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BOTHELL, WASH. & CAMBRIDGE, MASS.--( / ) October 29, 2015 -- Seattle Genetics, Inc. () (Nasdaq: SGEN) and Takeda Pharmaceutical Company Limited () (TSE:4502) today announced that the companies have achieved completion of target patient enrollment in the phase 3 ECHELON-1 clinical trial. ECHELON-1 is a randomized trial evaluating ADCETRIS (brentuximab vedotin) as part of a frontline combination chemotherapy regimen in patients with previously untreated advanced classical Hodgkin lymphoma (HL). ADCETRIS is an antibody-drug conjugate (ADC) directed to CD30, a defining marker of classical HL. ADCETRIS is currently not approved for the frontline treatment of HL.

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Patients in ECHELON-1 were randomized to receive either ABVD (Adriamycin, bleomycin, vinblastine, dacarbazine), a recognized standard of care for frontline HL, or a novel combination consisting of ADCETRIS+AVD, which removes bleomycin from the regimen. The trial has enrolled approximately 1,300 patients, although it remains open at select sites to complete enrollment of approximately 20 patients in an additional cohort to fulfill an ex-U.S. regulatory commitment related to measurement of drug levels during treatment (pharmacokinetics). This continued enrollment will not affect the expected timing of data readout from the trial in the 2017 to 2018 timeframe, based on anticipated event rates. The ECHELON-1 trial is being conducted under a Special Protocol Assessment (SPA) agreement from the U.S. Food and Drug Administration (FDA) and the trial also received European Medicines Agency (EMA) scientific advice.

“In the majority of the world, the standard of care for newly diagnosed Hodgkin lymphoma has not changed in more than three decades, and is based on the globally recognized ABVD regimen of four chemotherapy drugs. With the ECHELON-1 clinical trial, our goal is to redefine the standard of care with a novel ADCETRIS-based combination treatment regimen that improves patient outcomes with a manageable safety profile,” said Clay Siegall, Ph.D., President and Chief Executive Officer of Seattle Genetics (). “We look forward to reporting results from the ECHELON-1 trial to potentially support an ADCETRIS supplemental Biologics License Application seeking a label expansion for use in this setting.”

“Approximately 25 percent of newly diagnosed Hodgkin lymphoma patients do not respond to initial therapy or relapse within the first two years. There is a significant need to identify additional potential therapies in this patient population that may provide a more durable response and fewer incidences of relapse,” said Dirk Huebner, MD, Global Clinical Lead, Takeda Oncology.

Data previously presented at the ASH Annual Meeting in 2012 and 2014 from a phase 1 trial evaluating ADCETRIS plus AVD demonstrated that 24 of 25 patients (96 percent) achieved a complete remission. Long-term follow-up data demonstrated three-year overall survival was 100 percent and three-year failure-free survival was 92 percent. The most common adverse events of any grade occurring in more than 30 percent of patients were neutropenia, nausea, peripheral sensory neuropathy, fatigue, vomiting, diarrhea, insomnia, bone pain, constipation and hair loss.

ECHELON-1 Trial design

The randomized, open-label, phase 3 trial is investigating ADCETRIS+AVD versus ABVD as frontline therapy in patients with advanced classical HL. The primary endpoint is modified progression free survival per independent review facility assessment using the Cheson 2007 Revised Response Criteria for Malignant Lymphoma. Secondary endpoints include overall survival, complete remission and safety. The multi-center trial is being conducted in North America, Europe, South America, Australia, Asia and Africa. The study has enrolled approximately 1,300 patients who had histologically-confirmed diagnosis of Stage III or IV classical HL and had not been previously treated with systemic chemotherapy or radiotherapy. Data from the trial will be available when a pre-specified number of PFS events have occurred.

For more information about the trial, please visit

About Classical Hodgkin Lymphoma

Lymphoma is a general term for a group of cancers that originate in the lymphatic system and is the most common type of blood cancer. There are two major categories of lymphoma: HL and non-Hodgkin lymphoma. Classical HL is distinguished from other lymphomas by the characteristic presence of CD30-positive Reed-Sternberg cells.

According to the American Cancer Society, approximately 9,050 cases of HL will be diagnosed in the United States during 2015 and more than 1,150 will die from the disease.

According to the Lymphoma Coalition, over 62,000 people worldwide are diagnosed with HL each year and approximately 25,000 people die each year from this cancer.


ADCETRIS is being evaluated broadly in more than 30 ongoing clinical trials, including the phase 3 ALCANZA trial and two additional phase 3 studies, one in frontline classical HL and one in frontline mature T-cell lymphomas, as well as trials in many additional types of CD30-expressing malignancies, including B-cell lymphomas.

ADCETRIS is an ADC comprising an anti-CD30 monoclonal antibody attached by a protease-cleavable linker to a microtubule disrupting agent, monomethyl auristatin E (MMAE), utilizing Seattle Genetics’ proprietary technology. The ADC employs a linker system that is designed to be stable in the bloodstream but to release MMAE upon internalization into CD30-expressing tumor cells.

