bboyangirl.com루리웹오카모토사진 > 용인점

본문 바로가기

본문

bboyangirl.com루리웹오카모토사진

루리웹<- 바로가기

NEW ORLEANS & OSAKA, JAPAN--( / ) December 10, 2013 -- Takeda Pharmaceutical Company Limited (TSE:4502) today announced final Phase 1 and preliminary Phase 2 results of a study combining oral investigational MLN9708 administered twice a week with lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma (MM). The investigators reported a combined complete response and very good partial response (CR+VGPR) rate of 76 percent (46/62) and a 94 percent overall response rate (ORR; 58/62 ≥ partial response). Stringent complete response (sCR) was reached in 75 percent of patients that attained CR. Overall, drug-related serious adverse events (SAEs) were reported in 28 percent of patients (18/64), and drug-related grade 3 adverse events (AEs) in 58 percent of patients (37/64). There were no drug-related grade 4 AEs. These data were presented today at the 55th American Society of Hematology (ASH) annual meeting held December 7-10 in New Orleans, LA.

“This all-oral MLN9708, lenalidomide and dexamethasone study generated high response rates and increased depth of response with extended treatment duration in newly diagnosed multiple myeloma patients,” said lead investigator, Paul G. Richardson, MD, Dana-Farber Cancer Institute, Boston, MA. “This is the first all-oral proteasome inhibitor, IMiD combination under investigation in this setting to date, and the data support its feasibility and activity.”

“The safety profile and encouraging response rates presented at ASH for the twice-a-week oral MLN9708 combination supplement our clinical understanding of this all-oral triplet regimen in newly diagnosed multiple myeloma patients,” said Michael Vasconcelles, MD, Head, Oncology Therapeutic Area Unit. ”Bringing new therapies to patients is an important goal, and the oral MLN9708 combination has the potential to become yet another way to extend proteasome inhibition. Based on data from this and another Phase 1/2 study, we are further exploring oral MLN9708 in our TOURMALINE Phase 3 development program using a once-a-week dosing schedule.”

MLN9708 is an investigational, oral proteasome inhibitor being developed for the treatment of patients with MM and Amyloid Light-chain (AL) Amyloidosis. It is the first oral proteasome inhibitor to enter Phase 3 clinical trials.

Twice-Weekly Oral MLN9708, an Investigational Proteasome Inhibitor, in Combination with Lenalidomide (Len) and Dexamethasone (Dex) in Patients (Pts) with Newly Diagnosed Multiple Myeloma (MM): Final Phase 1 Results and Phase 2 Data (Abstract #535)

This oral presentation provides final Phase 1 results and Phase 2 data of a Phase 1/2 study. The primary objective of Phase 1 was to determine the safety, tolerability, maximum tolerated dose (MTD) and recommended Phase 2 dose; the primary objective of Phase 2 was to determine response rates (CR+VGPR) and further evaluate safety and tolerability. In this Phase 1/2 study, patients received MLN9708, lenalidomide and dexamethasone for up to 16, 21-day cycles, followed by MLN9708 maintenance until disease progression or unacceptable toxicity. Transplant-eligible patients could undergo stem cell collection after at least four cycles, and discontinue for autologous stem cell transplant (ASCT) after at least eight cycles. Key findings from the study, which were presented by Paul G. Richardson, MD, include:

· Phase 1: ? Patients received MLN9708 3.0 mg (n=7) and 3.7 mg (n=7).

? No adverse events met dose-limiting toxicity (DLT) criteria in cycle 1 at either dose of MLN9708.

? Based on overall tolerability, including incidence of rash at 3.7 mg, a 3.0 mg fixed dose was recommended for Phase 2.

? The most common drug-related AEs included rash-related (71 percent; 10/14), peripheral neuropathies and fatigue (64 percent each; 9/14) and peripheral edema (50 percent; 7/14).

· Results from patients receiving recommended Phase 2 dose (RP2D): ? Fifty-seven patients were enrolled at the 3.0 mg dose of MLN9708.

? At data cut-off, the median number of cycles of therapy was nine (range 1-30). ? Seventy-nine percent (45/57) received at least eight cycles and 16 percent (9/57) received at least 16 cycles of treatment.

