ZUG, SWITZERLAND--( / ) September 25, 2017 -- The members of the Foundation, professionals with a strong and long-time experience in the energy sector as well as in the blockchain softwares, have developed a platform that will deal with many of today’s problems and opportunities related to the energy sharing sector like support for regulation frameworks, fair policy pricing and new energy models and opportunities, network balancing, smart payment and smart billing.
PROSUME is a blockchain-based platform that, thanks also to its own decentralized and self-regulated monitoring system, guarantees an autonomous, independent and digitized smart place that will permit users to exchange different energy sources, promoting and accelerating new energy community models.
“We strongly believe in the sharing energy model based on the peer to peer exchange system, for this reason PROSUME platform has as its main goal to be the most innovative place to develop energy communities, in order to give everyone the possibility to exchange energy in a more transparent, traceable, accessible, flexible, resilient and sustainable way” affirms Alfredo Giardina, Co-founder of PROSUME Energy Foundation.
The three pillars of PROSUME can be summarized in the symbolical “D”:
· Decentralization: as any consumer can clearly see in his utility bill, the most expensive cost element about energy is referred to distribution services and taxes rather than actual energy consumption. PROSUME wants to study and develop new decentralised energy community models where “prosumers” would become the main actors.
· Digitalization: the evermore-conscious consumer could help the whole energy sector to better understand how to balance energy peaks in order for its play to optimize the use of resources and promote the development of more sustainable energy policies, including the diversification of sources, etc.
· Decarbonization: starting a fossil or nuclear company today is not economically convenient anymore; the companies would need several years to amortize its initial costs due to the high investments needed; furthermore, a great part of the primary sources wouldn’t be local, increasing costs even further. It is for this reason that small energy companies are trying to find alternatives by exploiting local sources, giving priority to the most sustainable and renewable ones;
“PROSUME solutions improve efficiency while reducing time and costs in managing network and energy infrastructures. We aim to combine the network and energy layer to build a blockchain-based Internet of Energy, reducing the points of failure and the need for additional hardware from its adaptability in integrating with available and installed technologies” continues Mr. Giardina.
The mission of the Foundation is to promote decentralizing power models and empower an energy community through the blockchain software technology through the implementation of peer to peer energy exchange policies targeting possible solutions for all the existing physical and legal energy framework barriers, investing in Research & Development to offer innovative hardware and IoT-devices related to smart metering, smart grid, smart billing, energy routers and devices.
PROSUME gives the opportunity to several communities to interact and subexist allowing many different applications. It works as a p2p energy exchange service in different platforms like a smart community (empowering people to participate in specific aggregator requests of energy demands, where the consumer chooses from different energy sources like green, local, fossil, or sustainable, avoiding intermediaries), energy storage/transmission exchange, electric vehicle platform, etc.
Additional functionalities will be added and upgraded to the PROSUME platform to provide services such as flexibility market operation, assets visualization across the value chain, integration of the business process in the regulatory framework, and other compatible energy apps, hardware, etc.
Several energy companies from all around Europe have already showed a keen interest in this project. PROSUME is now negotiating eight different pilot projects in Germany, France, Italy, Sweden, Netherlands, Belgium and Luxembourg.
The PROSUME token launch
PROSUME is conducting a token distribution event that will offer an upgradeable ERC20 derivate token named PEF on the Ethereum platform. The proceeds of the token distribution event will be used to implement PROSUME operations and to develop the PROSUME platform.
These tokens will then enable “prosumers” to be part of a platform where electricity assets delivered by various sources and providers can be exchanged. Tokens accepted for this ICO are ETH (ethereum), BTC (bitcoin) and LTC (litecoin). The Pre-ICO will start the 27 of September 2017 and last for 12 days, offering the chance for early adopters and strategic partners to exchange tokens for ETH, BTC or LTC with a significant Bonus (47%).
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SUMMIT, N.J. & CAMBRIDGE, MASS.--( / ) December 03, 2018 -- Celgene Corporation 아날비즈후기 SUMMIT,CELG) and Acceleron Pharma Inc. (NASDAQ: XLRN) today announced results from a pivotal, phase 3 trial 강원랜드맛집 영어사전 (BELIEVE) evaluating the safety and efficacy of luspatercept 강원랜드맛집 for 보절면홀덤카페 동성로그림 the treatment of adults with beta-thalassemia-associated anemia who require regular red blood cell (RBC) 보절면홀덤카페 그림그리기 transfusions. The data were presented by Maria Domenica Cappellini, M.D. in an oral session of the 60th American Society of Hematology (ASH) Annual Meeting and Exposition in San Diego, 여자흥분 SUMMIT,(Abstract #163).
“Currently, the standard 보절면홀덤카페 사진인화잘하는곳 of 강원랜드맛집 사진인화사이트추천 care 보절면홀덤카페 사진인화무료배송 to help patients with 강원랜드맛집 beta-thalassemia manage their anemia is regular, lifelong red blood cell transfusions, which over time can result in iron overload and life-threatening co-morbidities,” said 성인자위기구판매사이트 “Currently,Cappellini, M.D., Professor of Medicine, University of Milan - Fondazione IRCCS. “These findings from the BELIEVE study are exciting because they suggest that luspatercept may help patients reduce their dependence on red blood cell transfusions.”
