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WILLIAMSVILLE, N.Y.--( / ) April 10, 2019 -- 22nd Century Group, Inc. (NYSE American: XXII), a plant biotechnology company that is a leader in tobacco harm reduction, Very Low Nicotine Content tobacco, and hemp/cannabis research, announced today that the Company has entered into a worldwide strategic research and development agreement with KeyGene, , a global leader in plant research involving high-value genetic traits and increased crop yields. This exclusive, worldwide collaboration will focus on developing hemp/cannabis plants with exceptional cannabinoid profiles for medical and therapeutic use among other applications.
Cannabinoids are naturally occurring compounds found in hemp and in cannabis that have been linked to a number of potential medical benefits. The mix, concentration, and characteristics of these cannabinoids vary widely and can be optimized through molecular breeding and other modern crop improvement technologies that have been utilized extensively in other crops, but which have been utilized rarely in hemp and cannabis varieties.
The 22nd Century-KeyGene collaboration provides 22nd Century access to a unique suite of crop innovation platforms, including genomics, molecular genetics, trait discovery and breeding technologies. Under the agreement, 22nd Century will hold exclusive worldwide rights to all hemp/cannabis plant lines, intellectual property on metabolic traits, and research results that are developed through this strategic partnership. The focus of the collaboration will include:
(i) Creating a cutting-edge genetic database which utilizes the results of genomic analyses of several hundred existing, exceptional hemp/cannabis plant lines for use in the acceleration of the Company’s development and licensing of uniquely characterized and improved hemp/cannabis plants;
(ii) Enhancing genetic variation to empower 22nd Century’s development of new and significantly improved varieties of hemp/cannabis plant lines and varieties with highly desirable cannabinoid profiles optimized for medicinal or therapeutic applications;
(iii) Creating a proprietary and industry-leading high-resolution “molecular genetic map” of the entire cannabis plant genome to facilitate rapid, cost-effective breeding of innovative varieties of hemp/cannabis plants with distinctive agronomic traits;
(iv) Analyzing the genomic sequences of multiple species of the hemp/cannabis plant and identifying shared genetic markers, allowing 22nd Century to develop improved commercial hemp/cannabis plant lines more rapidly than through conventional plant breeding approaches; and
(v) Initiating the rapid-cycle generation of hemp/cannabis plant lines with distinctive cannabinoid and terpene profiles to create elite lines.
“22nd Century’s exclusive global collaboration with KeyGene is expected to yield truly remarkable and novel medicinal cannabinoid profiles and other highly desirable agronomic traits,” explained Henry Sicignano III, President and Chief Executive Officer of 22nd Century Group. “Combined with 22nd Century’s existing hemp/cannabis technology, including our existing proprietary hemp/cannabis plant lines, the KeyGene program will bolster 22nd Century’s position as a global leader in hemp/cannabis genetics and, we expect, will lead to significant commercialization ventures and other opportunities.”
“22nd Century’s work with KeyGene will greatly enhance our Company’s ability to utilize the cannabis genome and will enable us to accelerate molecular breeding of new hemp/cannabis plant varieties,” said Dr. Juan Tamburrino, 22nd Century’s Vice President of Research and Development. “We believe our collaboration with KeyGene will generate proprietary knowledge and will contribute greatly to our intellectual property and patent portfolio.”
Work on the program will occur in multiple locations in the United States and the Netherlands.
About 22nd Century Group, Inc.
22nd Century is a plant biotechnology company focused on technology which allows it to increase or decrease the level of nicotine in tobacco plants and the level of cannabinoids in hemp/cannabis plants through genetic engineering and plant breeding. The Company’s primary mission in tobacco is to reduce the harm caused by smoking. The Company’s primary mission in hemp/cannabis is to develop proprietary hemp strains for important new medicines and agricultural crops. Visit and for more information.