ADCETRIS for intravenous injection has received approval from the FDA for three indications: (1) regular approval for the treatment of patients with classical HL after failure of autologous hematopoietic stem cell transplantation (auto-HSCT) or after failure of at least two prior multi-agent chemotherapy regimens in patients who are not auto-HSCT candidates, (2) regular approval for the treatment of classical HL patients at high risk of relapse or progression as post-auto-HSCT consolidation, and (3) accelerated approval for the treatment of patients with systemic anaplastic large cell lymphoma (sALCL) after failure of at least one prior multi-agent chemotherapy regimen. The sALCL indication is approved under accelerated approval based on overall response rate. Continued approval for the sALCL indication may be contingent upon verification and description of clinical benefit in confirmatory trials. Health Canada granted ADCETRIS approval with conditions for relapsed or refractory HL and sALCL.

ADCETRIS was granted conditional marketing authorization by the European Commission in October 2012 for two indications: (1) for the treatment of adult patients with relapsed or refractory CD30-positive HL following autologous stem cell transplant (ASCT), or following at least two prior therapies when ASCT or multi-agent chemotherapy is not a treatment option, and (2) the treatment of adult patients with relapsed or refractory sALCL. ADCETRIS has received marketing authorization by regulatory authorities in more than 55 countries. See important safety information below.

Seattle Genetics and Takeda are jointly developing ADCETRIS. Under the terms of the collaboration agreement, Seattle Genetics has U.S. and Canadian commercialization rights and Takeda has rights to commercialize ADCETRIS in the rest of the world. Seattle Genetics and Takeda are funding joint development costs for ADCETRIS on a 50:50 basis, except in Japan where Takeda is solely responsible for development costs.

About Seattle Genetics

Seattle Genetics is a biotechnology company focused on the development and commercialization of innovative antibody-based therapies for the treatment of cancer. Seattle Genetics is leading the field in developing antibody-drug conjugates (ADCs), a technology designed to harness the targeting ability of antibodies to deliver cell-killing agents directly to cancer cells. The company’s lead product, ADCETRIS® (brentuximab vedotin) is a CD30-targeted ADC that, in collaboration with Takeda Pharmaceutical Company Limited, is commercially available in more than 55 countries, including the U.S., Canada, Japan and members of the European Union. Additionally, ADCETRIS is being evaluated broadly in more than 30 ongoing clinical trials in CD30-expressing malignancies. Seattle Genetics is also advancing a robust pipeline of clinical-stage programs, including SGN-CD19A, SGN-CD33A, SGN-LIV1A, SGN-CD70A, ASG-22ME, ASG-15ME and SEA-CD40. Seattle Genetics has collaborations for its ADC technology with a number of leading biotechnology and pharmaceutical companies, including AbbVie, Agensys (an affiliate of Astellas), Bayer, Genentech, GlaxoSmithKline and Pfizer. More information can be found at

About Takeda

Located in Osaka, Japan, Takeda (TSE: 4502) is a research-based global company with its main focus on pharmaceuticals. As the largest pharmaceutical company in Japan and one of the global leaders of the industry, Takeda is committed to strive towards better health for people worldwide through leading innovation in medicine. Additional information about Takeda is available through its corporate website,

ADCETRIS (brentuximab vedotin) U.S. Important Safety Information


Progressive multifocal leukoencephalopathy (PML): JC virus infection resulting in PML and death can occur in patients receiving ADCETRIS® (brentuximab vedotin).


ADCETRIS is contraindicated with concomitant bleomycin due to pulmonary toxicity (e.g., interstitial infiltration and/or inflammation).

Warnings and Precautions

· Peripheral neuropathy: ADCETRIS treatment causes a peripheral neuropathy that is predominantly sensory. Cases of peripheral motor neuropathy have also been reported. ADCETRIS-induced peripheral neuropathy is cumulative. Monitor patients for symptoms of neuropathy, such as hypoesthesia, hyperesthesia, paresthesia, discomfort, a burning sensation, neuropathic pain or weakness and institute dose modifications accordingly.

· Anaphylaxis and infusion reactions: Infusion-related reactions, including anaphylaxis, have occurred with ADCETRIS. Monitor patients during infusion. If an infusion-related reaction occurs, interrupt the infusion and institute appropriate medical management. If anaphylaxis occurs, immediately and permanently discontinue the infusion and administer appropriate medical therapy.

· Hematologic toxicities: Prolonged (≥1 week) severe neutropenia and Grade 3 or 4 thrombocytopenia or anemia can occur with ADCETRIS. Febrile neutropenia has been reported with ADCETRIS. Monitor complete blood counts prior to each dose of ADCETRIS and consider more frequent monitoring for patients with Grade 3 or 4 neutropenia. Monitor patients for fever. If Grade 3 or 4 neutropenia develops, consider dose delays, reductions, discontinuation, or G-CSF prophylaxis with subsequent doses.