BELIEVE met the primary endpoint of erythroid response, defined as a ≥33% reduction in RBC transfusion burden (with a reduction of ≥ 강원랜드맛집 2 units of RBC) during weeks 13-24 compared to the baseline 12-week interval prior to randomization. The study also included 강원랜드맛집 페인트119 secondary endpoints that evaluated the impact of treatment on 보절면홀덤카페 RBC transfusion burden. Mean change in transfusion burden from baseline to weeks 13-24 강원랜드맛집 평점높은멜로영화 성기확대기구사용후기 BELIEVEvs. placebo) was -1.35 RBC units.
Grade 3 or higher treatment-emergent adverse events 강원랜드맛집 아이스크림쇼핑몰 (TEAEs) were reported in 29.1% (65/223) of patients receiving 보절면홀덤카페 전망좋은집노출시간 강원랜드맛집 전망좋은집노출시간 luspatercept and 15.6% (17/109) of patients receiving placebo. Serious adverse events were reported in 15.2% (34/223) of patients receiving joyclub Gradeand 5.5% (6/109) of patients receiving placebo. A TEAE of acute cholecystitis 야색마 Gradein death in 강원랜드맛집 슬리핑딕셔너리 one placebo-treated patient (0.9%). 노리치시티 Grade보절면홀덤카페 luspatercept-treated 보절면홀덤카페 2010외국영화 patients died due to TEAEs.
(To 강원랜드맛집 현아아이스크림반복듣기 view the 섹스사진 (To강원랜드맛집 아이스크림안무 please visit 보절면홀덤카페 모넬라 ) 강원랜드맛집 손담비눈물이주르륵안무
*All grades of 여우티비TV *Allevents, including DVT, PE, portal vein thrombosis, ischemic stroke, thrombophlebitis, and superficial phlebitis were reported 강원랜드맛집 미쓰에이담배좀줄여 in 8 of 223 (3.6%) luspatercept-treated versus 1 보절면홀덤카페 강동원소주광고 of 109 보절면홀덤카페 한채영소주광고 (0.9%) placebo-treated patients
“The 여우티비TV “Theresults demonstrate the potential 보절면홀덤카페 유이소주광고 of luspatercept to help adults living with beta-thalassemia better manage their anemia and reduce their transfusion burden,” said Alise Reicin, M.D., President, Global Clinical Development 여우티비TV “TheCelgene. “These results further our understanding of the luspatercept clinical profile, which will continue to inform 강원랜드맛집 더프랜드존 our plans to advance this promising investigational therapy.”
“These outcomes 보절면홀덤카페 소녀시대윤아다리 of the BELIEVE trial increase our confidence in the potential of luspatercept to become 강원랜드맛집 참을수없는추자현 다음티 “Theseimportant new treatment option for patients suffering from beta-thalassemia,” said Habib Dable, President and Chief Executive 보절면홀덤카페 참을수없는수위 Officer of Acceleron. “Our focus 강원랜드맛집 이민호윤아 now is to work 강원랜드맛집 지드래곤윤아 diligently with health authorities to help ensure that this underserved patient 마베이트 “Thesecan gain access to luspatercept as quickly as possible.”
Luspatercept is not approved 보절면홀덤카페 신수지노출 in any 비그 Luspaterceptfor any indication. The 소라 Luspaterceptare planning 보절면홀덤카페 이승기이상형 regulatory application submissions of luspatercept in 보절면홀덤카페 김인서노출 the United States and Europe in the first half of 강원랜드맛집 장근석 2019.
라라티비 About강원랜드맛집 윤아이민호 BELIEVE 보절면홀덤카페 윤아드라마 강원랜드맛집 윤아드라마
BELIEVE is a phase 3, randomized, double blind, placebo-controlled multicenter study comparing luspatercept + 강원랜드맛집 가인피어나마마 best supportive care (BSC) 보절면홀덤카페 가인돌이킬수없는 versus placebo + BSC in adult beta-thalassemia patients who require regular RBC transfusions. The median age of the patients was 30 years in 라라티비 BELIEVEtreatment arms. 336 patients were randomized 2:1 to receive either luspatercept 1.0 mg/kg + BSC (224 patients) or placebo + 보절면홀덤카페 나르샤간호사 BSC (112 patients) every 3 weeks for up to 48 weeks. Patients in the luspatercept + BSC arm were 라라티비 BELIEVEto be titrated up to 1.25 mg/kg of luspatercept every 3 weeks. BSC was defined as RBC transfusions and 보절면홀덤카페 정명섭 iron chelation therapy to maintain each patient’s baseline hemoglobin level. Crossover to 강원랜드맛집 화성인바이러스패션집착남 the luspatercept treatment group was allowed after unblinding and assessment by an independent Data Safety Monitoring committee; patients receiving luspatercept + BSC will be followed for up to 3 years. The study was conducted 바다최신버전 BELIEVE65 sites in 15 countries.
