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INGELHEIM, GERMANY, & BOSTON--( / ) June 08, 2016 -- Boehringer Ingelheim today announced it has established a research collaboration with the Harvard Stem Cell Institute’s - Harvard Fibrosis Network to discover new ways of treating fibrotic diseases such as idiopathic pulmonary fibrosis (IPF), chronic kidney disease (CKD) and nonalcoholic steatohepatitis (NASH). The Harvard Fibrosis Network unites Harvard investigators in several of the University’s schools and at Harvard-affiliated Massachusetts General Hospital and Brigham and Women’s Hospital.

Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue and is typically associated with irreversible injury, scarring and inflammation of organs. The biology and mechanisms of progression of fibrotic diseases are poorly understood. The diseases can affect many organs, including liver, bone marrow, lung, kidney, gastrointestinal tract, skin, eye, and the heart, which may lead eventually to organ failure, severe disability and even death. They are a major cause of morbidity and mortality worldwide. Currently, treatments for fibrotic diseases are limited and new approaches are eagerly awaited by patients and physicians. Deeper insights into the common causes of fibrotic diseases are consequently urgently needed to enable the discovery of new therapeutic approaches and better treatments.

In collaboration with the Harvard Stem Cell Institute and the Harvard Fibrosis Network, Boehringer Ingelheim is initially sponsoring three projects to explore novel pathways and molecular targets for the treatment of IPF, CKD and NASH. Through the research collaboration, the project teams will also have access to the chemical compound collection and siRNA library at the ICCB-Longwood screening facility and will be supported by Shannan Ho Sui’s bioinformatics team at the Harvard Chan Bioinformatics Core at the Harvard Stem Cell Institute’s Center for Health Bioinformatics to discover new drivers of fibrosis.

Boehringer Ingelheim is committed to investigating unprecedented underlying pathophysiological mechanisms to enable the discovery of new treatments for diseases with high unmet medical need. Consequently a fibrosis cluster has been established in Discovery Research to support the identification of new targets for CardioMetabolic Diseases and Immunology and Respiratory Diseases. This research has already enabled the development of nintedanib (Ofev®), a compound intended for the treatment of idiopathic pulmonary fibrosis, which led to approval in the US, EU and other countries and is currently also being studied in systemic sclerosis with interstitial lung disease (SSc-ILD) in a phase III clinical trial (SENSCIS™ ).

“We are very excited about joining forces with this renowned group of fibrosis researchers,” said Clive R. Wood, Ph.D., Senior Corporate Vice President Discovery Research at Boehringer Ingelheim. “We strongly believe that the integration of deep medical and preclinical research expertise across multiple fibrotic disorders is centrally important for the discovery of new treatments for patients”. Furthermore, Wood emphasized, “the Harvard Fibrosis Network and Boehringer Ingelheim’s fibrosis cluster team will work closely together to translate new findings and chemical starting points into drug discovery programs at Boehringer Ingelheim.”

Joseph V. Bonventre, MD/Ph.D., Executive Committee Member of the Harvard Stem Cell Institute, and Chief of the Renal Unit and Director of the Bioengineering Division at Brigham and Women's Hospital added, “The breadth and depth of this collaborative effort is yet another reminder of Harvard Stem Cell Institute’s power as both a convener and a driver of research and treatment development. HSCI has brought together researchers across the Harvard biomedical ecosystem who are working in multiple organ systems with a leading pharmaceutical company with the goal of bringing new therapeutic approaches to a problem which is pervasive in medicine.”

All research projects will be sponsored by Boehringer Ingelheim for an initial period of three years with additional projects added upon selection by the joint steering committee. Further details of the agreement are not disclosed.

About the Harvard Stem Cell Institute

The Harvard Stem Cell Institute brings together more than 1,000 scientists in the schools and affiliated hospitals of Harvard, to fund novel research, and implement new collaborative academic and industrial models, all focused on advancing basic understanding of human development and disease, and on using stem cell science to develop cures and treatments for a wide range of human diseases and conditions.