· Serious infections and opportunistic infections: Infections such as pneumonia, bacteremia, and sepsis or septic shock (including fatal outcomes) have been reported in patients treated with ADCETRIS. Closely monitor patients during treatment for the emergence of possible bacterial, fungal or viral infections.

· Tumor lysis syndrome: Closely monitor patients with rapidly proliferating tumor and high tumor burden.

· Increased toxicity in the presence of severe renal impairment: The frequency of ≥Grade 3 adverse reactions and deaths was greater in patients with severe renal impairment compared to patients with normal renal function. Avoid the use of ADCETRIS in patients with severe renal impairment.

· Increased toxicity in the presence of moderate or severe hepatic impairment: The frequency of ≥Grade 3 adverse reactions and deaths was greater in patients with moderate or severe hepatic impairment compared to patients with normal hepatic function. Avoid the use of ADCETRIS in patients with moderate or severe hepatic impairment.

· Hepatotoxicity: Serious cases of hepatotoxicity, including fatal outcomes, have occurred with ADCETRIS. Cases were consistent with hepatocellular injury, including elevations of transaminases and/or bilirubin, and occurred after the first dose of ADCETRIS or rechallenge. Preexisting liver disease, elevated baseline liver enzymes, and concomitant medications may also increase the risk. Monitor liver enzymes and bilirubin. Patients experiencing new, worsening, or recurrent hepatotoxicity may require a delay, change in dose, or discontinuation of ADCETRIS.

· Progressive multifocal leukoencephalopathy (PML): JC virus infection resulting in PML and death has been reported in ADCETRIS-treated patients. First onset of symptoms occurred at various times from initiation of ADCETRIS therapy, with some cases occurring within 3 months of initial exposure. In addition to ADCETRIS therapy, other possible contributory factors include prior therapies and underlying disease that may cause immunosuppression. Consider the diagnosis of PML in any patient presenting with new-onset signs and symptoms of central nervous system abnormalities. Hold ADCETRIS if PML is suspected and discontinue ADCETRIS if PML is confirmed.

· Pulmonary Toxicity: Events of noninfectious pulmonary toxicity including pneumonitis, interstitial lung disease, and acute respiratory distress syndrome, some with fatal outcomes, have been reported. Monitor patients for signs and symptoms of pulmonary toxicity, including cough and dyspnea. In the event of new or worsening pulmonary symptoms, hold ADCETRIS dosing during evaluation and until symptomatic improvement.

· Serious dermatologic reactions: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), including fatal outcomes, have been reported with ADCETRIS. If SJS or TEN occurs, discontinue ADCETRIS and administer appropriate medical therapy.

· Embryo-fetal toxicity: Fetal harm can occur. Advise pregnant women of the potential hazard to the fetus.

Most Common Adverse Reactions:

ADCETRIS was studied as monotherapy in 160 patients with relapsed classical HL and sALCL in two uncontrolled single-arm trials. Across both trials, the most common adverse reactions (≥20%), regardless of causality, were neutropenia, peripheral sensory neuropathy, fatigue, nausea, anemia, upper respiratory tract infection, diarrhea, pyrexia, rash, thrombocytopenia, cough and vomiting.

ADCETRIS was studied in 329 patients with classical HL at high risk of relapse or progression post-auto-HSCT in a placebo-controlled randomized trial. The most common adverse reactions (≥20%) in the ADCETRIS-treatment arm (167 patients), regardless of causality, were neutropenia, peripheral sensory neuropathy, thrombocytopenia, anemia, upper respiratory tract infection, fatigue, peripheral motor neuropathy, nausea, cough, and diarrhea.

Drug Interactions:

Concomitant use of strong CYP3A4 inhibitors or inducers, or P-gp inhibitors, has the potential to affect the exposure to monomethyl auristatin E (MMAE).

Use in Specific Populations:

MMAE exposure and adverse reactions are increased in patients with moderate or severe hepatic impairment or severe renal impairment. Avoid use.

For additional Important Safety Information, including Boxed WARNING, please see the full Prescribing Information for ADCETRIS at

ADCETRIS Global Important Safety Information

ADCETRIS® is indicated for the treatment of adult patients with relapsed or refractory (r/r) CD30+ Hodgkin lymphoma:

1. Following autologous stem cell transplant or

2. Following at least 2 prior therapies when autologous stem cell transplantation is not a treatment option

ADCETRIS is indicated for the treatment of adult patients with relapsed or refractory systemic anaplastic large cell lymphoma (sALCL).

ADCETRIS is contraindicated for patients who are hypersensitive to ADCETRIS. In addition, combined use of bleomycin and ADCETRIS causes pulmonary toxicity, and is contraindicated.

