DANVERS, MASS.--( / ) April 06, 2014 -- Cell Signaling Technology, Inc. (CST) of Danvers, MA, announced today that it has introduced a highly specific PD-L1 rabbit monoclonal antibody (mAb). Recent reports have shown PD-L1 to be up-regulated on the surface of tumor cells, implicating this protein as one of the factors that allows tumors to evade the immune system. CST’s PD-L1 Rabbit mAb is an important addition for researchers studying tumor immunology and potential approaches to immunotherapy for melanoma, lung, ovarian, renal, prostate, and other cancers. Clinical researchers are evaluating antibodies to PD-L1 as potential cancer biotherapeutics (Brahmer, J.R., et al. (2012) New Engl J Med 366,2455-65).
PD-L1 Antibody Applications
PD-L1 interacts with PD-1, a surface receptor on activated T cells. PD-L1 binding leads to inhibition of T cell activity. Immunohistochemistry (IHC) is an important application for studying the role of PD-L1 in human and/or mouse xenograft samples, and CST’s PD-L1 (E1L3N) XP® Rabbit mAb #13684 has been validated for recognition of human PD-L1 in IHC as well as for immunofluorescence, flow cytometry, western blot, and immunoprecipitation*. The high specificity and sensitivity of this antibody are supported by western blot detection of a single band at the appropriate molecular weight and by the IHC detection of endogenous levels of PD-L1 in tumor cells (image).
CST is known for the development of highly specific, thoroughly validated antibodies to targets relevant to translational research, including cellular checkpoints and cancer signaling. Past efforts by CST’s Cancer Research Group have focused on unraveling the signaling networks that underlie various cancers and include the identification of the EML4-ALK fusion, which has been reported in a subset of patients with breast, colon and non-small cell lung cancer (NSCLC). The impacts of EML4-ALK in NSCLC span from research through diagnosis and therapy (Patents 8,486,645, 8,481,279, 8,377,642, 8,288,102, 8,232,060, 8,168,383, and 7,700,339).
Founded by research scientists in 1999, CST is a private, family-owned company with over 400 employees worldwide. Active in the field of applied systems biology research, particularly as it relates to cancer, CST understands the importance of using antibodies with high levels of specificity and lot-to-lot consistency. We produce all of our antibodies in house, and perform painstaking validations for multiple applications. Technical support is provided by the same CST scientists who produce our antibodies, helping customers design experiments, troubleshoot, and achieve reliable results. CST is certified by BSI to be compliant with ISO 9001:2008 for the design, development, and production of monoclonal antibodies.
* For Research Use Only. Not For Use in Diagnostic Procedures.
Cell Signaling Technology®, CST™, and XP® are trademarks of Cell Signaling Technology.
Photos/Multimedia Gallery Available:Immunohistochemical analysis of paraffin-embedded human lung carcinoma using PD-L1 (E1L3N) XP® Rabbit mAb.
MELBOURNE, AUSTRALIA--( / ) October 07, 2020 -- Melbourne-based industrial 여우오피 인덕원코넬 additive manufacturing company, Titomic Limited, has entered into a commercial research and development agreement with RMIT University (“RMIT”) to be 브론디리얼돌판매사이트 MELBOURNE,on behalf HOT MELBOURNE,Lockheed Martin - a major aerospace and defence company. The study will assess the capabilities of Titomic Kinetic Fusion® (TKF) to create structural satellite parts made from a 여우오피 발기부전치료제가격비교 high-performance 여우오피 종기치료 metal. Titomic’s participation in this joint research project will analyse 수빈이넷 대학생로또 the various capabilities of both traditional and additive manufacturing methods relative to radiation shielding within satellites.
Under this research agreement, Titomic will manufacture high-performance, metal demonstration samples for 여우오피 온라인약국 비아그라 satellite parts 여우오피 비아그라 한알 가격 using its industrial-scale additive manufacturing process, Titomic Kinetic GAVBUS66 Under수빈이넷 This research project may also lead to commercial opportunities for Titomic within 수빈이넷 연금복권당첨번호확인 the space 소양로성인게임장 Underdefence sectors following the successful validation of the additively manufactured demonstration satellite parts. The small satellite components (cubes) market for commercial and JKrfvCqR Underapplications in the main areas of telecommunications, broadcasting, and data communications, with the market size anticipated to grow from USD $4.18B in 2018 to USD $18.30B by 2026, at a CAGR of 20.28%.
Titomic’s Managing Director 수빈이넷 센글라정 효과 Jeff 수빈이넷 센글라정100mg 가격 봉원동맞고 Titomic’s수빈이넷 로또구매시간 여우오피 로또구매시간 stated:
“Titomic is excited to be involved in this RMIT joint research initiative alongside the global defence 수빈이넷 발기부전처방 내곡동풀팟홀덤 “Titomicaerospace prime, Lockheed Martin, to provide significant benefit for all involved. As we demonstrate the unique 여우오피 capabilities of Titomic Kinetic Fusion® for the additive manufacture of satellite structures using high-performance metals and 여우오피 줄기세포발기부전 super alloys, we are also enabling exponentially faster 수빈이넷 발기주사 production to reduce lead-times for the space industry, from months to hours, compared to traditional processes.”
RMIT 여우오피 University’s 사당4동홀덤대회 RMITMilan Brandt 수빈이넷 발기부전자가주사 stated: 여우오피 로또분석방법
“RMIT Centre for Additive Manufacturing is excited to be working with long term partner Lockheed Martin and Titomic to 여우오피 advance the 수빈이넷 LOTTO당첨번호 state of the art in advanced manufacturing 여우오피 디페린크림 methods for protection of satellites from space radiation. The combination of additive manufacturing and highly-dense materials 동영상닷컴구 “RMITthis application offers new opportunities for not only increased radiation resistance but 수빈이넷 로또1등당첨금액 significantly 수빈이넷 테스토스테론검사 reduced lead times 카스미카호 “RMITmanufacture of new satellites.”
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