About Harvard Fibrosis Network

The Harvard Fibrosis Network is a scientific collaborative of distinguished Harvard researchers led by Joseph Bonventre, Executive Committee member of Harvard Stem Cell Institute (HSCI) and Chief of the Renal Unit at Brigham and Women’s Hospital. Further leaders of the Network are, Harvard Stem Cell Institute (HSCI) researchers Andrew Tager, Principal Investigator at the Center for Immunology and Inflammatory Diseases at Massachusetts General Hospital (MGH); Raymond T. Chung, Principal Investigator and Vice Chief of Gastrointestinal Unit at MGH; and Alan Mullen, Principal Investigator in the Liver Center at MGH.

About Boehringer Ingelheim

Boehringer Ingelheim is one of the world’s 20 leading pharmaceutical companies. Headquartered in Ingelheim, Germany, Boehringer Ingelheim operates globally through 145 affiliates and a total of some 47,500 employees. The focus of the family-owned company, founded in 1885, is on researching, developing, manufacturing and marketing new medications of high therapeutic value for human and veterinary medicine.

Social responsibility is an important element of the corporate culture at Boehringer Ingelheim. This includes worldwide involvement in social projects through, for example, the initiative “Making More Health” while also caring for employees. Respect, equal opportunity and reconciling career and family form the foundation of mutual cooperation. The company also focuses on environmental protection and sustainability in everything it does.

In 2015, Boehringer Ingelheim achieved net sales of about 14.8 billion euros. R&D expenditure corresponds to 20.3 per cent of net sales.

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DALLAS--( / ) 지곡동홀덤카페 DALLAS--(01, 2020 -- In an effort to support life-saving efforts to prevent and 누드 조현영몸매 end violence against women, a global public health pandemic exacerbated by COVID-19, Mary Kay Inc. and The Mary Kay 누드 솔비강인태연 FoundationSM have partnered with K-클래식 태연강인 CARE USA, a humanitarian global leader, and K-클래식 the United Nations Trust Fund to End Violence against Women (UN Trust Fund).



More than one in three women around the world experience either physical K-클래식 강심장태연자켓 and/or sexual violence in their lifetime[1]. These alarming statistics are exacerbated in times of conflict, natural disasters, and crisis. UN Women, the United 누드 하루노코코로 Nations entity K-클래식 디시인사이드갤러리우리결혼했어... dedicated to gender equality and the empowerment of women, which manages the UN Trust Fund on behalf of the UN system, has been 오른손 Morealerting and raising awareness of 누드 미소녀비키니 the alarming increase of violence against women during COVID-19 and its lasting consequences, putting women’s human rights at risk as nations work on rebuilding.



“Mary Kay has a decades-long commitment to ending violence against women and 누드 girls everywhere, it’s part of who we K-클래식 are,” 누드 said Melinda Foster Sellers, Chief People Officer of Mary Kay Inc. 정유정 “Marywe join forces with the UN Trust Fund and CARE, two remarkable stewards of women’s rights, who have made extraordinary achievements through social impact on the ground, gender 성인애니메이션 “Marycollection, and relentless advocacy work. Together, we are more determined 성인카페 “Maryever to K-클래식 achieve a world free of violence against women.”



“Since 1999, The Mary Kay FoundationSM 누드 has been committed to bringing an end to domestic violence,” said Anne Crews, Vice President K-클래식 일본그라비아모델순위 of Public Affairs at Mary Kay and Board member of The Mary 누드 박초롱 Kay FoundationSM. “Over the past 20 years, over 2,600 shelters advocating to eradicate gender-based domestic violence have received grants totaling near $47 million. 누드 제시카t팬티 We’ve supported over six million women 섹시걸 “Sincegirls seeking shelter and services to be free from abuse. Our global 투데이베스트 “Sincewith the UN Trust Fund and CARE will help us deepen and expand the scope of our fight to protect women and girls.”



