾사새주소 성욕구 HUNLC 첫상방송 롯도당첨번호 광교동성인인형체험 성인용품쇼핑몰추천 증시일정 캐뉼라 신사넷 하역망 [채병용]SK 염창동토킹bar 오른주식 빅파일 엘크라넬 박차 샤르코드 방자전링크 쇄골미인 만화누드 달력프린트 패밀리가떴다제시카 로또연금사이트 EGGC 석남동대딸방 소녀시대잠옷 베이비수영복 드림하이아이유 뒤태의유혹 야동나라 사동오피 감정동유흥문화 둔산동퍼블릭룸 flickr다운로드 종자돈굴리기 아이유은혁사건총정리 해외성인방송 아이돌서열 먹튀중개소 먹중소) 대구케이블방송 펀비넷 주암동노래방 노란국물동영상 메타바이오메드주식 관저동유흥거리 카지노이름 충정로출장마사지│서대문출장마사지│광화문출장마사지 풍무동건마 대항동퍼블릭룸 어남동룸싸롱 FC토르페도모스크바 까르띠에카드지갑 샤넬중지갑 추천바다최신버전 AD 주식투자실패담 대구외국인카지노 주식인생대역전 애프터스쿨뱅뮤직뱅크 취암동성인게임장 일반인노출녀 온라인카지노 코리아스코어 안산건마 연산동성인인형체험 엔조이 여의도토킹bar slm 신기동풀싸롱 부킹클럽 강남클럽흰티녀 메가밀리언스 넥솔론주식 오형제 매일매일퀴즈이벤트 통합검색결과 65g다운받으면 자작동룸싸롱 우에노쥬리 변액 손나은비리 69노리 짝사랑맛있는색스그리고사랑 작은가슴속옷 에로영화순위 궁정동리얼돌성인인형 신혼속옷 로또580회예상번호 비대면계좌수수료 로또오행가격 고혈압발기부전 한광주식 돈의화신황정음목걸이 송내동출장마사지 정인영아나운서학력 장기금융상품 전효성털기 신대동성인인형체험 갈산동성인게임장 몸매좋은일반인 영어로나와요 타짜카지노주소 칠산동대딸방 섹시한여자아이돌 대창단조주식 love 중딩슴가 유키스수현게이 교복다리 루이비통카드지갑 조루방지용콘돔 추석이란 구로동나이트 눈높이증권 최강희나이 글로벌투자 일본성인소설 sm신인그룹 구서동건마 여지우 소라스포 조개닷컴 에로영화사이트 관평동건마 신상동대딸방 옵션매수계좌 국내성인물사이트 내항동출장마사지 이베스트리서치 바보스탁 부산택시파업 솔비닮은그녀 이쁜커트머리 영등포본동레깅스룸 일산나이트 훌라 텀블러야동 가슴을보여주는여자 셀리 주식값 제주도유흥문화 하드코어 오션파라다이스예시 야한성인게임 모바일바둑 투자 KINDEX삼성그룹EW주식 야동망고 컴퓨터로부업 여탑 스포츠중계바셀TV 카지노꽁머니 야한동영상천국 중국유출 유기농본프리미엄 가슴수술비용 무한도전영어마을 돈의화신서신애 승마바지 [1이닝무득점]야쿠르트 팬티속으로손이 충무동성인인형체험 배다해쇼핑몰 구포동안마 코코토렌트 스페인축구 일산성인용품 남동유흥거리 마곡동방석집 플래시주사위게임 신화플레이어 대구인터불고카지노 mbc뉴스투데이 로하이로우 HTS강의 중외신약주가 야한동영상색스코리아 야한동영상보면 공짜화상채팅사이트 주전자닷컴 지상렬의노모쇼시즌1 신화선물 세상에서가장어려운게임무적판 남자의생식기 차움 이중두뇌선종류 극동보석 오동아로마마사지 만수TV 중계동대딸방 파는곳토킹bar 울산유흥거리 알파칩스주식 mtv소녀시대제시카 레드썬 까망아이즈 티팬티노출 롤리스킨 테라젠이텍스주식 야동리 여자가슴크기 성북동노래방 딸친구새주소 남천동떡집 블랙잭레나트휼스트롬 이름궁합테스트 먹튀뷰 토렌트소닉 성인포털 텍사스홀덤룰 제주성인게임장 해피스탁 수지가슴보기 동행복권파워볼점검 사기소동퍼블릭룸 색스소리 효린성형전 브레이브걸스아나요안무 중고터치폰 암남동유흥거리 KTSK분석 산타넷 아스카키라라 개봉동텍사스홀덤 자양4동성인오락실 금암동인싸포커 백학면홀덤바 색스만화이름 크리스탈영어로 화양동성인오락실 천호2동오마하홀덤 대청동레깅스룸 석남동떡집 학동인싸포커 원문동홀덤카페 김유미학교 손연재남자친구 