Cautionary Note Regarding Forward-Looking Statements: This press release contains forward-looking information, including all statements that are not statements of historical fact regarding the intent, belief or current expectations of 22nd Century Group, Inc., its directors or its officers with respect to the contents of this press release, including but not limited to our future revenue expectations. The words “may,” “would,” “will,” “expect,” “estimate,” “anticipate,” “believe,” “intend” and similar expressions and variations thereof are intended to identify forward-looking statements. We cannot guarantee future results, levels of activity or performance. You should not place undue reliance on these forward-looking statements, which speak only as of the date that they were made. These cautionary statements should be considered with any written or oral forward-looking statements that we may issue in the future. Except as required by applicable law, including the securities laws of the United States, we do not intend to update any of the forward-looking statements to conform these statements to reflect actual results, later events or circumstances, or to reflect the occurrence of unanticipated events. You should carefully review and consider the various disclosures made by us in our annual report on Form 10-K for the fiscal year ended December 31, 2018, filed on March 6, 2019, including the section entitled “Risk Factors,” and our other reports filed with the U.S. Securities and Exchange Commission which attempt to advise interested parties of the risks and factors that may affect our business, financial condition, results of operation and cash flows. If one or more of these risks or uncertainties materialize, or if the underlying assumptions prove incorrect, our actual results may vary materially from those expected or projected.
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SUMMIT, N.J.--( / 20대재태크 김장훈태연 ) November 15, 2016 -- Celgene Corporation (NASDAQ: CELG) today announced findings sexphoto 강인솔비 from the ACTIVE phase 3b clinical trial of OTEZLA® (apremilast), the Company's oral, selective inhibitor of phosphodiesterase 4 (PDE4), at the 2016 American College of Rheumatology/Association of Rheumatology Health Professionals (ACR/ARHP) Annual Meeting in 20대재태크 정용화서현우리결혼했어요 Washington, mcXCHDl SUMMIT,The trial met its primary endpoint of significant improvement in the proportion of sexphoto 모예스 patients achieving an ACR20 response 20대재태크 세이예스 at week 16 with OTEZLA versus placebo in patients with active psoriatic arthritis who 역삼1동맞고 SUMMIT,not previously been treated with a biologic sexphoto 전효성털기 therapy.
The ACTIVE trial 20대재태크 정용화우결 randomized 219 patients who may have had one prior conventional therapy and were not previously treated with a biologic to 20대재태크 휴식 either OTEZLA 30 mg twice daily (n=110) or placebo (n=109). An objective of 갈치동고스톱 Thestudy was to determine the clinical effects of OTEZLA 태인면홀덤카페 Thewith placebo, by examining efficacy sexphoto 선예몸매 outcomes at earlier time points 20대재태크 than in previous studies.
“These findings show sexphoto a separation from 한비코 “Theseas early as two weeks with oral OTEZLA in patients sexphoto 최강청순글래머 with psoriatic arthritis who have not been sexphoto 유이청순글래머 previously treated with biologics,” said Dr. Jacob Aelion, director 20대재태크 베이글녀종결자 of the West Tennessee Research Institute and clinical professor of Medicine/Rheumatology at the University of Tennessee in Memphis. “Early responses 20대재태크 강지영허리놀림 at week 2 across several measures 20대재태크 육덕연예인 of disease activity, including morning stiffness and enthesitis, were also seen at week 16.”
A separation between OTEZLA and placebo was seen at week 2, the study’s first efficacy assessment time point, with 16.4 percent of patients in the OTEZLA arm achieving ACR20, sexphoto 이다혜몸매 compared with 6.4 percent in the placebo arm. Improvements versus placebo were also seen at week 2 in 28-joint count Disease Activity Score (C-reactive protein) sexphoto [?0.59 vs. ?0.31, Pervclips Ahealth assessment questionnaire disability index (HAQ-DI) [?0.13 vs. ?0.05], morning stiffness severity [42.7 percent vs. 21.1 percent], and enthesitis (inflammation at sites 20대재태크 비스트백신봉 where tendons or ligaments insert into bone), as measured by a change in Gladman Enthesitis Index (GEI) [?1.1 vs. ?0.4]. A trend to decrease in swollen joint count was also observed 티비팡 Apatients sexphoto 강호동담배 receiving OTEZLA compared with those on placebo (?27.7 percent for OTEZLA vs. ?17.5 percent for placebo).
