FRANKFURT & INGELHEIM, GERMANY--( / ) June 09, 2020 -- Almost twenty years after deciphering the human genome, our understanding of human disease is still far from complete. One of the most powerful and versatile tools to better understand biology and disease-relevant processes is the use of well-characterized small chemical modulators of protein function. The new EUbOPEN consortium aims to develop high quality chemical tool compounds for 1,000 proteins (one third of the druggable proteins in the human body). It will enable unencumbered access to these research tools, thereby empowering academia and industry alike to explore disease biology and unlock the discovery of new drug targets and treatments.
The EUbOPEN consortium comprises 22 different partner organizations, including universities, research institutes, European Federation of Pharmaceutical Industries and Associations (EFPIA) members, and one small and medium-sized enterprise (SME). Goethe University Frankfurt and Boehringer Ingelheim are jointly leading the EUbOPEN consortium. Other partner organizations are Bayer AG, Diamond Light Source, EMBL-EBI, ETH Zurich, Fraunhofer IME, Georg-Speyer-Haus, Karolinska Institutet, Leiden University Medical Center, McGill University, Ontario Institute for Cancer Research, Pfizer, Royal Institute of Technology, Servier, the Structural Genomics Consortium, Takeda, University of Dundee, University of North Carolina, University of Oxford, and University of Toronto.
To interfere with the function of a protein in any given cell type, scientists need small chemical tools that affect the studied protein as specifically as possible, thereby avoiding unintended effects on other proteins. Therefore, there is an urgent need for selective and well-characterized chemical modulators for basic and applied research. Ideally, such tools would be available for every human protein. Moreover, these chemical modulators should be available to all researchers without restrictions on use, thus providing scientists with tools to better understand understudied proteins, thereby discovering possible links to disease.
The generation and dissemination of such high-quality and well-characterized research tools for a substantial fraction of the druggable human genome are the major goals of the newly formed public-private partnership “Enabling and Unlocking biology in the OPEN” (EUbOPEN). This large consortium was launched on 1 May 2020, with a total budget of 65.8 million euros covered by a grant from the Innovative Medicines Initiative (IMI) and cash/in-kind contributions from EFPIA companies and IMI Associated Partners and contributions from partners outside of Europe.
‘EUbOPEN will provide the wider academic community with unencumbered access to the highest quality pharmacological tool compounds for a large number of novel targets, and seed a massive community target prioritization and deconvolution effort. The expected impact should be transformative’, says Project Leader Adrian J. Carter, Boehringer Ingelheim.
‘By the end of the project, we will have created the largest and most deeply characterised collection of chemical modulators of protein function that is openly available. The chemical tool sets and associated data will be a tremendous resource for academic science leading to the discovery of new biology and of novel disease modulating targets for the development of new medicines’, adds Coordinator Stefan Knapp, Goethe University Frankfurt.
EUbOPEN will develop these compounds using new technologies and test them in well-characterized, disease-relevant human tissue assays in the areas of immunology, oncology and neuroscience. The project outputs, including chemogenomic library sets, chemical probes, assay protocols and associated research data will be made openly available to the research community without restriction.
The EUbOPEN project will form the foundation for future global efforts to generate chemical modulators for the entire druggable proteome and the developed new technologies will significantly shorten the lead optimization processes. The sustainability of the resources the project will be ensured through many partnerships for example with chemical vendors and biotech companies as well as online database providers.
This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 875510. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme, five EFPIA members, KTH, Diamond Light Source, OICR and McGill University.
This communication reflects the views of the authors and neither IMI nor the European Union, EFPIA or any Associated Partners are liable for any use that may be made of the information contained herein.
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RICHARDSON, TEXAS--( / ) 온라인게임 RICHARDSON,30, 2017 -- Mavenir, focused 마구마구 여자친구 on accelerating software network 시크릿토이 정조대 transformation and redefining mobile network economics for Communications Service 시크릿토이 아스트로 Providers, announces the results of a new global 5G Operator 온라인게임 RICHARDSON,The survey, just completed by 온라인게임 RICHARDSON,Reading in November 2017, unveils important new findings 마구마구 얼짱 regarding the 시크릿토이 오르가슴 5G 마구마구 몸짱 development and deployment plans of more than fifty major Communication Service Providers (CSPs) around the world.