바다매니아 고추맛집 찌찌살 배지현각선미 소녀시대유리키 영통동안마 부대동키스방 동산동홀덤룰 나와그녀의xxx 중동홀덤카페 여성섹스용품 경원동홀덤카페 이파니효도르 이민정이상우키스신 구래동립카페 헨타이폭스 부평구립카페 바디온_비키니 팔복동홀덤룰 나이트섹시댄스 와우카페 카라김성희 고잔동노래방 고등학생장난동영상보기 아이유아프리카 토토나라 마포동인싸포커 범빙빙 송중동출장마사지 노출녀쇼핑몰 이린 배꼽가슴확대 우결한선화비키니 양대동레깅스룸 신인여가수 신민아몸매 고랑동카지노펍 성내동성인게임장 성인색스기구 짜주고싶다 일산동구인싸포커 66년말띠모임 세상에서가장쉬운미로게임 온라인게임사이트 당산1동홀덤대회 야마토2014주소 여자생식기사진 포토샵으로사진합치기 장동리얼돌성인인형 빅사이즈사각팬티 복산동풀싸롱 소양로홀덤룰 병천면떡집 창신동홀덤족보 수지중학교졸업사진 사용자정보수정 별빛큐리 팬엔터테인먼트주식 양말쇼핑몰 금동홀덤룰 해태 엉덩이살빼는법 송정동노래방 내장동성인오락실 성인플래쉬 기산동성인게임장 개화동카지노펍 블로그디자인 소리엘1집 오피덱스 강상면포커고수 도곡1동홀덤족보 워너b 까르띠에커플링 도화동유흥문화 LA밤알바 효자동카지노펍 최신외국영화 인후동홀덤족보 싸이월드비공개사진 한소중 왕정동오마하홀덤 부메랑쇼 소양로모바일홀덤 가남읍홀덤룰 낙원동텍사스홀덤 소리티비 분당퍼블릭룸 한국전통요정 색스장면보기 야마토2다운 그여자백지영 주현동오마하홀덤 이사동토킹bar 놀고가닷컴 노인무임승차폐지 못말리는색스아카데미2 appreciate 선장 사진두개붙이기 과해동오마하홀덤 구수동홀덤족보 가산동방석집 김지연 구암동포커고수 아이러브사커 둔촌1동홀덤족보 하루의단기스윙주 매화동오마하홀덤 전효성허리돌리기 둔촌동토킹bar 가슴애무 서초구노래방 안혜경h컵 인화동성인게임장 교암동홀덤룰 설운동홀덤대회 이도동텍사스홀덤 운봉읍홀덤룰 c팬티후기 베스트초이스 은계동홀덤펍 명일2동홀덤대회 ED-1000 케리힐슨 뉴발란스이효리 청수동성인인형체험 코비몽글몽글 봉양동룸싸롱 영동성인오락실 과천동리얼돌성인인형 양요섭볼수록애교만점 고준희패션 정력증강 김범수-theoneinmylife 유천동유흥문화 법곡동성인인형체험 김종국송지효 온천동떡집 여자엉덩이보기게임 마린보이결말 메이플스토리영웅직업추천 서프라이즈배우 푸른소금노출 원더걸스인기카페 내깡패같은애인 원정동토킹bar 혜화동성인오락실 흑석동성인오락실 미백기능 노홍철무도레전드 송지효쌍화점 프라다남성지갑 김수정키 중국레이싱걸유출 mcm가방추천 발롱펌 영동포커고수 동선동5가텍사스홀덤 관고동텍사스홀덤 황산면포커고수 부천메리트나이트 빅쇼직캠 스포츠한국 동완산동텍사스홀덤 스탕다르리에주 개포4동모바일홀덤 향교동홀덤바 괴안동텍사스홀덤 플래시게임19금 농소동홀덤대회 10월테마주 일본2ne1 두정동유흥거리 sexylove 오피싸롱 권지용황미영 색스코리아다컴 kbs스포츠 키타노타케시 서울택시회사 성당면홀덤룰 월송동유흥거리 삼화동텍사스홀덤 회암동성인게임장 10대패션블로그 청학동노래방 관저동떡집 젖팔계 도마교동가라오케 드림하이옥택연노래 SJKSeinajoki 오마이툰 삼소고 대구코넬 10CC주사기 웃긴동영상몰래카메라 태연갤러리 녹번동북창pr 정자동립카페 옹박더레전드다시보기 웅천읍건마 노암동오마하홀덤 싸이새친구 지변동텍사스홀덤 의왕홀덤룰 이이오카카나코 엘라호야속옷 프로토분석 몰캉 맛있는색스그리고사랑 란제리도매 구기동홀덤룰 커플모임 팩트스포 광복동떡집 장항동퍼블릭룸 테마주분석 xtm 주가지수예측 하나금융지주주식 조촌동홀덤카페 발산1동홀덤펍 동현동아로마마사지 가리봉동나이트 성북동성인게임장 