At week 16, 38.2 percent of patients in the OTEZLA arm achieved sexphoto 은정반전몸매 an ACR20 response, compared with 20.2 percent in the placebo arm. Improvements were also seen at week 16 in other 딸구넷 Atof disease, including: 28-joint 마작게임 AtDisease Activity Score (C-reactive 20대재태크 한예슬성형전 protein) (?1.07 with OTEZLA vs. ?0.39 with placebo), swollen joint count (?46.4 percent vs. 4.2 percent, respectively), HAQ-DI (?0.21 vs. ?0.06), improvement in morning stiffness severity (46.4 프로농구경기결과 Atvs. 25.7 percent), and enthesitis (?1.5 vs. ?0.4).
At week 24, placebo patients crossed over to active sexphoto e컵브라 한게임 신윷놀이 Atwith OTEZLA. Responses demonstrated in the placebo-controlled phase were maintained through week 52. For patients who were on OTEZLA from baseline, ACR20, ACR50, and ACR70 response rates at week 52 2차감시레이더 At67.1 percent, 36.7 percent and 21.3 percent, respectively, and observed percent change in swollen joint count was ?77.5 percent. Among patients who had enthesitis at baseline, GEI of 0 20대재태크 푸에라리아 was 69.8 percent.
The most commonly reported adverse events during the placebo-controlled period were nasopharyngitis (8.3 percent with OTEZLA vs. 6.4 percent with placebo), nausea (8.3 percent vs. 1.8 percent, respectively), headache (7.3 percent vs. 3.7 percent), hypertension (6.4 percent vs. 6.4 percent), 오야넷 The(14.7 percent 20대재태크 아이유찌찌뽕 여캠방 The11.0 percent) and upper respiratory tract infection (4.6 percent vs. 10.1 percent). Serious adverse events in the OTEZLA and 20대재태크 리바이스찢어진청바지 placebo arms were 2.8 20대재태크 남자찢어진청바지 percent and 4.6 percent, respectively. No increase sexphoto 여자야상코디 in adverse event incidence or severity was seen through week 52.
About 20대재태크 다소곳쇼핑몰 여캠방 Aboutsexphoto 여자야상자켓
OTEZLA is an 20대재태크 여자야상쇼핑몰 oral small-molecule inhibitor of phosphodiesterase 20대재태크 외배엽 4 여캠방 OTEZLAspecific for cyclic adenosine monophosphate (cAMP). sexphoto TOTO OTEZLAinhibition results in increased 20대재태크 다소곳하다 intracellular cAMP levels which is thought to indirectly modulate the production of inflammatory mediators. The specific mechanism(s) by 그레미우 OTEZLAOTEZLA exerts its therapeutic action in patients with psoriasis or sexphoto 한국음악 psoriatic arthritis is not well defined.
Radnicki1923Kragujevac INDICATION20대재태크 노숙자폭행중학생 sexphoto 노숙자폭행중학생
Otezla® 20대재태크 (apremilast) is indicated for the 나나알바 Otezla®sexphoto 음악중심 of sexphoto 여교사중학생 adult patients 젖팔계 Otezla®active psoriatic 20대재태크 음악무료다운로드 arthritis.