ADCETRIS can cause serious side effects, including:

· Progressive multifocal leukoencephalopathy (PML): John Cunningham virus (JCV) reactivation resulting in PML and death has been reported in patients treated with ADCETRIS. Patients should be closely monitored for new or worsening neurological, cognitive, or behavioral signs or symptoms, which may be suggestive of PML.

· Pancreatitis: Acute pancreatitis has been observed in patients treated with ADCETRIS. Fatal outcomes have been reported. Patients should be closely monitored for new or worsening abdominal pain.

· Pulmonary Toxicity: Cases of pulmonary toxicity have been reported in patients receiving ADCETRIS. In the event of new or worsening pulmonary symptoms (e.g., cough, dyspnoea), a prompt diagnostic evaluation should be performed.

· Serious infections and opportunistic infections: Serious infections such as pneumonia, staphylococcal bacteraemia, sepsis/septic shock (including fatal outcomes), and herpes zoster, and opportunistic infections such as Pneumocystis jiroveci pneumonia and oral candidiasis have been reported in patients treated with ADCETRIS. Patients should be carefully monitored during treatment for emergence of possible serious and opportunistic infections.

· Infusion-related reactions: Immediate and delayed infusion-related reactions, as well as anaphylaxis, have occurred with ADCETRIS. Patients should be carefully monitored during and after an infusion.

· Tumor lysis syndrome (TLS): TLS has been reported with ADCETRIS. Patients with rapidly proliferating tumor and high tumor burden are at risk of TLS and should be monitored closely and managed according to best medical practice.

· Peripheral neuropathy (PN): ADCETRIS treatment may cause PN that is predominantly sensory. Cases of peripheral motor neuropathy have also been reported. Patients should be monitored for symptoms of PN, such as hypoesthesia, hyperesthesia, paresthesia, discomfort, a burning sensation, neuropathic pain, or weakness.

· Hematological toxicities: Grade 3 or Grade 4 anemia, thrombocytopenia, and prolonged (equal to or greater than one week) Grade 3 or Grade 4 neutropenia can occur with ADCETRIS. Complete blood counts should be monitored prior to administration of each dose.

· Febrile neutropenia: Febrile neutropenia has been reported. Patients should be monitored closely for fever and managed according to best medical practice.

· Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN): SJS and TEN have been reported. Fatal outcomes have been reported.

· Hyperglycemia: Hyperglycemia has been reported during trials in patients with an elevated body mass index (BMI) with or without a history of diabetes mellitus. Any patient who experiences an event of hyperglycemia should have their serum glucose closely monitored.

· Renal and hepatic impairment: There is limited experience in patients with renal and hepatic impairment. Population pharmacokinetic analysis indicated that MMAE clearance might be affected by moderate and severe renal impairment, and by low serum albumin concentrations. Elevations in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) have been reported. Liver function should be routinely monitored in patients receiving brentuximab vedotin.

· Sodium content in excipients: This medicinal product contains a maximum of 2.1 mmol (or 47mg) of sodium per dose. To be taken into consideration for patients on a controlled sodium diet.

Serious adverse drug reactions were: neutropenia, thrombocytopenia, constipation, diarrhea, vomiting, pyrexia, peripheral motor neuropathy and peripheral sensory neuropathy, hyperglycemia, demyelinating polyneuropathy, tumor lysis syndrome, and Stevens-Johnson syndrome.

ADCETRIS was studied as monotherapy in 160 patients in two Phase 2 studies. Across both studies, adverse reactions defined as very common (≥1/10) were: infections, neutropenia, peripheral sensory neuropathy, diarrhea, nausea, vomiting, alopecia, pruritis, myalgia, fatigue, pyrexia, and infusion-related reactions. Adverse reactions defined as common (≥1/100 to <1/10) were: upper respiratory tract infection, herpes zoster, pneumonia, anemia, thrombocytopenia, hyperglycemia, peripheral motor neuropathy, dizziness, demyelinating polyneuropathy, cough, dyspnea, constipation, rash, arthralgia, back pain, and chills.

These are not all of the possible side effects with ADCETRIS. Please refer to Summary of Product Characteristics (SmPC) before prescribing.

For Seattle Genetics Forward-Looking Statement:

Certain of the statements made in this press release are forward looking, such as those, among others, relating to the therapeutic and commercial potential of ADCETRIS, including ADCETRIS’ potential as a treatment for advanced classical HL, the anticipated timing of data from the ECHELON-1 trial, the anticipated benefits of Seattle Genetics’ ADCETRIS clinical development program, and the potential submission of a supplemental Biologics License Application seeking a label expansion for ADCETRIS use in the ECHELON-1 setting. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include the risks of adverse events associated with ADCETRIS use, negative or unexpected ADCETRIS clinical trial results even after promising results in earlier company- and investigator-sponsored trials, and adverse regulatory actions affecting ADCETRIS, all of which could result in Seattle Genetics being unable to expand ADCETRIS’ labeled indications of use to the ECHELON-1 or any other settings. Seattle Genetics may also experience delays in the conduct of and obtaining data from the ECHELON-1 and its other clinical trials, in each case for a variety of reasons, including the inherent difficulty and uncertainty of pharmaceutical product development. More information about the risks and uncertainties faced by Seattle Genetics is contained under the caption “Risk Factors” included in Exhibit 99.1 to the company’s Current Report on Form 8-K filed with the Securities and Exchange Commission on September 9, 2015. Seattle Genetics disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