최민식 남자연예인머리스타일 송풍동텍사스홀덤 리본타이나나 성내동가라오케 여성언더웨어 좌동떡집 가슴예쁜 팔달구홀덤룰 부전동퍼블릭룸 남자가수다이어트 헨타이러브TV 운봉읍성인오락실 탑립동나이트 상승전환 야동동키스방 논현2동성인게임장 고고스탁 전미동모바일홀덤 샤넬남자지갑 금마면텍사스홀덤 금흥동북창pr 2011년개봉한국영화 구완동성인게임장 이쁜외국연예인 송정동나이트 신부동아로마마사지 역사상 아이디변경 김정민스타화보 서암동포커고수 삼산동건마 부곡동토킹bar 인의동홀덤펍 불교tv 이명박북한지원 용동카지노펍 싸이사진 효자동텍사스홀덤 영화추천 한지나 종로4가동성인게임장 효민연습실 이준여자친구 성환읍립카페 세상에서제일큰고추(남자의성기) 영문레터링 원유주식 가라오케DJ 흑석동모바일홀덤 평점제일높은영화 명일동홀덤족보 하왕십리동성인게임장 김포모바일홀덤 명륜동카지노펍 러브나인 천호동홀덤바 섹스잘하는 망미동레깅스룸 예쁜여중생 섹스인터넷 은평구북창pr 신림면성인오락실 아이돌가창력순위 누나만 강하면레깅스룸 라니아drfeelgood뮤비 에스폴리텍주식 동면풀싸롱 비욘세노래모음 올레벳 유니테스트주식 동선동2가성인게임장 성인영화무료다운로드 경암동홀덤족보 논현동카지노펍 십정동오마하홀덤 귀여운남자연예인사진 양상동아로마마사지 PatronatoParana 신용동홀덤카페 철산동유흥주점 한유라 호성동오마하홀덤 망사스타킹 RO-I2 노출현아 방동성인인형체험 CCI 덕진동홀덤카페 당산동5가홀덤족보 봉의동오마하홀덤 노출과다모델 TSV하벨스 가인속옷모델 드림하이옥택연폰 광안동키스방 주촌동유흥주점 부산동모바일홀덤 대평동퍼블릭룸 LA밤알바 전곡읍유흥주점 농구사이트 동현동풀싸롱 신동카지노펍 성산면카지노펍 가로수길카페 고야드가방 남항진동카지노펍 이진희노출 내곡동포커고수 이기동오마하홀덤 상산곡동퍼블릭룸 여자가수노래추천 필운동모바일홀덤 먹튀폴리스심바 해외선물프로그램 박해진머리 자금관리 안전놀이터 연애인도끼 성남동유흥주점 7포커잘치는법 오도동대딸방 함부르크SV(Am) 과천떡집 일직동가라오케 버디버디채팅 부산사건사고 jyp걸그룹 슈어맨2미스터그린 포도닷컴 신천노래주점 오전동노래방 sexywallpaper 6개월아기수영복 주식거래 베스트초이스사이트 신일동립카페 무료감명섹스앤더시티무료감상 딸타임 중앙동레깅스룸 에블토토 연예인동영상유출 국산야동 해외안전놀이터 지산동퍼블릭룸 강원랜드복지재단 수빈이넷 경마왕강성국 서든어택수지노출 남자모델 오도동가라오케 강서구룸 cream 석봉동토킹bar 여대생남극탐험 씨스타헬로베이비 화암동성인인형체험 구리나이트 슈어맨같은곳 고려아연주식 야한동영상샘플 롤러코스터2 슈어맨삽니다 연애인비디오 주식개미 남포동토킹bar 수라검제 영계백숙동방신기 남자사파리야상 색스쇼 롯데아이몰 야동넷주소찾기 와촌동유흥거리 먹튀검증 풍기동키스방 70kg다이어트 김연아공식연습 로또그래프 도우미사이트 광주시동구건마 먹튀검증커뮤니티 강상면유흥주점 마카오홀덤전업을 주식투자시작하기 도메인이 동작동안마 일반인브라노출 윈도우8모두의마블 사직동아로마마사지 여자247 천송동출장마사지 사진뷰어 월남뽕게임 체위법 석림동나이트 소변 민카켈리 상산곡동방석집 rcx09호 지산동성인인형체험 producer 우리결혼했어요유니나 토토보증업체 야한SEX 정발산동건마 박지성과외선생님 김연아세계선수권중계 파워볼먹튀검증 긴급대출 인창동노래방 파마머리 서원주식 2ne1노출 녹번동키스방 JAV베드트위터 2001년영화 픽앤촉 안전놀이터 플레잉보이 이도경무한도전 야한섹시사진 오르가즘느끼는 꽃보다남자x파일18화 신정환카지노 브랜드팬티 성인사이트목록 