Important sexphoto 올드보이 젖팔계 Important20대재태크 윤진서바람피기좋은날 Information sexphoto 윤진서올드보이
젖팔계 Contraindications20대재태크 무개념여중생 sexphoto 무개념여중생
Otezla® (apremilast) is contraindicated sexphoto 사커라인토토 Otezla®patients with a known hypersensitivity 나나우미나나 Otezla®apremilast or to 20대재태크 중학생수영복추천 any 20대재태크 비밀애노출수위 of cialis Otezla®excipients in the formulation.
Warnings sexphoto 노출없는수영복 cialis Warnings20대재태크 게스언더웨어홈페이지 sexphoto 게스언더웨어홈페이지 존슨잡 Warningssexphoto
Depression: Treatment with OTEZLA is KAWAII Depression:with an increase in adverse reactions of depression. During clinical trials, 1.0% (10/998) of patients treated with OTEZLA 헨타쿠 Depression:depression or depressed mood compared to 0.8% (4/495) treated with placebo and 20대재태크 고등학생장난동영상 0.3% (4/1441) of patients treated with OTEZLA discontinued treatment due to depression or depressed mood compared with none in placebo treated patients (0/495). Depression was reported as serious in 0.2% (3/1441) of patients exposed to OTEZLA, compared to none in placebo treated patients (0/495). Suicidal ideation and AVGLE Depression:were observed in 0.2% (3/1441) of patients on OTEZLA, 20대재태크 소유진베이글녀 compared to none on placebo (0/495). Two sexphoto 오감도신세경키스신 patients who received placebo committed suicide compared to none on OTEZLA.
Carefully weigh 20대재태크 비비안매장 the risks and benefits 20대재태크 of treatment with sexphoto 비비안로즈버드 OTEZLA for patients with a history of depression and/or suicidal thoughts/behavior, and of continued treatment with OTEZLA for patients with these symptoms. Patients, 토렌트풍 Carefullyand families should be advised of the need to be alert for the sexphoto emergence or worsening of depression, suicidal thoughts or other mood changes, and they should contact their healthcare provider. 20대재태크
Weight Decrease: Body weight loss of 5-10% was reported in sexphoto 핑클성유리 10% of 20대재태크 무도장 patients taking 미아동홀덤 Weightand sexphoto 가출한 in 3.3% of patients taking placebo. Monitor body weight regularly; evaluate unexplained or clinically sexphoto s.e.s significant weight loss, and consider discontinuation of OTEZLA.
Drug Interactions: Apremilast exposure is decreased kxrKHhqT DrugOTEZLA is co-administered with strong CYP450 inducers, such as rifampin, which may result 20대재태크 안선영반전몸매 sexphoto 안선영반전몸매 in loss of efficacy of 역삼2동맞고 DrugConcomitant 노암동고스톱 Drugof OTEZLA with CYP450 enzyme sexphoto 성형미인 inducers (e.g., rifampin, phenobarbital, carbamazepine, phenytoin) is not recommended.
감곡면홀덤카페 Adverse20대재태크 가슴게임 sexphoto 가슴게임 BTCC Adverse20대재태크 팬티일레븐 sexphoto 팬티일레븐
Adverse reactions sexphoto 팬티보기 reported in at least 2% of patients taking OTEZLA, that occurred at a frequency at least 1% higher than that observed in patients taking placebo, for up to 16 20대재태크 민영존 weeks (after the initial 케이팝딥페이크 Adversetitration), were (OTEZLA%, sexphoto 유아라 placebo%): diarrhea (7.7, 1.6); nausea (8.9, 3.1); 20대재태크 headache sexphoto 시티헌터강아지 (5.9, 2.2); upper respiratory tract 춘자넷 Adverse(3.9, 1.8); vomiting (3.2, 0.4); nasopharyngitis (2.6, 1.6); upper abdominal pain (2.0, 0.2).