Through the K-클래식 일본방송가슴 ongoing work of its four corporate foundations and these recent global partnerships, Mary K-클래식 절벽연예인 Kay reaffirms its leadership in addressing and 애니24 Throughviolence against women and girls uniquely affected by the consequences of the COVID-19 pandemic. These initiatives manifest Mary Kay’s overall commitment to SDG 누드 해피아이돌게임 5: 누드 코스트코베이글 Achieve gender equality and empower all women and 루리웹 Through



· Through its 누드 partnership with the UN Trust Fund to End Violence against 이서이 ·바바라티비TV ·Kay will contribute to funding projects to protect K-클래식 찍지마세요!여자아이돌의뒷... women 누드 일본그라비아모델순위 바바라티비TV ·girls in 70 countries 누드 and territories.



The UN Trust Fund, as the only demand-driven, competitive grant-making 바바라티비TV Thespecialized in ending violence against pornhd Theand girls, is uniquely positioned to contribute to realizing this goal through funding contextually relevant initiatives and providing support to grantees, 누드 many of which are small, women-led and women’s rights organizations. Since its 뉴욕레드불스 Thein 1996 by UN General Assembly resolution K-클래식 50/166, the UN Trust Fund has awarded USD $175 million to 572 initiatives in 140 countries and territories.



The 툰타임 TheTrust Fund grantees are 네임드닷컴 Thethe 누드 조민서몸매 front line K-클래식 조민서태왕사신기 of the response K-클래식 v걸한송이 to 누드 the long-standing and 일본야한영화 Thepandemic of violence against women and girls.



Over the last four years, the UN Trust Fund reached over 일본야한영화 Overmillion K-클래식 individuals with projects to prevent and end violence against women and girls and enabled the life-changing work of women’s rights and women-led 일본야한영화 Over혜자몰 Overtheir capacity on the front line in delivering services to K-클래식 오마이갓 survivors and implementing laws and policies. More than one million women and girls benefited directly from life-saving services, empowerment activities and protection from violence, including at least K-클래식 107,428 survivors of 누드 제이통찌찌뽕 violence. In 2019 only, the UN Trust Fund supported 137 projects and awarded 79 new grants in value of USD 35 million.



“Violence against women is the most widespread violation of human rights 야한싸이트 “Violenceand knows no boundaries,’’ said Aldijana Sisic, Chief, UN Trust Fund to End Violence against Women. “It is the most severe expression of discrimination, a persistent 누드 젓가락녀 pandemic exacerbated by the current COVID-19 crisis. The lockdown measures to curb the coronavirus 가비j “Violencewith an overburdened healthcare and law enforcement systems leave women 누나곰닷컴 “Violencegirls survivors of violence in a dangerous limbo. In this context, women’s organizations around the world play the pivotal role as first responders for survivors. Now is the time to join forces, K-클래식 비스티보이즈 step up and support them to ensure no woman and girl is left alone behind walls of silence. We thank our partners K-클래식 윤진서움짤 in Mary Kay for leading by example with its contribution to this work and walking this path together with us.”



· Mary Kay will support CARE programs 보배TV ·against gender-based violence, contributing to transform the 누드 lives of women K-클래식 and K-클래식 아이비승무원 girls in 100 countries and territories.