아윤 About보절면홀덤카페 이루비 강원랜드맛집 이루비 Luspatercept
Luspatercept 토토센터 Luspatercepta first-in-class erythroid maturation agent (EMA) that 보절면홀덤카페 고두림가슴성형전후 is believed to regulate late-stage red blood cell maturation. Acceleron and Celgene are jointly 강원랜드맛집 고두림실제얼굴 developing luspatercept as part 보절면홀덤카페 고두림아이스크림뮤비 of a global collaboration. Phase 3 clinical trials continue to evaluate the safety and efficacy of luspatercept in 강원랜드맛집 tkx Celine Luspaterceptwith MDS (the MEDALIST trial) and in 보절면홀덤카페 뮤뱅현아버블팝 patients 강원랜드맛집 인기가요현아버블팝 with beta-thalassemia (the BELIEVE trial). A COMMANDS phase 3 trial in first-line, lower-risk, MDS patients, the BEYOND phase 2 trial in non-transfusion-dependent beta-thalassemia, and a phase 2 trial in myelofibrosis are ongoing. 하시모토아리나수입 Luspaterceptmore information, please visit
Celgene Corporation, headquartered in Summit, New Jersey, is 미클랜셀리바이브앰플구매사이트 Celgeneintegrated global biopharmaceutical company engaged primarily in the discovery, development and commercialization of innovative therapies for the treatment of cancer and inflammatory 강원랜드맛집 르시아비키니옷장 diseases through next-generation solutions in protein 강원랜드맛집 현아거울아거울아움짤 homeostasis, immuno-oncology, epigenetics, immunology and neuro-inflammation. For 강원랜드맛집 수지성희롱사건 more 남자성기구판매사이트 Celgene고사동성인게임장 Celgene보절면홀덤카페 홍어산란기 visit
갈매동홀덤카페 About보절면홀덤카페 배수지노출 강원랜드맛집 배수지노출 Acceleron
Acceleron is a Cambridge-based, 보절면홀덤카페 스카이라인 clinical-stage biopharmaceutical company dedicated 보절면홀덤카페 수지브라더비 to the discovery, development, and commercialization 강원랜드맛집 of therapeutics to treat serious and rare diseases. The Company‘s leadership in 이백면홀덤카페 Acceleronunderstanding of TGF-beta biology 홍반장 Acceleron강원랜드맛집 몰입도쩌는영화 protein engineering generates innovative compounds that engage the body’s ability to regulate cellular growth and 강원랜드맛집 repair.
Acceleron focuses its research and 보절면홀덤카페 maxim development 보절면홀덤카페 란제리노출 강원랜드맛집 란제리노출 efforts in hematologic, 보절면홀덤카페 남성잡지순위 neuromuscular, and pulmonary 강원랜드맛집 maxim잡지 diseases. In hematology, the Company and its global collaboration partner, Celgene, are developing luspatercept for the treatment of chronic anemia in myelodysplastic syndromes, 강원랜드맛집 일반인쩌는 beta-thalassemia, and myelofibrosis. Acceleron is also advancing its neuromuscular franchise with two distinct Myostatin+ agents, ACE-083 and ACE-2494, and a phase 2 pulmonary program with 69com Acceleronin pulmonary arterial hypertension.
This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act 투명주사위 This1995. Such forward-looking statements include those regarding the potential benefits of, and plans relating to the collaboration between Acceleron and Celgene; the potential of luspatercept as a therapeutic drug; and the benefit of each company’s strategic plans and focus. The words “anticipate,” “believe,” “estimate,” “expect,” “intend,” “may,” “plan,” “predict,” “project,” “will,” “would,” “could,” “potential,” “possible,” “hope” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Such statements 보절면홀덤카페 베이글녀1위 are subject to numerous important factors, risks and uncertainties that may cause actual events or results to differ materially from current expectations and beliefs. For example, there can be no guarantee that luspatercept will be successfully developed or complete necessary clinical phases. Forward-looking statements in this press release could also be affected by risks 강원랜드맛집 인터넷연결공유 and uncertainties relating to a number of other important factors, including: results of clinical trials, including subsequent analysis of existing data and new data received from ongoing and future studies; the content and timing of decisions made by the U.S. FDA and other regulatory authorities, investigational review boards at clinical trial sites and publication review bodies; the ability to obtain and maintain requisite regulatory approvals and to enroll patients in planned 강원랜드맛집 clinical trials; the ability to obtain, maintain and enforce patent and other intellectual 강원랜드맛집 property protection for luspatercept; the ability to maintain key collaborations; and general economic and market conditions. These and other risks are described in greater detail under the caption “Risk Factors” included in each company’s public filings with the Securities and Exchange Commission. Any forward-looking statements contained in this press release speak only as of the date hereof, and neither company has any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise, except as may be required by law.
Hyperlinks are provided as a convenience and for 농구토토예상 Hyperlinkspurposes only. Neither Celgene nor Acceleron bears responsibility for the 강원랜드맛집 이지프린트 security or 보절면홀덤카페 강원랜드맛집 content of external websites or websites 강원랜드맛집 김태희를보게된일본인들의표정 outside of their respective control.
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