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애프터스쿨소영 해외레이스 중리동출장마사지 경마뉴스 화성떡집 맥금동아로마마사지 광복동토킹bar 123탑 오학동건마 해외채팅사이트 IWC아쿠아타이머 아시아주요증시 붉은고추 헬모스 동대문오피 PornTube막힘 비래동대딸방 애완남키우기나는펫시즌8 양산노래방 북면나이트 아우라제이 성인섹시사진 나라엠앤디주식 선물과옵션 수택동가라오케 VPN/우회접속 토토배트맨 필라델피아유니온 신하동레깅스룸 게임채팅방 롯토 좌동대딸방 프로토배트맨 인터넷카지노추천 화성인가슴I컵 야구리링크 스카이토렌트 야동넷야동 산업분석보고서 복권대박 초대박웃긴동영상 섹스앤더시티사라제시카파커 김유식다빈치코드 일산출장안마│수원출장안마│고양출장안마 현승 활근보한방정력제 오르가즘젤 미국펜팔사이트 과학자 이쁜아이돌 가희글래머 오밤 헤라그라가격 수내동풀싸롱 신관동퍼블릭룸 삼각동토킹bar 박은나노출 샤이니소녀시대움짤 섹시동영상 koreansex 강예진결혼 60년쥐띠 화상채팅만남 86년생남자아이돌 괴곡동성인게임장 로또2등당첨금액 kbs부산뉴스 은정글래머 식만동건마 즉석복권2000 알렉산더왕 황금제비 레인보우지숙남자친구 코리아바카라주소 벳모아 공짜여자알몸사진모음 홀덤게임 우동유흥문화 아동내의싼곳 구룡동키스방 엠마로버츠패션 플라이 왕뽕비키니쇼핑몰 업소아가씨 스마트폰아닌터치폰 여자생식기뾰루지 외음부성형 부산보라카이나이트 타카오카소스케 토토승무패이월 여성알바 케이블받침대 영스탁 파우치형필통 아래 이디야 AVGLE 원더걸스현아사진 전선롤러 메이플스토리레전드캐릭터 연축동성인인형체험 제시카합성사진 EPL예상 역대한국영화흥행순위 모가미카스미 까리제 리빙경마 yamato 전국부업 테크노카지노주소 아이비속옷모델 안전최고 데포르티보칼리 코스닥매매 analdin링크 머니테크 상도동떡집 벨루가카지노주소 아레나수영복세트 배구토토매치 테크노카지노 고잔동노래방 촉촉한걸채팅 안전한포커 프로토승부식 야동동영상보기 김량장동대딸방 손빨넷 모델김소원 sex동영상사이트 김연우이별택시 강원랜드여자 한강수영장수영복 섹슬초고화질 아이유캐릭터 카지노앵벌이 성인기구사이트 태평동노래방 윤지오비키니 도그마 서울개인택시가격 먹튀벅스 베드신 주식예탁증서 비래동리얼돌성인인형 시간전 이해인움짤 조이코믹 sg워너비김용준 놀라운대회스타킹소녀시대 여자클럽패션 무수동리얼돌성인인형 크리스마스아동양말 레인보우a조현영 성기노출방송사고 신세경브라 바른생각콘돔 가희리지 나리타리사 레지던스 송지은아나운서 톱스타a양 씨알-엑스 검은사막 윤두준윤보미 굿인포카 신촌동출장마사지 코리아스코어 MLBPARK 사당1동홀덤바 야동숲 영주동레깅스룸 신민아아맛있다 포토샵cs5움짤 HARDCORESEX 방산동립카페 일본노출게임 중국신인여가수 대성동출장마사지 양서면대딸방 김연우이별택시 퀘레타로FC 대만배우 구멍가게 다대동룸싸롱 주식단기투자 헨타이사이트 3040채팅 노량진1동텍사스홀덤 강남동포커고수 송천동카지노펍 월평동레깅스룸 섹스방송국 방화2동홀덤펍 스타툰 대유신소재주식 훈정동포커고수 미야자키아오이 토토북 장성동홀덤카페 보문동5가성인오락실 선단동안마 쇄운동홀덤룰 연인끼리가면좋은곳 등화동풀싸롱 교복팬티 복정동안마 예지동홀덤룰 에어베드 아몰레드수혜주 삼숭동오마하홀덤 시노자키아이동영상 노숙자폭행중학생 한국섹스 오천면북창pr 걸그룹미모담당 수석동립카페 김연아합사 피버 연금로또당첨금 면목동성인인형체험 장항동안마 탑 전동인싸포커 북가좌2동오마하홀덤 안양시만안구성인오락실 페닐에프린 개봉1동모바일홀덤 성행위 덕과면포커고수 울학교 망원동카지노펍 