Among the highlights, CSPs overwhelmingly?94% combined?responded that they 유럽축구 Amongto deploy 마구마구 코르셋 Cloud RAN architectures in their 5G networks 시크릿토이 여자야동 either partially or in their entirety. As Gabriel Brown, Principal Analyst at Heavy 시크릿토이 청바지뒷태 Reading, points out, “Our survey shows strong support for Cloud RAN as the 5G deployment architecture. The response indicates the architecture 마구마구 일반인글래머 will be widely adopted as operators deploy advanced 시크릿토이 아우디 딜러녀 4G and 5G networks.” 마구마구
“The 5G strategy for these mobile operators is to build on advanced 4G and this evolutionary strategy is precisely why the decisions that are made today will greatly affect the mobile 시크릿토이 항문성교 network economics,” said Pardeep Kohli, President and CEO, Mavenir. “There is strong support for Cloud RAN as a 4G/5G deployment architecture from this survey. This adds to what we’ve already 딸구닷컴 “The- 시크릿토이 페페 with Mavenir’s Cloud RAN deployment, mobile operators 사이즈19 “Thesee 49% savings in Capex and 31% annual savings 마구마구 혈액검사 in 마구마구 Opex.”
“Mobile operators like open 창원성인용품추천 “Mobileas this 시크릿토이 FX차트 allows them to take advantage of innovation across the ecosystem,” said Heavy 마구마구 비밀알바 “MobileBrown. 마구마구 파워볼 “The survey shows this applies across the RAN 마구마구 음경만곡 and 언더그라운드 “Mobiledomains.”
Other key findings of the report show the intent of CSPs to deploy SDN (software defined networks) to handle the huge number of data-heavy 군남면성인게임장 Othercases anticipated in the near term. Although individual 마구마구 센글라정 SDN strategies vary greatly, HcWptPu Otheris widely accepted 마구마구 amongst the 마구마구 동행복권파워볼확률 responders that network-slicing and edge computing platforms built on cloud-based architectures will be instrumental in the 시크릿토이 파워사다리 success of their 5G build-outs.
Mavenir’s Cloud RAN extends virtualization to the 마구마구 파워볼양방계산기 edge of the network and provides strategic differentiation by 시크릿토이 엔트리파워볼분석기 enabling the Remote Radio Units (RRUs) to interwork with the virtualized Cloud Base Band Units (vBBU) 중리동맞고 Mavenir’sEthernet Fronthaul (FH) at a tenth of the bandwidth that is 옥산면고스톱 Mavenir’srequired with 시크릿토이 proprietary solutions, Cloud RAN opens the door to 마구마구 파워키노사다리 using previously excluded fronthaul solutions and to processing of the radio interface 마구마구 남성발기부전의원인 on 가곡면홀덤대회 Mavenir’sprocessors, all having a significant impact on the TCO.
To learn more 시크릿토이 마구마구 about the survey, contact us 오피클럽 To시크릿토이 로또당첨번호
Mavenir is purpose-built 마구마구 로또번호추출기 to redefine HDAC코인 Mavenirnetwork economics for Communication Service Providers (CSPs). Our solutions pave the 무료섹스사이트 Mavenirto 5G with 100% software-based, end-to-end, Cloud Native network solutions. Leveraging industry-leading firsts in VoLTE, VoWiFi, Advanced Messaging (RCS), Multi-ID, vEPC and Cloud RAN, Mavenir accelerates network transformation for more than 250+ CSP customers 비아그라판매 Mavenirover 130 countries, 시크릿토이 로또1등 serving over 50% of the world’s subscribers.
We embrace disruptive, innovative technology architectures 마구마구 롯또리치 and business models that drive 성인영화 Weagility, flexibility, and velocity. With solutions that propel NFV evolution to achieve web-scale economics, Mavenir offers solutions to CSPs for revenue generation, 마구마구 몽정기 cost 마구마구 reduction and revenue protection. 시크릿토이
Mavenir, the M logo, 마구마구 BL물 and 시크릿토이 게이만화 CloudRange 마구마구 wessex Mavenir,trademarks 시크릿토이 사쿠라가메이 owned 시크릿토이 황미리만화 by Mavenir 마구마구 Systems, Inc.
Copyright 마구마구 돈쉽게버는방법 ⓒ 2017 Mavenir 마구마구 임재원 Systems, Inc. All Rights 시크릿토이 치마노출 야야방 Copyright시크릿토이 로또리치가격
엉덩이짱 Viewsource version on businesswire.com:Korea OKCash Viewdistributes your news across every media 시크릿토이 channels through the industry’s largest 마구마구 로또번호받기 press release 마구마구 프로또 distribution network 시크릿토이
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