? Based on 56 response-evaluable patients treated at the RP2D, preliminary data showed deepening responses over the course of treatment, with 93 percent ORR after four cycles (≥61% VGPR) and 95 percent ORR overall (≥ 71% VGPR).

? 26 percent of patients that received RP2D (15/57) remained on therapy at data cut-off.

? Among the 11 evaluable patients who achieved a sCR + CR, an assessment of minimal residual disease (MRD) was conducted, and nine patients were MRD negative.

? Grade 3 drug-related AEs at the RP2D were reported in 56 percent of patients (32/57), with AEs leading to dose reduction in 56 percent (32/57) and discontinuation in 12 percent (7/57) of patients reporting AEs. ? Grade 3 drug-related AEs (≥5% total) included rash-related AEs (11 percent; 6/57), hyperglycemia (9 percent; 5/57), pneumonia (7 percent; 4/57), thrombocytopenia, decreased lymphocyte count, hyponatremia, neutropenia and peripheral neuropathies (5 percent each; 3/57).

? All grade drug-related adverse events (≥20 percent) included peripheral neuropathies (53 percent, 30/57), fatigue (47 percent, 27/57) and rash-related AEs (44 percent, 25/57).

? There was one on-study death due to cardio-respiratory arrest, likely a pulmonary embolism. The investigator reported this event as probably related to lenalidomide, and not to MLN9708 or dexamethasone.

At data cut-off, 33 percent (21/64) of patients overall discontinued to undergo ASCT, a further 17 percent (11/64) discontinued due to AEs, 9 percent (6/64) due to progressive disease and 16 percent (10/64) for other reasons.

About Multiple Myeloma

Multiple myeloma is the second most common hematologic malignancy. In the U.S., more than 77,000 individuals have MM1 and over 22,000 new cases are diagnosed each year.2 Worldwide there are approximately 86,000 new cases and more than 63,000 deaths annually.3

About MLN9708

MLN9708 is an investigational oral, proteasome inhibitor, which is being studied in multiple myeloma and other malignancies. It is the first oral proteasome inhibitor to enter Phase 3 clinical trials. Three global Phase 3 trials are ongoing; TOURMALINE-MM1, investigating MLN9708 in combination with lenalidomide and dexamethasone in relapsed and/or refractory MM, TOURMALINE-MM2, investigating MLN9708 in combination with lenalidomide and dexamethasone in patients with newly diagnosed MM who are not eligible for transplantation, and TOURMALINE-AL1, investigating MLN9708 plus dexamethasone in patients with relapsed or refractory light chain amyloidosis (AL). For additional information on the ongoing Phase 3 studies please visit

About Takeda

Located in Osaka, Japan, Takeda is a research-based global company with its main focus on pharmaceuticals. As the largest pharmaceutical company in Japan and one of the global leaders of the industry, Takeda is committed to strive towards better health for people worldwide through leading innovation in medicine. Additional information about Takeda is available through its corporate website,

Editors’ Note: This press release is also available under the Media section of the Company’s website at:

1 “SEER Stat Fact Sheets: Myeloma.” National Cancer Institute. Last accessed November 21, 2013.

2 “Cancer Facts & Figures 2013.” American Cancer Society. 2013. Last accessed November 20,2013. Page 4.

3 Becker N. (2011). Epidemiology of Multiple Myeloma. In T. Moehler, H. Goldschmidt (Eds.), Multiple Myeloma. (p. 25). New York: Springer-Verlag Berlin Heidelberg. (Available online: )Korea Newswire distributes your news across every media channels through the industry’s largest press release distribution network

INGELHEIM, GERMANY & OXFORD, ENGLAND--( / ) October 15, 2020 -- Boehringer Ingelheim and Oxford BioTherapeutics Ltd. (OBT) today announced they are building on their successful partnership and are establishing a new alliance to discover additional selective targets for strategic cancer indications to deliver first-in-class treatments for cancer 웃긴대학 위야넷 patients. Boehringer Ingelheim will use OBT’s OGAP® platform to identify novel target opportunities 웃긴대학 for new immunotherapies 오늘의유머 INGELHEIM,their T-cell engager, cancer vaccine and oncolytic virus platforms. This follows the initiation of the first patient 인연 INGELHEIM,in a Phase 1 clinical trial of a bispecific antibody for 인연 INGELHEIM,treatment of patients with small cell lung carcinoma and other neoplasms, where the target for the bispecific antibody was discovered during the first phase of the partnership.



