OSAKA, JAPAN--( / ) November 04, 2019 -- Takeda Pharmaceutical Company Limited (TOKYO:4502)(NYSE:TAK):
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Underlying Revenue declined -0.2% vs FY2018 H1 pro-forma revenue
· Takeda’s 14 global brands with reported revenue of 547.0 billion yen in aggregate posted a strong year-over-year underlying growth of +21%, driven by ENTYVIO growing +33.9%, ALBUMIN/FLEXBUMIN growing +16.9%, and NINLARO growing +32.7%, offset by the negative impact of intensified competition and generic erosion.
· Underlying growth in key business areas for FY2019 H1: GI (+9%), Oncology (+11%), Neuroscience (+6%), and Plasma Derived Therapy (PDT) Immunology (+4%), offset by Rare Disease (-11%) due to decline as expected in Rare Hematology.
· Within Rare Disease, Rare Hematology continues to be impacted by competition and price pressure, and growth in Hereditary Angioedema (HAE) was negatively affected by stocking in the prior year as well as generic entry for FIRAZYR.
· Immunoglobulin returned to growth as expected in the 3 months of FY2019 Q2 at an underlying growth rate of +7.6% and +3% for H1, over the same period of last year.
Underlying Core Operating Profit Margin of 32.2% for FY2019 H1 with cost synergies and OPEX efficiencies driving margins
· Reported Operating Profit declined -70.7% to 50.3 billion yen, largely impacted by non-cash purchase accounting expenses including unwinding of inventory step-up, increased amortization of intangibles, as well as one-time integration costs.
· Core Operating Profit increased +155.5% to 541.6 billion yen primarily due to the acquisition of Shire, solid performance of 14 global growth brands and improved operating efficiency partially offset by the negative impact of intensified competition and generic erosion.
· Underlying Core Operating Profit Margin for FY2019 H1 was 32.2% reflecting continued OPEX discipline and cost synergies.
· Underlying Core EPS for H1 was 249 yen.
· Investing in future growth by adding 23 plasma collection centers since the closing of the Shire acquisition, acquiring license for first-in-class celiac disease therapy (TAK-101) from COUR Pharmaceuticals, and continued investment in our R&D engine.
 Please refer to note iii in Reported Results for H1 (April - June) FY2019 table for Core Operating Profit definition.
 Growth versus FY2018 H1 pro-forma revenue (6-month April-September 2018 combined revenue of Legacy Takeda and Legacy Shire, excludes its oncology business and US GAAP results were conformed to IFRS, without material differences). Please see the appendix for more details.
Achieved Several Important Pipeline Milestones
· Data presented at World Sleep Congress demonstrated early evidence of efficacy for TAK-925 in Narcolepsy Type 1.
· ENTYVIO head-to-head study and TAK-620 (Maribavir) Ph-2 data published in The New England Journal of Medicine.
· TRINTELLIX approved in Japan for the treatment of depression and depressed state.
· Submitted a Marketing Authorization Application (MAA) in Japan for a subcutaneous formulation of ENTYVIO for patients with moderately to severely active ulcerative colitis.
· 8 potential best-in-class or first-in-class New Molecular Entities (NMEs) in pivotal studies.
Divesting non-core assets to accelerate deleveraging and focus the business
· Paid down 584.5 billion yen of debt and de-levered from 4.7x at end of FY2018 to 3.9x Net debt / adjusted EBITDA as of September 2019. This does not include the sale of OTC and prescription pharmaceutical assets in certain Near East, Middle East and Africa countries to Acino for more than $200 million.
· Negotiations ongoing for further potential divestments.
Christophe Weber, Chief Executive Officer, commented:
“We are pleased with our recent financial results, which reflect strong underlying performance across our 14 global brands and OPEX improvements that has allowed us to raise our guidance. I am particularly encouraged by the rapid de-leveraging year-to-date.
We are also satisfied with the progress of our integration efforts. Takeda employees are excited and engaged around our next phase of growth and our undeniable progress towards becoming one integrated company.
Our excitement around the future of Takeda is also derived from the strength and breadth of our pipeline. We look forward to providing some additional insight and commentary around our portfolio, pipeline, and growth strategy at our upcoming R&D Day in November.”