SJM주식 제약주식 라스베이거스카지노 케이리그득점왕 maturesex Supporter토토 먹튀폴리스검증업체 핑크69 무료주식강의 로또시뮬 이서현자살이유 티아라보람임신 오천면유흥주점 알파카코믹스 웅진동건마 네이키드파라다이스 dfx 글로벌채권펀드 재혼사이트 Chiasso 석우동북창pr 슈어맨계정 먹튀폴리스검증업체 장대동레깅스룸 뉴스동영상 사직동가라오케 쌍문동성인용품 미산동노래방 이환경드라마 조권윤아 서대문출장마사지│종로출장마사지│은평출장마사지 섹스사이트보기 고딩각선미 호르몬대체요법 티브로드도봉강북방송주식 뉴캐슬유나이티드 재무설계 룸구직 지연예쁜사진 야동다모아 오렌지캬라멜쿠키크림앤민트 폴더공유 무료감명섹스앤더시티무료감상 이그잭스주식 먹중소먹튀검증사이트 하기스 대야미동유흥거리 악녀일기 섹스토이샵 도선동립카페 안전놀이터 하이원스키대여 추천바다껨 윙스톰1년사용후기 로또랜덤 비즈니스접대 커플사각팬티 섹남 동방신기새드무비 슬립가운 주식투자베스트비법 악력 사설먹튀검증 포털 터치걸어플 박다현 샤넬선글라스 애프터스쿨리지고등학교 불후의명곡2 지나firstkiss 포토샵합성이미지 도봉동성인인형체험 나프트테헤란FC 룸구인 그래픽쩌는 RacingClubMontevideo 덕암동성인인형체험 라이브블랙잭사이트 야한천사링크 언니알바 밤헌터 js아카데미 추천바다추천스톰껨 윙크tv지아 소녀시대댄스동영상 김슬기너땜에잠이깨 참테크주식 로또몬 영민광민구별 인피니트강한문답멀티방 섹스천국 내항동성인게임장 니까짓게가사 인천유흥문화 외국노출영화 법동토킹bar 명동사 월드컵배트맨 지나피멍든무릎 피에타 2011테마주 풋옵션매수방법 김연아예쁜이미지 죽동유흥문화 딸잡go주소 기상레이더 불가리여성지갑 광주영어 유니버시티커리지더블린AFC.. 선생님에대해서 특수콘돔 flickrapi 엉덩이회초리만화 대청출장안마 모아따커뮤니티 여탑 하기동건마 트리믹스가격 취암동룸싸롱 증일동성인게임장 질건조증치료방법 동시호가 이효리노출화보 1억만들기 라이브스코어사이트 교복노출녀 케이앤컴퍼니우주식 반여동방석집 일베걸그룹 swat4공략 애니섹스 바로만남 ebod228 하츠미사키 bikini 장염설사 문채원사투리 유방애무 미국로또번호 리치클럽 덕암동북창pr 청계동성인용품 안나블라소바 섹만화 하라넷 정소민못생김 무료성인싸이트 영웅문S가입 피엘에이주식 폭딸넷사이트 스윙매매기법 이세상에서가장웃긴놀이기구 울산출신연예인 해외채권펀드 치마속풍경 본동키스방 로또572회로또당첨번호 롤러코스터99화 스마트폰부업 축구전력분석 양방사무실 주식이야기 야한사진모음 아나요뮤비 백경릴개임 요정집 스타킹색스 벳익스플로러 먹튀넷 김연아경기중계동영상 남성확장링 무한도전의좋은형제 제일약품주식 짤뱅크 팔팔약국 에로영화감상 어룡동리얼돌성인인형 강타상록수 도화동방석집 케이섹스 백진희야상 REBLOP 주니치[1이닝득점] 섹스한밤 619회차로또당첨번호 수지피팅모델 박초롱몸매 온천동룸싸롱 석촌동키스방 카스미카호 프라다사피아노벨트 검상동가라오케 여자친구랑관계 여자아이돌그룹막내 86년생여자연예인 은평구유흥거리 ALABOUT fivetimetwo 허그팬티임신 남구풀싸롱 김혜수d컵 김라나 남포동출장마사지 외삼동오피 오마주폴더 블로그사진다운 윤승아머리 엑스비디오 일반인남자 파트너구함 영국아이돌 배변팬티 망고 리지해피투게더 간루루전신노출 배우가되려면 조은세상 종합금융회사 오인혜허리돌림움짤 후기가라오케 미술품구매 교육사업 동영상진도희 바다이야기릴게임 금성동성인인형
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