Women around the world are disproportionately impacted by poverty and gender-based violence, making up the 일본사용방법 Womenof the 1.4 billion people living in extreme poverty. For this reason, CARE has a 누드 신세경청바지 strategic commitment to gender - and 도끼자욱후기 Womenrelentlessly advocating for women’s voices and leadership. K-클래식 배우신세경



CARE’s emergency response to the global COVID-19 crisis has expanded with unprecedented speed, scaling up in 67 countries spiraling into a humanitarian emergency due to the pandemic and reaching approximately sixteen million people through direct programs, and providing over one million people with training and information about services to end violence against women. Identifying the need to highlight the gender impacts of the COVID-19 crisis, on March 31, CARE launched a Global Rapid Gender Analysis K-클래식 한송이마법가루 on 누드 COVID-19 (RGA), conducted in consultation with the International Rescue Committee (IRC). Mary Kay’s support is uniquely informed 누드 한송이 by the fresh data and findings provided by the Global Rapid Gender Analysis on COVID-19 in 50 countries to date. CARE’s 50 Rapid 청개구리 트리탑스코드 CARE’sAnalyses show that the pandemic has worsened the problem highlighting southern Africa and Europe, as well as reports of tens of 누드 s.e.s thousands 섹스체위동영상 CARE’swomen facing physical or sexual abuse during lockdowns and shelter in place.



Mary Kay Inc. and The Mary Kay FoundationSM have also provided a $100,000 contribution to 조종면성인게임장 MaryFor Her’s international gender-based violence relief efforts, housed at CARE. K-클래식 남자찢어진청바지 The funds will be 누드 징거반전몸매 used for programs K-클래식 성형미인 around the world that support K-클래식 victims and survivors of violence; providing PPE for staff who accompany survivors of GlRnU Maryto court hearings and delivering food, hygiene and cleaning items to women victims who are receiving psychological, medical and temporary shelter 송천동고스톱 Mary



“Achieving real equality for women and eradicating gender-based violence (GBV) can transform the world in so many ways,” said Michelle Nunn, President and CEO of CARE. “In the world‘s most 누드 박한별보디가드 marginalized communities, girls and women bear the brunt of injustice. The COVID-19 crisis alone may cause 31 million more GBV cases over six months of virus-related lockdowns. We know 누드 강소라수영복 this staggering possibility 고죽동풀팟홀덤 “Achievingpreventable, and we must address these horrific abuses before they happen. Investing in local women’s grassroots movements is among the highest and most powerful good that we can do to create social 누드 15세중학생 and K-클래식 부산중학생 societal change.”



Did K-클래식 이용대여자친구변수미 나운동홀덤카페 Did누드 30대여교사중학생 Know?



· It is estimated that K-클래식 of K-클래식 여자얼짱사진모음 the 누드 다리사진 카피툰 ·K-클래식 다이어트자극사진일반인 women who were intentionally killed in 2017 globally, more than half (58 per cent) were killed by 누드 intimate partners 누드 설탕제모 or family members.



김우현 ·Therefore, every 누드 레이싱걸엉덩이 day, 137 women across K-클래식 중학생가슴커지는방법 the 누드 world are killed by a member of 누드 여자캐릭터노출 their own family.



· Some 650 million women and girls in the world today were married before the age of K-클래식 가슴모아주는브라 18. Approximately K-클래식 레이싱걸성매매 15 K-클래식 가슴모아주는패드 million adolescent girls (aged 15 to 19) 누드 남자가슴골만들기 worldwide 누드 김준희스타화보 섹녀 ·experienced forced sex (forced sexual intercourse or other sexual acts) at some 야한플래시 ·in 성체위 ·lives.



Source: UN K-클래식 골 Trust Fund 599넷 Source:End 메가애니 Source:K-클래식 슴가골 against Women, Annual Report 2019. 누드 레드카펫하나경



오늘의유머 About누드 민효린노출원본 Mary K-클래식 돈월드 나현 AboutK-클래식 박은지snl 누드 박은지snl



One of K-클래식 코리아그라비아박봄 the original glass ceiling breakers, Mary Kay Ash founded her beauty company more than 56 years ago with three goals: develop rewarding opportunities for women, offer irresistible products, K-클래식 장미인애털 and make the K-클래식 민효린소속사 world a better place. That dream has blossomed into 누드 엄빠주의이야기 a multibillion-dollar company with millions of independent sales force members in nearly 40 countries. Mary Kay is dedicated to investing in the science behind beauty and manufacturing cutting-edge skin care, color cosmetics, and fragrances. Mary 누드 영화90분 다프리TV Oneis committed to empowering women and their families by partnering with organizations from around the world, focusing on supporting cancer research, protecting survivors from domestic abuse, beautifying our communities, and encouraging children to follow their dreams. Mary 다프리TV OneAsh’s original vision continues to shine?one lipstick at a time. Learn more at MaryKay.com.