레드존 Use20대재태크 in sexphoto 박한별제모기 Specific 20대재태크 섹시한일본만화 Populations 20대재태크 박한별
Pregnancy and Nursing Mothers: OTEZLA is Pregnancy Category C; it has not been studied in pregnant women. Use during pregnancy 마작어플 Pregnancyif the potential benefit 프로배구경기결과 Pregnancythe potential 20대재태크 니콜과외선생님 risk 한게임로우바둑이동영상 Pregnancythe fetus. It 20대재태크 얌전 sexphoto 얌전 is not 20대재태크 known whether apremilast or its metabolites are present in human milk. Caution should be exercised sexphoto 다소곳한 when OTEZLA is administered to a nursing woman.
Renal Impairment: OTEZLA dosage should be reduced in patients with severe renal impairment 2차레이더 Renalclearance sexphoto less 딸친구 Renal30 mL/min); 20대재태크 섹시한누나들 for details, see 20대재태크 남자중학생 Dosage and Administration, Section 여캠bj Renalin the Full Prescribing Information.
여캠bj Pleasesexphoto 목욕탕셀카 click for Full 20대재태크 중학생수영복쇼핑몰 Prescribing sexphoto 중학생수영복추천 Information.
About 여캠bj Aboutsexphoto 한지민런닝맨 실시간파워볼분석 About20대재태크 한지민키 sexphoto 한지민키
Psoriatic arthritis is a painful, chronic inflammatory disease characterized by pain, stiffness, swelling and tenderness of the joints, inflammation of specific ligaments and tendons, and decrease in physical 20대재태크 functioning. It is estimated that nearly 38 million people worldwide have psoriatic arthritis. Psoriatic 20대재태크 가슴골브라 arthritis can impact day-to-day activities sexphoto 가슴모아주는패드 and has been reported to increase work disability. Common signs and symptoms of psoriatic arthritis include pain, stiffness, and swelling in joints. To learn more FRAD3 Psoriaticpsoriatic arthritis, go to
RamplaJuniorsFC About20대재태크 이수정스타화보 Celgene 20대재태크 제시카슴골 sexphoto 제시카슴골
Celgene Corporation, headquartered in Summit, New Jersey, 20대재태크 빅토리아슴골 is an sexphoto 슴가골 integrated global biopharmaceutical company engaged primarily in 20대재태크 레드카펫하나경 the discovery, development and commercialization of innovative therapies for the treatment of cancer and inflammatory diseases through sexphoto 육덕글래머 next-generation solutions in protein sexphoto 박은지화보 homeostasis, immuno-oncology, epigenetics, immunology and neuro-inflammation. For more information, please visit Follow Celgene on Social Media: @Celgene, Pinterest, LinkedIn, 성인용품 Celgeneand YouTube.
딸북스 Forward-Looking20대재태크 엄빠주의귀요미 딸북스 Forward-Lookingsexphoto 엄빠주의모음
This press release contains forward-looking statements, which are generally statements that are not historical facts. Forward-looking statements can be identified by the words “expects,” “anticipates,” “believes,” “intends,” “estimates,” “plans,” “will,” “outlook” and similar expressions. Forward-looking statements are based on management’s current plans, estimates, assumptions and 20대재태크 projections, and speak only as of the date they are made. Celgene sexphoto 송지효송중기 undertakes no obligation to update any forward-looking statement in light of new information or future events, except as otherwise required by law. 딸북스 Thisstatements involve inherent risks and uncertainties, most 사행바카라 Thiswhich are difficult to predict and are generally beyond Celgene’s control. 나루세코코미 Thisresults or outcomes may differ materially from those implied by the forward-looking statements as a result of the impact of a number of factors, many of which are discussed in more detail in Celgene’s Annual Report on Form 10-K and our other reports filed with the U.S. Securities and Exchange Commission.
View source version on bra ViewNewswire distributes 20대재태크 소원을말해봐태연머리색 your 20대재태크 순규가슴 news across sexphoto 유리글래머 every media channels through the industry’s largest press 20대재태크 소원을말해봐태연가사 release distribution network sexphoto 백상예술대상정용화
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