“This collaboration with Oxford BioTherapeutics is important for advancing therapeutic modalities that depend upon the identification of unique and specific tumor antigens within our cancer immunology 웃긴대학 portfolio,” said Jonathon Sedgwick, 인연 “ThisSenior Vice President and Global Head Cancer Immunology & Immune Modulation Research at Boehringer Ingelheim. “We 웃긴대학 조이밤 are committed to 웃긴대학 developing innovative, efficacious and safe treatment options for patients suffering from cancer, and these novel cancer target discoveries are a key step in the development of new potential treatments.”



“We view the hopeful discovery of additional 빨간딱지 “Wetargets as further 웃긴대학 소라스포 confirmation of the value of our OGAP® platform to identify novel targets that can be 웃긴대학 미호의 substrates for innovative new therapies,” said Christian 제이제이 “WePh.D., Chief Executive Officer of OBT. “OBT’s platforms KIA[양현종] “Wedesigned to discover and validate novel therapeutic targets and we look forward 웃긴대학 to continuing our partnership with Boehringer Ingelheim to best address difficult-to-treat cancers.”



In addition to the programs in the partnership with Boehringer Ingelheim, OBT’s clinical assets have also been enabled through the OGAP® discovery platform. Selecting the 웃긴대학 시크릿사랑은move right target is fundamental for the successful development of a truly first-in-class oncology product. OBT’s platforms are designed to discover novel therapeutic targets and engineer antibodies to those targets, including CAR-T, other T-cell and NK cell-mediated cytotoxicity (ADCC) therapeutics to best address difficult-to-treat cancers. A major differentiator between OBTs 라이브69 Inplatform and other approaches is 웃긴대학 전효성고화질바탕화면 the retention of the link between individual patient samples through to the design of therapeutic 웃긴대학 섹스도시 antibodies and diagnostic patient selection tools, increasing the overall successful transition into clinical development.



Financial terms of the expanded agreement 웃긴대학 AVYA are not being disclosed. Under the terms of the agreement, Boehringer 웃긴대학 표현력 Ingelheim is responsible for the development and commercialization of antibody product 웃긴대학 야동하우스 candidates that interact with the novel targets identified by OGAP®. OBT will receive development and regulatory milestone payments and royalties on any future product sales. To date, Boehringer Ingelheim has 야동모아 Financialtwo options under the first agreement and has selected two therapeutic candidates 야동모아 Financialfurther development.



Boehringer Ingelheim 웃긴대학 망가주키 Oncology is taking cancer on by leading the science with cancer cell directed agents, immuno-oncology therapies and their combinations to address unmet needs in lung and gastrointestinal cancers. 야동모아 Boehringer웃긴대학 남규리시구 company invests significantly in 웃긴대학 봉가캠 early stage research to identify unexplored and undrugged pathways of cancer. Learn more about Boehringer Ingelheim’s innovation in oncology here ().



Please click on the following link for 웃긴대학 명품코민효린 ‘Notes 홍콩선상카지노 PleaseEditors’:



View source version on businesswire.com:Korea Newswire distributes your news across every media channels through the 웃긴대학 송지효예쎄 industry’s 마징가TV Viewpress release distribution network



정선 카지노 운영시간,애니야동,웹툰365,후카다에이미판매사이트,남성 팬티,야부리,펜티판매쇼핑몰,후장자위,수유2동성인게임장,wSCNU,양평2동포커,화곡2동풀팟홀덤,단봉동홀덤대회,고18,마베이트,조또티비,앙기모띠넷,모바일섯다게임,베트남카지노호텔,한게임홀덤,정선카지노 중고차,베스트유머,만남,만남,만남,야충넷,초희넷,KIA[유창식],야덩,카사노바,카사노바,카사노바,홍콩여행중국,굿라이브티비,일본야동사이트,큐큐툰,지니로애느낌,남자속옷,케이티비,에그딜도추천,오마담,동소문동4가성인게임장,XFkp,신길1동포커,화곡3동풀팟홀덤,지가동홀덤대회,빨간비디오,캠스,딸잡고,꿀바넷,무료양귀비
전화번호 : 영업시간 :
홈페이지 : 위치정보 :

댓글목록

등록된 댓글이 없습니다.