망원1동텍사스홀덤 박민영장근석 제기동건마 주식잘하기 최고다이순신 장현동카지노펍 스타킹녀 풍남동홀덤룰 누하동카지노펍 청학동홀덤펍 남규리머리색 성인툰 남자친구조루 김재경과거 양현동홀덤룰 은평구방석집 성인영화볼수있는곳 남성용팬티스타킹 섹시각선미 신기면홀덤대회 장윤정노출 장위동모바일홀덤 색스앤더시티시즌6 가정동아로마마사지 보라매동가라오케 PortMelbourneSharks 섹쉬 댄디스타일 화이트생리대 색스폰팅 히트넷 발리풀빌라 예천동출장마사지 이효리키 리지노출 트레비TV 한국영화순위 신동홀덤족보 수신면유흥문화 원당동홀덤바 석남동대딸방 야동다운받는곳 길동유흥 대평동성인인형체험 허가윤성형전후 죽전동북창pr 광복동북창pr 권곡동나이트 PORNHUB 남현동레깅스룸 문래동2가모바일홀덤 부자클럽 진북동카지노펍 사성동룸싸롱 여성부초코송이 괄호체 아이언TV 라이어 장위동홀덤카페 bm98 토판사 팔복동홀덤바 금학동성인게임장 현영동모바일홀덤 진안동홀덤대회 남현동가라오케 군포홀덤바 성인동영상사이트 사조산업 효동북창pr 공평동모바일홀덤 옷벗기기 이승기엄태웅 김아중합성 효민섹시어필 하소동풀싸롱 2013클럽노래 AFCU23축구선수권 기산동레깅스룸 소라접속법 미싱도로시 얼짱몸짱 동완산동카지노펍 전효성키스 아나운서이현주노출 오남동노래방 릴게임알라딘 철산동안마 효린과거사진 문희준i 불가리가방클러치백 교동성인오락실 송천동노래방 초능력종류 봉남면모바일홀덤 조두희 대림동홀덤족보 정자동홀덤룰 구리출장마사지│광주출장마사지│야탑출장마사지 섹시하니 해수욕장성폭행 sexphoto 벗기는동영상 주식투자박살내기 섹시한섹시화보집핫이슈 안드로이드2008 고척동퍼블릭룸 색스코리아성인방송 섹시속옷사진보기 토월드 광주클럽 2011야마토 금강동홀덤룰 문곡동홀덤카페 팔팔정처방 부개동키스방 실시간프로토배팅 서수면홀덤카페 문래동1가모바일홀덤 작은자수 산외면카지노펍 광장동홀덤대회 윤아중국 당산동포커고수 entertainer듣기 미장동홀덤족보 마전동홀덤카페 고딩19금 2011년주식 까르띠에목걸이 중앙동성인오락실 소나기티비 뉴섹스코리아 하이퍼포머 북면레깅스룸 설운동안마 정릉동모바일홀덤 파주퍼블릭룸 아이유가슴성형 해피투게더지연 박얘쁨동영상 동소문동6가홀덤펍 속보 신월동카지노펍 신정동인싸포커 해운대깍두기녀 누드집 광명룸 포토샵3d이미지 케이온유이사진 범양건영주식 키스x키스 산곡동인싸포커 자브DUDE 일본맹렬간호학원 예천동북창pr 아이유허리 여자팬티노출겔러리 안녕하세요박은나 단체섹스 시크릿한선화탈퇴 부산동풀싸롱 성성동출장마사지 스타2인기 로또번호추출프로그램 용강동출장마사지 가평퍼블릭룸 삼선동풀싸롱 연정동홀덤족보 원당동립카페 부곡동대딸방 과천텍사스홀덤 미스에이에이 조금야한이야기 이미지파일보기 바카라 실전머니 리쏘제니스 가수원동안마 청소년관람불가한국영화 중리동모바일홀덤 색스동영상모음 관평동떡집 용지면홀덤대회 박민영소주광고 모델노출화보 견소동오마하홀덤 성내동룸싸롱 람보르기니 수아르 토토온라인 미산동성인오락실 애니다시보기 효자동인싸포커 SG바텐샤이트09 남방동아로마마사지 장기동성인오락실 일산동구홀덤펍 후성목표가 종로caffe 수지키 나운동홀덤대회 구리성인인형체험 철산동홀덤바 축구추천 스포츠중계꼬꼬TV 부대동성인인형체험 종로1가카지노펍 교동성인게임장 KEC주식 과천동홀덤족보 중계2.3동텍사스홀덤 구의2동홀덤족보 당주동홀덤카페 배양동대딸방 화장품가방 sk네트웍스주식 부천다방 미아동리얼돌성인인형 남동성인오락실 ㉿올레벳㉿ 부평홀덤펍 이사동대딸방 마의 성덕동홀덤펍 마나스페이스 당산동4가카지노펍 자놀 사우동아로마마사지 전기차주식 1초후에무서운사진 계동홀덤족보 도원동가라오케 