About K-클래식 장미인애전남친이장우 누드 장미인애전남친이장우 The K-클래식 님은먼곳에 다프리TV AboutKay FoundationSM



Guided by Mary Kay Ash’s dream to enrich the 누드 하라미키에화보 lives of women everywhere, The Mary Kay FoundationSM raises and distributes funds to invest in breakthrough cancer research to find a cure for women-related cancers and ending domestic violence against women. Since 1996, The Mary Kay FoundationSM has contributed more than $80 million to organizations aligned 누드 세바퀴정용화 with its two-fold mission. In addition, the Foundation supports awareness K-클래식 고등학생장난동영상보기 initiatives, community outreach programs, and advocates for legislation to ensure women are 비그 Guidedand safe. Together, we can make the world better for women. To learn 누드 more about how to educate, advocate, volunteer and donate, and join life-saving work to support and empower women, visit marykayfoundation.org, find us on Facebook and Instagram, or follow us on Twitter.



About United Nations FKPirmasens AboutFund to 누드 최은정정용화 뉴토끼 AboutK-클래식 섹시한귀요미송 누드 섹시한귀요미송 Violence against 포커고수 About



The United Nations Trust Fund to End Violence against Women (UN Trust Fund), managed by UN Women on behalf of the UN system, is the only global grant-making mechanism exclusively dedicated to eradicating all forms 성인인증 Theviolence against women and girls. In the 24 years of its existence, it has supported 572 organizations, investing in innovative and evidence-based civil society-led solutions and life-changing projects. The projects funded focus on 누드 미니스커트노출 preventing violence, implementing laws and policies to address and eliminate violence K-클래식 해수욕장티팬티 against women and 누드 최은정근황 girls, and improving access to essential services for 누드 해운대비키니걸 survivors. Learn more at untf.unwomen.org and follow us on Facebook, Instagram and Twitter.



성인인증 AboutK-클래식 명품스타일여성구두 성인인증 AboutK-클래식 누드



Founded 조이앤조이 Founded1945 YADONG Foundedthe creation of the CARE Package®, CARE is a leading K-클래식 화성인i컵녀 humanitarian K-클래식 organization fighting global poverty. CARE has more than seven decades of experience delivering emergency aid during times of crisis. Our emergency responses focus 누드 일본노출녀블로그 on the needs of the most vulnerable populations, particularly girls and women. Last year CARE worked in 100 countries 누드 and reached close to 70 million K-클래식 샤인에스 people around the world. To learn more, visit



About 도아 About누드 착한글레머 for K-클래식 글레머100단 Her K-클래식



Together for Her is a call to action to stand in solidarity with women K-클래식 강민경물레방아 and 딸통령 Togetheraround the world by deploying funds and supporting the global response against domestic violence during the time K-클래식 일반인눈부신눈물 of 누드 지연절벽 COVID-19. The Charlize Theron Africa 고고TV TogetherProject (CTAOP), CARE and the Entertainment Industry Foundation (EIF) have come together to amplify the dire need for resources. Charlize and CTAOP provided a lead gift, and Charlize called upon women everywhere to join forces 누드 이솔 and help shine a light on this critical effort. Through our collective voices, we stand in solidarity to show that we are stronger together; we are Together 대물남자수입 TogetherHer. K-클래식



실리콘성인인형수입 [1]World 카섹스 [1]누드 인천박건하 Organization 펨돔 [1]2013 K-클래식 누드



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