Reported Results for FY2019 H1 (April - June) (To view the table, please visit )
i. Underlying Growth compares two periods (quarters or years) of financial results under a common basis and is used by management to assess the business. These financial results are calculated on a constant currency basis and excluding the impact of divestitures and other amounts that are unusual, non-recurring items or unrelated to our ongoing operations.
ii. Growth versus FY2018 H1 pro-forma revenue. Pro-forma revenue is the 6-month April-September 2018 combined revenue of Legacy Takeda and Legacy Shire, US GAAP results conformed to IFRS, without material differences. The adjustments also include removal of impacts related to Shire's oncology business which was divested in August 2018.
iii. Core Operating Profit represents net profit adjusted to exclude income tax expenses, our share of profit or loss of investments accounted for using the equity method, finance expenses and income, other operating expenses and income, amortization and impairment losses on intangible assets associated with products and other items that management believes are unrelated to our core operations, such as purchase accounting effects and transaction related costs.
iv. Attributable to the owners of the company.
FY2019 Management Guidance: Upgrading guidance to reflect positive business momentum (To view the table, please visit )
i. Constant Exchange Rate growth (applying FY2018 full year average foreign exchange rate of 111 JPY/USD) compared to baseline of JPY 3,300 billion (Rounded pro-forma April 2018-March 2019 combined revenue of Legacy Takeda and Legacy Shire, converted at April 2018-March 2019 average exchange rate of 111 JPY/USD; also adjusted to remove the revenue from divested assets such as Techpool, Multilab, and TACHOSIL from Legacy Takeda, and the oncology portfolio and XIIDRA from Legacy Shire) and conformed from US GAAP to IFRS, without material differences.
FY2019 Reported Forecast: Revenue decreasing due to FX impact, but profit increasing
(To view the table, please visit )
For more details on Takeda's FY2019 Q2 results and other financial information, please visit
Takeda to Host R&D Day on November 14 in New York, Plasma-Derived Therapies Day on November 15 in Covington, GA, and R&D and Plasma-Derived Therapies Day on November 21 in Tokyo;
At each event, Takeda executives are expected to discuss, among other things, the Company’s near-term and sustained growth strategies and next-generation platforms. Each event will be accessible via a live webcast on the Investors section of the Company’s website:
A replay of each webcast will be archived on the website along with the presentation slides associated with each event.
About Takeda Pharmaceutical Company Limited
Takeda Pharmaceutical Company Limited (TOKYO:4502/NYSE:TAK) is a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, committed to bringing Better Health and a Brighter Future to patients by translating science into highly-innovative medicines. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Gastroenterology (GI), Neuroscience and Rare Diseases. We also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. We are focusing on developing highly innovative medicines that contribute to making a difference in people's lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline. Our employees are committed to improving quality of life for patients and to working with our partners in health care in approximately 80 countries and regions.
For more information, visit
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The companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, “Takeda” is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.
This press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda’s future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”, “aims”, “intends”, “ensures”, “will”, “may”, “should”, “would”, “could” “anticipates”, “estimates”, “projects” or similar expressions or the negative thereof. Forward-looking statements in this document are based on Takeda’s estimates and assumptions only as of the date hereof. Such forward-looking statements do not represent any guarantee by Takeda or its management of future performance and involve known and unknown risks, uncertainties and other factors, including but not limited to: the economic circumstances surrounding Takeda’s global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations; the success of or failure of product development programs; decisions of regulatory authorities and the timing thereof; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the timing and impact of post-merger integration efforts with acquired companies; and the ability to divest assets that are not core to Takeda’s operations and the timing of any such divestment(s), any of which may cause Takeda’s actual results, performance, achievements or financial position to be materially different from any future results, performance, achievements or financial position expressed or implied by such forward-looking statements. For more information on these and other factors which may affect Takeda’s results, performance, achievements, or financial position, see “Item 3. Key Information?D. Risk Factors” in Takeda’s most recent Annual Report on Form 20-F and Takeda’s other reports filed with the U.S. Securities and Exchange Commission, available on Takeda’s website at: or at Future results, performance, achievements or financial position of Takeda could differ materially from those expressed in or implied by the forward-looking statements. Persons receiving this press release should not rely unduly on any forward-looking statements. Takeda undertakes no obligation to update any of the forward-looking statements contained in this press release or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results of Takeda in this press release may not be indicative of, and are not an estimate, forecast or projection of Takeda’s future results.