개사동모바일홀덤 천현동유흥주점 레드툰 양서면유흥거리 연천홀덤카페 65g정지선얼굴 창신동텍사스홀덤 덕지천동건마 genetically 연천읍오마하홀덤 교동홀덤바 학장동출장마사지 스포츠내의 연예인비키니화보 자수정목걸이 수청동유흥주점 홍익동건마 즐떡 v걸움짤 공짜19세 노출여대생 이민호담배 단발머리 부곡동성인게임장 현아가슴문신 대정동룸싸롱 상계2동텍사스홀덤 패티쉬 강서구리얼돌성인인형 각선미페티시 송현동홀덤펍 조종면인싸포커 경마문화 겨울수혜주 스마트폰 원지동키스방 대학생만남 둔촌1동모바일홀덤 트리플누드 황연동인싸포커 남자엉덩이살빼는법 스테란 씨스타효린가슴 챨스헤어 팔복동홀덤펍 wolrdsex 주식종목시세 십정동유흥거리 FC샬케04(II) 평원동홀덤펍 문채원성형전후 축구토토배당금 삼청동포커고수 성인망가사이트 관악구유흥주점 아틀레티코파라낸스 데일리룩 창원룸사롱 권곡동대딸방 박효신먼곳에서 박태환수영복 안전한놀이터찾는법 메이플레전드 매탄동방석집 2012학년도대입 장원준군대 카지노에이전시추천 주식통장만드는법 색스모음 프레드니솔론 남방동대딸방 가산동성인용품 롤러코스터tvn 지연노출모음 토토베이 비밀애노출 먹튀신고 PiastGliwice 닥터제프 불륜의시대무삭제 해외선물기초 전보람보아 심곡본동대딸방 심곡동건마 유사 칼리레이젭슨 괴정동노래방 달샤벳비키 삼성카드 먹튀검증업체순위 김연아1위일본반응 센트립구매 마포동유흥문화 한국로맨스영화 인터넷성인영화 슈어맨삽니다 홍도동립카페 노트북으로사진찍기 지연동영상유출 돌체앤가바나남자지갑 여자들의이중언어 내발산동유흥거리 sexkore덩영상 뉴스데스크매형살해 먹튀보상 오천면성인게임장 풍세면떡집 입장면북창pr 70개띠 먹튀업체 밍키넷주소찾기 공짜블랙잭게임 로또무료 g컵탐정호타루토렌트 문산방석집 원당동키스방 에로비디오검색 VfRWormatiaWorms 슈어맨2승부 슈어맨 Sierra 지나산체스beautifulday 과천경마공원 중앙동유흥거리 옥택연군대 주식값 koreasextube 천연여성청결제 Pervclips사이트 FX렌트 성환읍떡집 오금동리얼돌성인인형 부곡동성인게임장 감만동레깅스룸 슈어맨 망우동떡집 김포본좌룸싸롱 씨알리스복용량 씨스타다솜중학교 파생상품투자상담사 주식시세검색 영종도카지노 폴란드엑스트라클라사 주원군대 재밌는한국영화 윤아브라노출 지난주복권 먹튀킬러 포경동영상 먹튀검증커뮤니티 바카라 주이 계수일간 10억만들기프로젝트 복정동토킹bar 자위하는방법 휴바이론주식 이종석담배 강하면립카페 프로축구게임 인간실격 마포동성인게임장 신인여성그룹 빨아주는동영상 슈어맨배너먹튀 박은나 올인원 theentertainer듣기 보라매동나이트 패티쉬 무한도전좀비특집다시보기 양말인형만들기 먹튀쇼미 오늘뉴스속보 속옷노출방송사고 livesexmovies 팔팔정복용방법 석장리동풀싸롱 신세경송중기 고군분투토토사이트 어린이쫄바지 나인뮤지스세라 라빈 범천동레깅스룸 이다해성형전사진 무료야동동영상게임 가오동아로마마사지 제주성인인형체험 콘돔샵 가슴축소수술 어린이채팅 뿔미디어홈페이지 우명동레깅스룸 팬티노출만화 먹튀폴리스심바 1억투자처 초읍동성인게임장 호르몬대체요법 두구동립카페 섹스앤더시티빅 하이킥짧은다리의역습다시보기 대조동유흥거리 강남안마 일본섹시영화 버블팝안무느리게 성북구건마 시크릿노출사진 망월동퍼블릭룸 틴탑엽사 슈어맨시즌3 썬시티카지노주소 모바일복불복게임 감정동건마 핫보지 영동안마 약대동아로마마사지 매화동리얼돌성인인형 휴지킹막힘 보스팅 keyword 대전출신연예인 용문동성인용품 용문동방석집 부사동방석집 슈어맨배너먹튀 요나나스원리 FX학원 오이넷막힘 셀린느티셔츠 사당동안마 천성동토킹bar 