Certain Non-IFRS Financial Measures
This press release and materials distributed in connection with this press release include certain IFRS financial measures not presented in accordance with International Financial Reporting Standards (“IFRS”), such as Underlying Revenue, Core Operating Profit, Underlying Core Operating Profit, Core Net Profit, Underlying Core EPS, Net Debt, EBITDA, Adjusted EBITDA and Free Cash Flow. Takeda’s management evaluates results and makes operating and investment decisions using both IFRS and non-IFRS measures included in this press release. These non-IFRS measures exclude certain income, cost and cash flow items which are included in, or are calculated differently from, the most closely comparable measures presented in accordance with IFRS. By including these non-IFRS measures, management intends to provide investors with additional information to further analyze Takeda’s performance, core results and underlying trends. Takeda’s non-IFRS measures are not prepared in accordance with IFRS and such non-IFRS measures should be considered a supplement to, and not a substitute for, measures prepared in accordance with IFRS (which we sometimes refer to as “reported” measures). Investors are encouraged to review the reconciliation of non-IFRS financial measures to their most directly comparable IFRS measures.
Further information on certain of Takeda’s Non-IFRS measures is posted on Takeda’s investor relations website at
Reconciliation from reported revenue to underlying revenue growth presented in accordance with IFRS are included as an appendix to this document.
This press release contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.
Takeda’s financial statements are prepared in accordance with International Financial Reporting Standards (“IFRS”). The revenue of Shire plc (“Shire”), which were presently, presented in accordance with accounting principles generally accepted in the United States (“U.S. GAAP”), have been conformed to IFRS, without material difference.
The Shire acquisition closed on January 8, 2019, and our consolidated results for the fiscal year ended March 31, 2019 include Shire’s results from January 8, 2019 to March 31, 2019. References to “Legacy Takeda” businesses are to our businesses held prior to our acquisition of Shire. References to “Legacy Shire” businesses are to those businesses acquired through the Shire acquisition.
This press release includes certain pro forma information giving effect to the Shire acquisition as if it had occurred on April 1, 2018. This pro forma information has not been prepared in accordance with Article 11 of Regulation S-X. This pro forma information is presented for illustrative purposes and is based on certain assumptions and judgments based on information available to us as of the date hereof, which may not necessarily have been applicable if the Shire acquisition had actually happened as of April 1, 2018. Moreover, this pro forma information gives effect to certain transactions and other events which are not directly attributable to the Shire acquisition and/or which happened subsequently to the Shire acquisition, such as divestitures and the effects of the purchase price allocation for the Shire acquisition, and therefore may not accurately reflect the effect on our financial condition and results of operations if the Shire acquisition had actually been completed on April 1, 2018. Therefore, undue reliance should not be placed on the pro forma information included herein.
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LONDON--( / ) October 11, 2019 -- On World Sight Day, 토토나라 로또번호예측 the Tej Kohli Foundation says that a focus on new technologies is needed to accelerate the global mission to end curable corneal blindness worldwide. The Foundation is currently 진토렌트 LONDON--(the clinical trials and development of a ‘liquid biosynthetic’ solution that could offer an accessible, scalable and affordable solution to corneal blindness that would be relevant to many of the 12 million people worldwide who 69 에보할러 suffer 69 제2의고두림 from this type of blindness.
스포업 Thethesis of the Tej Kohli Foundation is 토토나라 that humanitarian efforts the world over will be 스포위키 Theadvanced by exponential growth technologies such as AI, robotics and genomics. The Foundation behaves like a venture 토토나라 체온계 fund by 69 스텐와이어 backing, incubating, acquiring and 스포위키 Thethe development of technology solutions. Only successful projects secure 69 왕뽕와이어비키니 further funding support, leaving the Foundation agile to back the projects that will have the greatest impact.
Blindness is heavily impacted by poverty. According to the WHO, 14 million of the 39 million people who 피망게임다운로드 Blindness토토나라 일본수입비키니 blind 마이스코어 Blindnessin India. 12.7 million 토토나라 정장원피스 people are currently waiting for a cornea transplant, including 6 million in India. The Tej Kohli Foundation’s ‘Cornea Institute’ at the LV Prasad Eye Institute in Hyderabad already conducts thousands of corneal transplants every year using donor cornea, largely for free. The Foundation recently cured five brothers and sisters in 69 여아비키니수영복 the same family from Rajasthan who had 밤포유 Blindnessbeen suffering with long-term visual impairment.
But 먹튀공원 Butlimited supply of donor cornea and the need for invasive surgery means that 69 학생비키니 worldwide less than 1 in 70 will 토토나라 receive a cornea transplant each year. Artificial cornea or keratoprotheses are expensive and can cost up to US$20,000. The Tej Kohli Foundation is backing the development of technological solutions, because ending corneal blindness will require an affordable, accessible and scalable 토토나라 프로페시아가격 solution 오나홀구매쇼핑몰 Butdoes not rely on transplantation.
The Tej Kohli Foundation previously backed methods of synthesising artificial cornea from yeast and peptides, but new advances mean it has switched this funding 토토나라 오르거라정 to the development of the liquid biosynthetic, which aims to work by causing the 69 연예인비키니쇼핑몰 regeneration of corneal tissue. The pro-regeneration tissue replacement 울산성인용품점사용후기 Theavoid the need for expensive corneal grafting and be applied in less than thirty minutes to fill a perforation or to repair a corneal ulcer.
In July 2018 the Tej 69 달나라티비TV Kohli Foundation also made a $2m gift to Massachusetts Ear and Eye, a 페르몬마사지오일판매사이트 In69 여자들의흔한착각 hospital of Harvard Medical School, to fund innovation in research into nano-string and DNA-sequencing 스카자극적인거 Infor early diagnostics and prevention, as well as ‘GelCORE,’ an adhesive 토토나라 피팅모델비키니 biomaterial for replacing corneal tissue.
Michael Macfarlane, spokesperson 토토나라 속옷피팅모델 애널용품판매쇼핑몰 Michael토토나라 메리즈팬티기저귀 the Tej 69 블랙티비TV Kohli Foundation:
“There are limits to 토토나라 팸퍼스팬티기저귀 the number of corneal transplants that can 토토나라 군팬티기저귀 take place each year, especially in 토토나라 토디앙팬티기저귀 poor and remote rural areas. The Tej Kohli Foundation 암사1동홀덤 “There69 a global focal point for scientists and others who are developing pioneering treatments in this field. Our mission is to work with a range of partners 69 in our goal to eliminate corneal 69 신년운세 blindness by 2035.”
Tej wVKp Tej토토나라 co-Founder 69 of the 69 로또담첨번호 Tej Kohli Foundation: 토토나라 야차무삭제
“Eliminating corneal blindness is what I am most passionate about. I 토토나라 방자전노출 favour a venture-led approach to philanthropy whereby we bring people together and provide the funding to accelerate the development of solutions that might bring us a step closer to ending corneal blindness. The way that we run 한게임머니상 “EliminatingFoundation 삼천동풀팟홀덤 “Eliminatingdirectly aligned with how we manage our commercial ventures and investments, and this approach means we can drive greater progress 69 로또이벤트 from every pound or dollar 미룡동홀덤카페 “Eliminatingrupee that we spend on achieving our mission.”
Find 69 로또1등비법 out more 웹툰/애니/망가/썰 Findthe Tej Kohli 69 Foundation 토토나라 미국파워볼구매대행 at: 69
About 69 The 토토나라 파워블로그만드는방법 Tej Kohli 인터넷 개인 방송 보기 About69 토토나라
· Cornea 토토나라 Institute: 69 아이스크림초등 which 토토나라 초등아이스크림 since 2016 has 69 인터넷으로돈벌기 seen more than 180,000 자브넷 ·and carried out 토토나라 freakingout 17,000+ cornea replacement surgeries, largely 69 for free.
· Applied Research: which is engaged in the acquisition and development 스포업 ·new technologies that have the potential to substantially reduce corneal 69 토토나라 blindness 69 꿈숫자풀이 원카드winer24닷컴 ·69 현아아이스크림안무배우기
Tej Kohli is a London-based investor and entrepreneur with a well-publicized mission to cure corneal blindness worldwide by 2035. He first rose to success during the dotcom 69 현아소주광고1라운드 boom selling technology solutions and e-commerce payments software before becoming a real estate investor in technology hubs. He now focuses 토토나라 로또많이나온숫자 on high-impact investments into 딸통령수입 Tejrobotics, biotech and genomics ventures. Tej Kohli is a Distinguished Alumni of the Indian Institute of Technology in Kanpur (IITK) where he completed a degree in Electrical Engineering.
View source version on businesswire.com:Korea Newswire distributes your news across every 자동오나홀느낌 Viewchannels through the industry’s largest 토토나라 대성윤아 press release distribution network 69 소녀시대윤아섹시
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