신나무비티비 연양동성인인형체험 구하라엉덩이 elw증거금 질성형수술 문배오피 천송동풀싸롱 검상동떡집 YOUR-FREEDOM 네이버카페검색 드라마해피투게더 개금동유흥거리 유이몸무게 19만화 셀린느신발 한국자수 문지동가라오케 이야기채팅 성인사이트접속방법 지금만나러갑니다 박봄육덕 인기연예인 스위트폭스 고추닷컴 성인나라 영성동건마 분리형남자팬티 여성그룹가수 수입비키니샵 섹시팡 전자렌지커버 투니모아 타토 성인무료 로또인터넷구매 피팅모델노출 방배동산후조리원 클리블랜드 별양동키스방 중국노출배우 해외축구 봉곡동성인인형체험 해운대호스트빠 월드컵중계 암사동노래방 내항동리얼돌성인인형 성인영화사이트추천 5월최신 포토샵사진합성하기 pj성인방송 추석특집우리결혼했어요 정선바카라 AV밤 일본야한동영상만화 육봉넷서양야동 왕완비노출사진 폰허브사이트 로또예상번호 하키픽분석 ns윤지성형전 여자라쿤야상 자수정몰 자브서울 SEDABET 3d이미지합치기 19사이즈 누나정액 오늘도달려 영등포본동리얼돌성인인형 11회차야구랭킹 동아에스텍주식 Herediano 여성성기능개선제 잘생긴남자가수 섹스많이나오는영화 임수균 섯다 길음동성인게임장 W툰 섹스밤 구미룸 쫑탬만화 안전한투자 쌍둥이캐릭터 아천동퍼블릭룸 반석동유흥거리 파격노출녀 남자버버리지갑 효평동유흥거리 빅토리아키스앤크라이 신림출장마사지│도봉출장마사지│노원출장마사지 송내동룸싸롱 룸싸롱가이드 성교후두통 musician 배슬기방송사고다시보기 별밤TV 슈퍼더블복권 파타야Utd 싱거미싱 하체경락 별양동키스방 주식하려면 아이에스동서주식 김옥빈숏컷 라니아justgo반복재생 69맥심주소찾기 뮤직스코어 고천동유흥거리 디지털노마드직업 미미123일본야동 복권당첨자 기산동방석집 ELS란 싸이월드동영상링크 펀드수익률순위 강동원한가인호텔 달팽이식당 토토사다리타기 송촌동퍼블릭룸 아프리카댄스녀 30대재무설계 죽성동퍼블릭룸 아이돌스타 키가작은 택연윤아키스 키움증권CMA 아이돌수영선수권대회노출 추천인기릴겜사이트 노래방혼자 조권윤아 가입없는채팅 성북구대딸방 증일동유흥문화 김유미성형외과 야한사이트 북한기쁨조 FC일리치베츠무리우필 에이스갤러퍼 몽블랑남자지갑 슈퍼히어로즈 크리스탈제시카틱톡 경남립카페 오르가슴 가출한 강민경익룡 색스코리아사이트 지연부비부비폰 중화동대딸방 권리세김연아 효학문연구소 누드여자 몽글몽글폰카카오톡 충무동떡집 서대문리얼돌성인인형 피그에이브이 심곡동북창pr 봉정동오피 이승기아이유 김연아영상 원문동리얼돌성인인형 백촌선생 증권개설 네이버모두의마블 카지노사이트 야르시비속옷 일본아나운서 동교동북창pr 섹스이야기 전곡읍레깅스룸 굿찌 추천백경개임 발기력 MLB 위례신도시 채보미화보 스타킹레깅스차이 신사동가로수길카페 여자허리돌리기 카라엉덩이춤동영상 허리돌리는법 뉴화이트 강예빈아프리카 온라인맞고 기산동립카페 하하포커 여자일본연예인 조현영움짤 무한도전좀비특집다시보기 sexy가위바위보 남자초코브라운 명일동오마하홀덤 공릉동성인인형체험 가장섹시한여자 남정동텍사스홀덤 지삿개주상절리 일신동성인인형체험 65g컵현재 김포본좌성인게임장 조촌동텍사스홀덤 현금홀덤사이트 번역사이트추천 꽁머니 가인글래머 길음동풀싸롱 조광피혁주식 원샷홀덤 평촌동리얼돌성인인형 명륜동홀덤카페 중앙동룸싸롱 서정동홀덤펍 야마시타토모히사재중 초미니노출 진안동텍사스홀덤 뉴원더풀게임 첫충 공민지춤 해피케어 성인주민등록번호 대강면텍사스홀덤 sweetbox-addicted 기산동홀덤대회 염리동유흥문화 구하라성신여대 갤러리섹스포토 여의동출장마사지│마포출장마사지│공덕출장마
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